Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Tin Aung; Mineo Ozaki; Mei Chin Lee; Ursula Schlotzer-Schrehardt; Gudmar Thorleifsson; Takanori Mizoguchi; Robert P., Jr. Igo; Aravind Haripriya; Susan E. Williams; Yury S. Astakhov; Andrew C. Orr; Kathryn P. Burdon; Satoko Nakano; Kazuhiko Mori; Khaled Abu-Amero; Michael Hauser; Zheng Li; Gopalakrishnan Prakadeeswari; Jessica N. Cooke Bailey; Alina Popa Cherecheanu; Jae H. Kang; Sarah Nelson; Ken Hayashi; Shin-ichi Manabe; Shigeyasu Kazama; Tomasz Zarnowski; Kenji Inoue; Murat Irkec; Miguel Coca-Prados; Kazuhisa Sugiyama; Irma Jarvela; Patricio Schlottmann; S. Fabian Lerner; Hasnaa Lamari; Yildirim Nilgun; Mukharram Bikbov; Ki Ho Park; Soon Cheol Cha; Kenji Yamashiro; Juan C. Zenteno; Jost B. Jonas; Rajesh S. Kumar; Shamira A. Perera; Anita S. Y. Chan; Nino Kobakhidze; Ronnie George; Lingam Vijaya; Tan Do; Deepak P. Edward; Lourdes de Juan Marcos; Mohammad Pakravan; Sasan Moghimi; Ryuichi Ideta; Daniella Bach-Holm; Per Kappelgaard; Barbara Wirostko; Samuel Thomas; Daniel Gaston; Karen Bedard; Wenda L. Greer; Zhenglin Yang; Xueyi Chen; Lulin Huang; Jinghong Sang; Hongyan Jia; Liyun Jia; Chunyan Qiao; Hui Zhang; Xuyang Liu; Bowen Zhao; Ya-Xing Wang; Liang Xu; Stephanie Leruez; Pascal Reynier; George Chichua; Sergo Tabagari; Steffen Uebe; Matthias Zenkel; Daniel Berner; Georg Mossboeck; Nicole Weisschuh; Ursula Hoja; Ulrich-Christoph Welge-Luessen; Christian Mardin; Panayiota Founti; Anthi Chatzikyriakidou; Theofanis Pappas; Eleftherios Anastasopoulos; Alexandros Lambropoulos; Arkasubhra Ghosh; Rohit Shetty; Natalia Porporato; Vijayan Saravanan; Rengaraj Venkatesh; Chandrashekaran Shivkumar; Narendran Kalpana; Sripriya Sarangapani; Mozhgan R. Kanavi; Afsaneh Naderi Beni; Shahin Yazdani; Alireza Lashay; Homa Naderifar; Nassim Khatibi; Antonio Fea; Carlo Lavia; Laura Dallorto; Teresa Rolle; Paolo Frezzotti; Daniela Paoli; Erika Salvi; Paolo Manunta; Yosai Mori; Kazunori Miyata; Tomomi Higashide; Etsuo Chihara; Satoshi Ishiko; Akitoshi Yoshida; Masahide Yanagi; Yoshiaki Kiuchi; Tsutomu Ohashi; Toshiya Sakurai; Takako Sugimoto; Hideki Chuman; Makoto Aihara; Masaru Inatani; Masahiro Miyake; Norimoto Gotoh; Fumihiko Matsuda; Nagahisa Yoshimura; Yoko Ikeda; Morio Ueno; Chie Sotozono; Jin Wook Jeoung; Min Sagong; Kyu Hyung Park; Jeeyun Ahn; Marisa Cruz-Aguilar; Sidi M. Ezzouhairi; Abderrahman Rafei; Yaan Fun Chong; Xiao Yu Ng; Shuang Ru Goh; Yueming Chen; Victor H. K. Yong; Muhammad Imran Khan; Olusola O. Olawoye; Adeyinka O. Ashaye; Idakwo Ugbede; Adeola Onakoya; Nkiru Kizor-Akaraiwe; Chaiwat Teekhasaenee; Yanin Suwan; Wasu Supakontanasan; Suhanya Okeke; Nkechi J. Uche; Ifeoma Asimadu; Humaira Ayub; Farah