Genetic diversity and phylogenetic analysis of the attachment glycoprotein of phocine distemper viruses of the 2002 and 1988 epizootics

Line Nielsen; Peter Arctander; Trine Hammer Jensen; Hans Henrik Dietz; Anne Sofie Hammer; Ashley Banyard; Thomas Barrett; Merete Blixenkrone-Møller

doi:10.1016/j.virusres.2009.04.023

Genetic diversity and phylogenetic analysis of the attachment glycoprotein of phocine distemper viruses of the 2002 and 1988 epizootics

Line Nielsen, Peter Arctander, Trine Hammer Jensen, Hans Henrik Dietz, Anne Sofie Hammer, Ashley Banyard, Thomas Barrett, Merete Blixenkrone-Møller

Functional Genomics

11 Citations (Scopus)

Abstract

To investigate the possible origin and spread of the dramatic re-emergent 2002 distemper epizootic

observed among seals in DanishWaters, we have sequenced wild-type genes of the attachment (H) glycoproteins

of viruses from both the 2002 and 1988 epizootics. Phylogenetic analysis of the H genes of

phocine distemper virus (PDV) together with other morbilliviruses, suggests that the re-emergent 2002

PDV is more closely related to a putative recent ancestral PDV than the 1988 PDV isolates. Moreover,

upsurges of distemper disease in land-living carnivores linked in time and locality to the 2002 seal epizootic

in Danish Waters was investigated and determined to be caused by canine distemper virus, the

closest relative of PDV, revealing no direct epidemiological link to the seal epizootics.

Original language	English
Journal	Virus Research
Volume	144
Issue number	1-2
Pages (from-to)	323-328
Number of pages	6
ISSN	0168-1702
DOIs	https://doi.org/10.1016/j.virusres.2009.04.023
Publication status	Published - 2009

Keywords

Former LIFE faculty

Access to Document

10.1016/j.virusres.2009.04.023

Cite this

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title = "Genetic diversity and phylogenetic analysis of the attachment glycoprotein of phocine distemper viruses of the 2002 and 1988 epizootics",

abstract = "To investigate the possible origin and spread of the dramatic re-emergent 2002 distemper epizooticobserved among seals in DanishWaters, we have sequenced wild-type genes of the attachment (H) glycoproteinsof viruses from both the 2002 and 1988 epizootics. Phylogenetic analysis of the H genes ofphocine distemper virus (PDV) together with other morbilliviruses, suggests that the re-emergent 2002PDV is more closely related to a putative recent ancestral PDV than the 1988 PDV isolates. Moreover,upsurges of distemper disease in land-living carnivores linked in time and locality to the 2002 seal epizooticin Danish Waters was investigated and determined to be caused by canine distemper virus, theclosest relative of PDV, revealing no direct epidemiological link to the seal epizootics.",

keywords = "Former LIFE faculty",

author = "Line Nielsen and Peter Arctander and Jensen, {Trine Hammer} and Dietz, {Hans Henrik} and Hammer, {Anne Sofie} and Ashley Banyard and Thomas Barrett and Merete Blixenkrone-M{\o}ller",

year = "2009",

doi = "10.1016/j.virusres.2009.04.023",

language = "English",

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T1 - Genetic diversity and phylogenetic analysis of the attachment glycoprotein of phocine distemper viruses of the 2002 and 1988 epizootics

AU - Nielsen, Line

AU - Arctander, Peter

AU - Jensen, Trine Hammer

AU - Dietz, Hans Henrik

AU - Hammer, Anne Sofie

AU - Banyard, Ashley

AU - Barrett, Thomas

AU - Blixenkrone-Møller, Merete

PY - 2009

Y1 - 2009

N2 - To investigate the possible origin and spread of the dramatic re-emergent 2002 distemper epizooticobserved among seals in DanishWaters, we have sequenced wild-type genes of the attachment (H) glycoproteinsof viruses from both the 2002 and 1988 epizootics. Phylogenetic analysis of the H genes ofphocine distemper virus (PDV) together with other morbilliviruses, suggests that the re-emergent 2002PDV is more closely related to a putative recent ancestral PDV than the 1988 PDV isolates. Moreover,upsurges of distemper disease in land-living carnivores linked in time and locality to the 2002 seal epizooticin Danish Waters was investigated and determined to be caused by canine distemper virus, theclosest relative of PDV, revealing no direct epidemiological link to the seal epizootics.

AB - To investigate the possible origin and spread of the dramatic re-emergent 2002 distemper epizooticobserved among seals in DanishWaters, we have sequenced wild-type genes of the attachment (H) glycoproteinsof viruses from both the 2002 and 1988 epizootics. Phylogenetic analysis of the H genes ofphocine distemper virus (PDV) together with other morbilliviruses, suggests that the re-emergent 2002PDV is more closely related to a putative recent ancestral PDV than the 1988 PDV isolates. Moreover,upsurges of distemper disease in land-living carnivores linked in time and locality to the 2002 seal epizooticin Danish Waters was investigated and determined to be caused by canine distemper virus, theclosest relative of PDV, revealing no direct epidemiological link to the seal epizootics.

KW - Former LIFE faculty

U2 - 10.1016/j.virusres.2009.04.023

DO - 10.1016/j.virusres.2009.04.023

M3 - Journal article

C2 - 19416744

SN - 0168-1702

VL - 144

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EP - 328

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JF - Virus Research

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