Genetic Factors Explain Variation in the Age at Onset of Psoriasis: A Population-based Twin Study

Ann Sophie Lønnberg; Lone Skov; David Lorenzo Duffy; Axel Skytthe; Kirsten Ohm Kyvik; Ole Birger Pedersen; Simon Francis Thomsen

doi:10.2340/00015555-2171

Genetic Factors Explain Variation in the Age at Onset of Psoriasis: A Population-based Twin Study

Ann Sophie Lønnberg, Lone Skov, David Lorenzo Duffy, Axel Skytthe, Kirsten Ohm Kyvik, Ole Birger Pedersen, Simon Francis Thomsen

14 Citations (Scopus)

Abstract

The aim of this study was to determine the age at onset of psoriasis in a population-based twin sample. Questionnaire-data in 10,725 twin pairs, 20-71 years of age, from the Danish Twin Registry, was collected, and analysed using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages was 0.84 (bootstrap standard error?=?0.044) in monozygotic twin pairs and 0.60 (0.051) in dizygotic twin pairs, permutation p?=?0.001. Age at onset of psoriasis in the index twin did not predict risk of psoriasis in the co-twin, hazard ratio (per year of later onset =?1.01 (0.99-1.03), p?=?0.434. In conclusion, these data support that the age at onset of psoriasis is, in part, an inherited property. Our results do not support that early-onset psoriasis is more genetically determined.

Original language	English
Journal	Acta Dermatovenereologica
Volume	96
Issue number	1
Pages (from-to)	35-8
Number of pages	4
ISSN	0001-5555
DOIs	https://doi.org/10.2340/00015555-2171
Publication status	Published - Jan 2016

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title = "Genetic Factors Explain Variation in the Age at Onset of Psoriasis: A Population-based Twin Study",

abstract = "The aim of this study was to determine the age at onset of psoriasis in a population-based twin sample. Questionnaire-data in 10,725 twin pairs, 20-71 years of age, from the Danish Twin Registry, was collected, and analysed using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages was 0.84 (bootstrap standard error?=?0.044) in monozygotic twin pairs and 0.60 (0.051) in dizygotic twin pairs, permutation p?=?0.001. Age at onset of psoriasis in the index twin did not predict risk of psoriasis in the co-twin, hazard ratio (per year of later onset =?1.01 (0.99-1.03), p?=?0.434. In conclusion, these data support that the age at onset of psoriasis is, in part, an inherited property. Our results do not support that early-onset psoriasis is more genetically determined.",

author = "L{\o}nnberg, {Ann Sophie} and Lone Skov and Duffy, {David Lorenzo} and Axel Skytthe and Kyvik, {Kirsten Ohm} and Pedersen, {Ole Birger} and Thomsen, {Simon Francis}",

year = "2016",

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doi = "10.2340/00015555-2171",

language = "English",

volume = "96",

pages = "35--8",

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T1 - Genetic Factors Explain Variation in the Age at Onset of Psoriasis

T2 - A Population-based Twin Study

AU - Lønnberg, Ann Sophie

AU - Skov, Lone

AU - Duffy, David Lorenzo

AU - Skytthe, Axel

AU - Kyvik, Kirsten Ohm

AU - Pedersen, Ole Birger

AU - Thomsen, Simon Francis

PY - 2016/1

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N2 - The aim of this study was to determine the age at onset of psoriasis in a population-based twin sample. Questionnaire-data in 10,725 twin pairs, 20-71 years of age, from the Danish Twin Registry, was collected, and analysed using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages was 0.84 (bootstrap standard error?=?0.044) in monozygotic twin pairs and 0.60 (0.051) in dizygotic twin pairs, permutation p?=?0.001. Age at onset of psoriasis in the index twin did not predict risk of psoriasis in the co-twin, hazard ratio (per year of later onset =?1.01 (0.99-1.03), p?=?0.434. In conclusion, these data support that the age at onset of psoriasis is, in part, an inherited property. Our results do not support that early-onset psoriasis is more genetically determined.

AB - The aim of this study was to determine the age at onset of psoriasis in a population-based twin sample. Questionnaire-data in 10,725 twin pairs, 20-71 years of age, from the Danish Twin Registry, was collected, and analysed using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages was 0.84 (bootstrap standard error?=?0.044) in monozygotic twin pairs and 0.60 (0.051) in dizygotic twin pairs, permutation p?=?0.001. Age at onset of psoriasis in the index twin did not predict risk of psoriasis in the co-twin, hazard ratio (per year of later onset =?1.01 (0.99-1.03), p?=?0.434. In conclusion, these data support that the age at onset of psoriasis is, in part, an inherited property. Our results do not support that early-onset psoriasis is more genetically determined.

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DO - 10.2340/00015555-2171

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JO - Acta Dermatovenereologica

JF - Acta Dermatovenereologica

IS - 1

ER -

Genetic Factors Explain Variation in the Age at Onset of Psoriasis: A Population-based Twin Study

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