Akhtar; Ewa Kosior-Jarecka; Urszula Lukasik; Ignacio Lischinsky; Vania Castro; Rodolfo Perez Grossmann; Gordana Sunaric Megevand; Sylvain Roy; Edward Dervan; Eoin Silke; Aparna Rao; Priti Sahay; Pablo Fornero; Osvaldo Cuello; Delia Sivori; Tamara Zompa; Richard A. Mills; Emmanuelle Souzeau; Paul Mitchell; Jie Jin Wang; Alex W. Hewitt; Michael Coote; Jonathan G. Crowston; Sergei Y. Astakhov; Eugeny L. Akopov; Anton Emelyanov; Vera Vysochinskaya; Gyulli Kazakbaeva; Rinat Fayzrakhmanov; Saleh A. Al-Obeidan; Ohoud Owaidhah; Leyla Ali Aljasim; Balram Chowbay; Jia Nee Foo; Raphael Q. Soh; Kar Seng Sim; Zhicheng Xie; Augustine W. O. Cheong; Shi Qi Mok; Hui Meng Soo; Xiao Yin Chen; Su Qin Peh; Khai Koon Heng; Rahat Husain; Su-Ling Ho; Axel M. Hillmer; Ching-Yu Cheng; Francisco A. Escudero-Dominguez; Rogelio Gonzalez-Sarmiento; Frederico Martinon-Torres; Antonio Salas; Kessara Pathanapitoon; Linda Hansapinyo; Boonsong Wanichwecharugruang; Naris Kitnarong; Anavaj Sakuntabhai; Hip X. Nguyn; Giang T. T. Nguyn; TrNh V. Nguyn; Werner Zenz; Alexander Binder; Daniela S. Klobassa; Martin L. Hibberd; Sonia Davila; Stefan Herms; Markus M. Nothen; Susanne Moebus; Robyn M. Rautenbach; Ari Ziskind; Trevor R. Carmichael; Michele Ramsay; Lydia Alvarez; Montserrat Garcia; Hector Gonzalez-Iglesias; Pedro P. Rodriguez-Calvo; Luis Fernandez-Vega Cueto; Cilingir Oguz; Nevbahar Tamcelik; Eray Atalay; Bilge Batu; Dilek Aktas; Burcu Kasim; M. Roy Wilson; Anne L. Coleman; Yutao Liu; Pratap Challa; Leon Herndon; Rachel W. Kuchtey; John Kuchtey; Karen Curtin; Craig J. Chaya; Alan Crandall; Linda M. Zangwill; Tien Yin Wong; Masakazu Nakano; Shigeru Kinoshita; Anneke I. den Hollander; Eija Vesti; John H. Fingert; Richard K. Lee; Arthur J. Sit; Bradford J. Shingleton; Ningli Wang; Daniele Cusi; Raheel Qamar; Peter Kraft; Margaret A. Pericak-Vance; Soumya Raychaudhuri; Steffen Heegaard; Tero Kivela; Andre Reis; Friedrich E. Kruse; Robert N. Weinreb; Louis R. Pasquale; Jonathan L. Haines; Unnur Thorsteinsdottir; Fridbert Jonasson; R. Rand Allingham; Dan Milea; Robert Ritch; Toshiaki Kubota; Kei Tashiro; Eranga N. Vithana; Shazia Micheal; Fotis Topouzis; Jamie E. Craig; Michael Dubina; Periasamy Sundaresan; Kari Stefansson; Janey L. Wiggs; Francesca Pasutto; Chiea Chuen Khor

doi:10.1038/ng.3875

Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Tin Aung, Mineo Ozaki, Mei Chin Lee, Ursula Schlotzer-Schrehardt, Gudmar Thorleifsson, Takanori Mizoguchi, Robert P., Jr. Igo, Aravind Haripriya, Susan E. Williams, Yury S. Astakhov, Andrew C. Orr, Kathryn P. Burdon, Satoko Nakano, Kazuhiko Mori, Khaled Abu-Amero, Michael Hauser, Zheng Li, Gopalakrishnan Prakadeeswari, Jessica N. Cooke Bailey, Alina Popa CherecheanuJae H. Kang, Sarah Nelson, Ken Hayashi, Shin-ichi Manabe, Shigeyasu Kazama, Tomasz Zarnowski, Kenji Inoue, Murat Irkec, Miguel Coca-Prados, Kazuhisa Sugiyama, Irma Jarvela, Patricio Schlottmann, S. Fabian Lerner, Hasnaa Lamari, Yildirim Nilgun, Mukharram Bikbov, Ki Ho Park, Soon Cheol Cha, Kenji Yamashiro, Juan C. Zenteno, Jost B. Jonas, Rajesh S. Kumar, Shamira A. Perera, Anita S. Y. Chan, Nino Kobakhidze, Ronnie George, Lingam Vijaya, Tan Do, Deepak P. Edward, Lourdes de Juan Marcos, Mohammad Pakravan, Sasan Moghimi, Ryuichi Ideta, Daniella Bach-Holm, Per Kappelgaard, Barbara Wirostko, Samuel Thomas, Daniel Gaston, Karen Bedard, Wenda L. Greer, Zhenglin Yang, Xueyi Chen, Lulin Huang, Jinghong Sang, Hongyan Jia, Liyun Jia, Chunyan Qiao, Hui Zhang, Xuyang Liu, Bowen Zhao, Ya-Xing Wang, Liang Xu, Stephanie Leruez, Pascal Reynier, George Chichua, Sergo Tabagari, Steffen Uebe, Matthias Zenkel, Daniel Berner, Georg Mossboeck, Nicole Weisschuh, Ursula Hoja, Ulrich-Christoph Welge-Luessen, Christian Mardin, Panayiota Founti, Anthi Chatzikyriakidou, Theofanis Pappas, Eleftherios Anastasopoulos, Alexandros Lambropoulos, Arkasubhra Ghosh, Rohit Shetty, Natalia Porporato, Vijayan Saravanan, Rengaraj Venkatesh, Chandrashekaran Shivkumar, Narendran Kalpana, Sripriya Sarangapani, Mozhgan R. Kanavi, Afsaneh Naderi Beni, Shahin Yazdani, Alireza Lashay, Homa Naderifar, Nassim Khatibi, Antonio Fea, Carlo Lavia, Laura Dallorto, Teresa Rolle, Paolo Frezzotti, Daniela Paoli, Erika Salvi, Paolo Manunta, Yosai Mori, Kazunori Miyata, Tomomi Higashide, Etsuo Chihara, Satoshi Ishiko, Akitoshi Yoshida, Masahide Yanagi, Yoshiaki Kiuchi, Tsutomu Ohashi, Toshiya Sakurai, Takako Sugimoto, Hideki Chuman, Makoto Aihara, Masaru Inatani, Masahiro Miyake, Norimoto Gotoh, Fumihiko Matsuda, Nagahisa Yoshimura, Yoko Ikeda, Morio Ueno, Chie Sotozono, Jin Wook Jeoung, Min Sagong, Kyu Hyung Park, Jeeyun Ahn, Marisa Cruz-Aguilar, Sidi M. Ezzouhairi, Abderrahman Rafei, Yaan Fun Chong, Xiao Yu Ng, Shuang Ru Goh, Yueming Chen, Victor H. K. Yong, Muhammad Imran Khan, Olusola O. Olawoye, Adeyinka O. Ashaye, Idakwo Ugbede, Adeola Onakoya, Nkiru Kizor-Akaraiwe, Chaiwat Teekhasaenee, Yanin Suwan, Wasu Supakontanasan, Suhanya Okeke, Nkechi J. Uche, Ifeoma Asimadu, Humaira Ayub, Farah Akhtar, Ewa Kosior-Jarecka, Urszula Lukasik, Ignacio Lischinsky, Vania Castro, Rodolfo Perez Grossmann, Gordana Sunaric Megevand, Sylvain Roy, Edward Dervan, Eoin Silke, Aparna Rao, Priti Sahay, Pablo Fornero, Osvaldo Cuello, Delia Sivori, Tamara Zompa, Richard A. Mills, Emmanuelle Souzeau, Paul Mitchell, Jie Jin Wang, Alex W. Hewitt, Michael Coote, Jonathan G. Crowston, Sergei Y. Astakhov, Eugeny L. Akopov, Anton Emelyanov, Vera Vysochinskaya, Gyulli Kazakbaeva, Rinat Fayzrakhmanov, Saleh A. Al-Obeidan, Ohoud Owaidhah, Leyla Ali Aljasim, Balram Chowbay, Jia Nee Foo, Raphael Q. Soh, Kar Seng Sim, Zhicheng Xie, Augustine W. O. Cheong, Shi Qi Mok, Hui Meng Soo, Xiao Yin Chen, Su Qin Peh, Khai Koon Heng, Rahat Husain, Su-Ling Ho, Axel M. Hillmer, Ching-Yu Cheng, Francisco A. Escudero-Dominguez, Rogelio Gonzalez-Sarmiento, Frederico Martinon-Torres, Antonio Salas, Kessara Pathanapitoon, Linda Hansapinyo, Boonsong Wanichwecharugruang, Naris Kitnarong, Anavaj Sakuntabhai, Hip X. Nguyn, Giang T. T. Nguyn, TrNh V. Nguyn, Werner Zenz, Alexander Binder, Daniela S. Klobassa, Martin L. Hibberd, Sonia Davila, Stefan Herms, Markus M. Nothen, Susanne Moebus, Robyn M. Rautenbach, Ari Ziskind, Trevor R. Carmichael, Michele Ramsay, Lydia Alvarez, Montserrat Garcia, Hector Gonzalez-Iglesias, Pedro P. Rodriguez-Calvo, Luis Fernandez-Vega Cueto, Cilingir Oguz, Nevbahar Tamcelik, Eray Atalay, Bilge Batu, Dilek Aktas, Burcu Kasim, M. Roy Wilson, Anne L. Coleman, Yutao Liu, Pratap Challa, Leon Herndon, Rachel W. Kuchtey, John Kuchtey, Karen Curtin, Craig J. Chaya, Alan Crandall, Linda M. Zangwill, Tien Yin Wong, Masakazu Nakano, Shigeru Kinoshita, Anneke I. den Hollander, Eija Vesti, John H. Fingert, Richard K. Lee, Arthur J. Sit, Bradford J. Shingleton, Ningli Wang, Daniele Cusi, Raheel Qamar, Peter Kraft, Margaret A. Pericak-Vance, Soumya Raychaudhuri, Steffen Heegaard, Tero Kivela, Andre Reis, Friedrich E. Kruse, Robert N. Weinreb, Louis R. Pasquale, Jonathan L. Haines, Unnur Thorsteinsdottir, Fridbert Jonasson, R. Rand Allingham, Dan Milea, Robert Ritch, Toshiaki Kubota, Kei Tashiro, Eranga N. Vithana, Shazia Micheal, Fotis Topouzis, Jamie E. Craig, Michael Dubina, Periasamy Sundaresan, Kari Stefansson, Janey L. Wiggs, Francesca Pasutto, Chiea Chuen Khor

Department of Clinical Medicine

48 Citations (Scopus)

Original language	English
Journal	Nature Genetics
Volume	49
Issue number	7
Pages (from-to)	993–1004
ISSN	1061-4036
DOIs	https://doi.org/10.1038/ng.3875
Publication status	Published - 1 Jul 2017

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Aung, T., Ozaki, M., Lee, M. C., Schlotzer-Schrehardt, U., Thorleifsson, G., Mizoguchi, T., Igo, R. P. . J., Haripriya, A., Williams, S. E., Astakhov, Y. S., Orr, A. C., Burdon, K. P., Nakano, S., Mori, K., Abu-Amero, K., Hauser, M., Li, Z., Prakadeeswari, G., Bailey, J. N. C., ... Khor, C. C. (2017). Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nature Genetics, 49(7), 993–1004. https://doi.org/10.1038/ng.3875

Aung, T, Ozaki, M, Lee, MC, Schlotzer-Schrehardt, U, Thorleifsson, G, Mizoguchi, T, Igo, RPJ, Haripriya, A, Williams, SE, Astakhov, YS, Orr, AC, Burdon, KP, Nakano, S, Mori, K, Abu-Amero, K, Hauser, M, Li, Z, Prakadeeswari, G, Bailey, JNC, Cherecheanu, AP, Kang, JH, Nelson, S, Hayashi, K, Manabe, S, Kazama, S, Zarnowski, T, Inoue, K, Irkec, M, Coca-Prados, M, Sugiyama, K, Jarvela, I, Schlottmann, P, Lerner, SF, Lamari, H, Nilgun, Y, Bikbov, M, Park, KH, Cha, SC, Yamashiro, K, Zenteno, JC, Jonas, JB, Kumar, RS, Perera, SA, Chan, ASY, Kobakhidze, N, George, R, Vijaya, L, Do, T, Edward, DP, de Juan Marcos, L, Pakravan, M, Moghimi, S, Ideta, R, Bach-Holm, D, Kappelgaard, P, Wirostko, B, Thomas, S, Gaston, D, Bedard, K, Greer, WL, Yang, Z, Chen, X, Huang, L, Sang, J, Jia, H, Jia, L, Qiao, C, Zhang, H, Liu, X, Zhao, B, Wang, Y-X, Xu, L, Leruez, S, Reynier, P, Chichua, G, Tabagari, S, Uebe, S, Zenkel, M, Berner, D, Mossboeck, G, Weisschuh, N, Hoja, U, Welge-Luessen, U-C, Mardin, C, Founti, P, Chatzikyriakidou, A, Pappas, T, Anastasopoulos, E, Lambropoulos, A, Ghosh, A, Shetty, R, Porporato, N, Saravanan, V, Venkatesh, R, Shivkumar, C, Kalpana, N, Sarangapani, S, Kanavi, MR, Beni, AN, Yazdani, S, Lashay, A, Naderifar, H, Khatibi, N, Fea, A, Lavia, C, Dallorto, L, Rolle, T, Frezzotti, P, Paoli, D, Salvi, E, Manunta, P, Mori, Y, Miyata, K, Higashide, T, Chihara, E, Ishiko, S, Yoshida, A, Yanagi, M, Kiuchi, Y, Ohashi, T, Sakurai, T, Sugimoto, T, Chuman, H, Aihara, M, Inatani, M, Miyake, M, Gotoh, N, Matsuda, F, Yoshimura, N, Ikeda, Y, Ueno, M, Sotozono, C, Jeoung, JW, Sagong, M, Park, KH, Ahn, J, Cruz-Aguilar, M, Ezzouhairi, SM, Rafei, A, Chong, YF, Ng, XY, Goh, SR, Chen, Y, Yong, VHK, Khan, MI, Olawoye, OO, Ashaye, AO, Ugbede, I, Onakoya, A, Kizor-Akaraiwe, N, Teekhasaenee, C, Suwan, Y, Supakontanasan, W, Okeke, S, Uche, NJ, Asimadu, I, Ayub, H, Akhtar, F, Kosior-Jarecka, E, Lukasik, U, Lischinsky, I, Castro, V, Perez Grossmann, R, Megevand, GS, Roy, S, Dervan, E, Silke, E, Rao, A, Sahay, P, Fornero, P, Cuello, O, Sivori, D, Zompa, T, Mills, RA, Souzeau, E, Mitchell, P, Wang, JJ, Hewitt, AW, Coote, M, Crowston, JG, Astakhov, SY, Akopov, EL, Emelyanov, A, Vysochinskaya, V, Kazakbaeva, G, Fayzrakhmanov, R, Al-Obeidan, SA, Owaidhah, O, Aljasim, LA, Chowbay, B, Foo, JN, Soh, RQ, Sim, KS, Xie, Z, Cheong, AWO, Mok, SQ, Soo, HM, Chen, XY, Peh, SQ, Heng, KK, Husain, R, Ho, S-L, Hillmer, AM, Cheng, C-Y, Escudero-Dominguez, FA, Gonzalez-Sarmiento, R, Martinon-Torres, F, Salas, A, Pathanapitoon, K, Hansapinyo, L, Wanichwecharugruang, B, Kitnarong, N, Sakuntabhai, A, Nguyn, HX, Nguyn, GTT, Nguyn, TV, Zenz, W, Binder, A, Klobassa, DS, Hibberd, ML, Davila, S, Herms, S, Nothen, MM, Moebus, S, Rautenbach, RM, Ziskind, A, Carmichael, TR, Ramsay, M, Alvarez, L, Garcia, M, Gonzalez-Iglesias, H, Rodriguez-Calvo, PP, Fernandez-Vega Cueto, L, Oguz, C, Tamcelik, N, Atalay, E, Batu, B, Aktas, D, Kasim, B, Wilson, MR, Coleman, AL, Liu, Y, Challa, P, Herndon, L, Kuchtey, RW, Kuchtey, J, Curtin, K, Chaya, CJ, Crandall, A, Zangwill, LM, Wong, TY, Nakano, M, Kinoshita, S, den Hollander, AI, Vesti, E, Fingert, JH, Lee, RK, Sit, AJ, Shingleton, BJ, Wang, N, Cusi, D, Qamar, R, Kraft, P, Pericak-Vance, MA, Raychaudhuri, S, Heegaard, S, Kivela, T, Reis, A, Kruse, FE, Weinreb, RN, Pasquale, LR, Haines, JL, Thorsteinsdottir, U, Jonasson, F, Allingham, RR, Milea, D, Ritch, R, Kubota, T, Tashiro, K, Vithana, EN, Micheal, S, Topouzis, F, Craig, JE, Dubina, M, Sundaresan, P, Stefansson, K, Wiggs, JL, Pasutto, F & Khor, CC 2017, 'Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci', Nature Genetics, vol. 49, no. 7, pp. 993–1004. https://doi.org/10.1038/ng.3875

@article{d58cefca10a944c180768104aa3a597c,

title = "Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci",

author = "Tin Aung and Mineo Ozaki and Lee, {Mei Chin} and Ursula Schlotzer-Schrehardt and Gudmar Thorleifsson and Takanori Mizoguchi and Igo, {Robert P., Jr.} and Aravind Haripriya and Williams, {Susan E.} and Astakhov, {Yury S.} and Orr, {Andrew C.} and Burdon, {Kathryn P.} and Satoko Nakano and Kazuhiko Mori and Khaled Abu-Amero and Michael Hauser and Zheng Li and Gopalakrishnan Prakadeeswari and Bailey, {Jessica N. Cooke} and Cherecheanu, {Alina Popa} and Kang, {Jae H.} and Sarah Nelson and Ken Hayashi and Shin-ichi Manabe and Shigeyasu Kazama and Tomasz Zarnowski and Kenji Inoue and Murat Irkec and Miguel Coca-Prados and Kazuhisa Sugiyama and Irma Jarvela and Patricio Schlottmann and Lerner, {S. Fabian} and Hasnaa Lamari and Yildirim Nilgun and Mukharram Bikbov and Park, {Ki Ho} and Cha, {Soon Cheol} and Kenji Yamashiro and Zenteno, {Juan C.} and Jonas, {Jost B.} and Kumar, {Rajesh S.} and Perera, {Shamira A.} and Chan, {Anita S. Y.} and Nino Kobakhidze and Ronnie George and Lingam Vijaya and Tan Do and Edward, {Deepak P.} and {de Juan Marcos}, Lourdes and Mohammad Pakravan and Sasan Moghimi and Ryuichi Ideta and Daniella Bach-Holm and Per Kappelgaard and Barbara Wirostko and Samuel Thomas and Daniel Gaston and Karen Bedard and Greer, {Wenda L.} and Zhenglin Yang and Xueyi Chen and Lulin Huang and Jinghong Sang and Hongyan Jia and Liyun Jia and Chunyan Qiao and Hui Zhang and Xuyang Liu and Bowen Zhao and Ya-Xing Wang and Liang Xu and Stephanie Leruez and Pascal Reynier and George Chichua and Sergo Tabagari and Steffen Uebe and Matthias Zenkel and Daniel Berner and Georg Mossboeck and Nicole Weisschuh and Ursula Hoja and Ulrich-Christoph Welge-Luessen and Christian Mardin and Panayiota Founti and Anthi Chatzikyriakidou and Theofanis Pappas and Eleftherios Anastasopoulos and Alexandros Lambropoulos and Arkasubhra Ghosh and Rohit Shetty and Natalia Porporato and Vijayan Saravanan and Rengaraj Venkatesh and Chandrashekaran Shivkumar and Narendran Kalpana and Sripriya Sarangapani and Kanavi, {Mozhgan R.} and Beni, {Afsaneh Naderi} and Shahin Yazdani and Alireza Lashay and Homa Naderifar and Nassim Khatibi and Antonio Fea and Carlo Lavia and Laura Dallorto and Teresa Rolle and Paolo Frezzotti and Daniela Paoli and Erika Salvi and Paolo Manunta and Yosai Mori and Kazunori Miyata and Tomomi Higashide and Etsuo Chihara and Satoshi Ishiko and Akitoshi Yoshida and Masahide Yanagi and Yoshiaki Kiuchi and Tsutomu Ohashi and Toshiya Sakurai and Takako Sugimoto and Hideki Chuman and Makoto Aihara and Masaru Inatani and Masahiro Miyake and Norimoto Gotoh and Fumihiko Matsuda and Nagahisa Yoshimura and Yoko Ikeda and Morio Ueno and Chie Sotozono and Jeoung, {Jin Wook} and Min Sagong and Park, {Kyu Hyung} and Jeeyun Ahn and Marisa Cruz-Aguilar and Ezzouhairi, {Sidi M.} and Abderrahman Rafei and Chong, {Yaan Fun} and Ng, {Xiao Yu} and Goh, {Shuang Ru} and Yueming Chen and Yong, {Victor H. K.} and Khan, {Muhammad Imran} and Olawoye, {Olusola O.} and Ashaye, {Adeyinka O.} and Idakwo Ugbede and Adeola Onakoya and Nkiru Kizor-Akaraiwe and Chaiwat Teekhasaenee and Yanin Suwan and Wasu Supakontanasan and Suhanya Okeke and Uche, {Nkechi J.} and Ifeoma Asimadu and Humaira Ayub and Farah Akhtar and Ewa Kosior-Jarecka and Urszula Lukasik and Ignacio Lischinsky and Vania Castro and {Perez Grossmann}, Rodolfo and Megevand, {Gordana Sunaric} and Sylvain Roy and Edward Dervan and Eoin Silke and Aparna Rao and Priti Sahay and Pablo Fornero and Osvaldo Cuello and Delia Sivori and Tamara Zompa and Mills, {Richard A.} and Emmanuelle Souzeau and Paul Mitchell and Wang, {Jie Jin} and Hewitt, {Alex W.} and Michael Coote and Crowston, {Jonathan G.} and Astakhov, {Sergei Y.} and Akopov, {Eugeny L.} and Anton Emelyanov and Vera Vysochinskaya and Gyulli Kazakbaeva and Rinat Fayzrakhmanov and Al-Obeidan, {Saleh A.} and Ohoud Owaidhah and Aljasim, {Leyla Ali} and Balram Chowbay and Foo, {Jia Nee} and Soh, {Raphael Q.} and Sim, {Kar Seng} and Zhicheng Xie and Cheong, {Augustine W. O.} and Mok, {Shi Qi} and Soo, {Hui Meng} and Chen, {Xiao Yin} and Peh, {Su Qin} and Heng, {Khai Koon} and Rahat Husain and Su-Ling Ho and Hillmer, {Axel M.} and Ching-Yu Cheng and Escudero-Dominguez, {Francisco A.} and Rogelio Gonzalez-Sarmiento and Frederico Martinon-Torres and Antonio Salas and Kessara Pathanapitoon and Linda Hansapinyo and Boonsong Wanichwecharugruang and Naris Kitnarong and Anavaj Sakuntabhai and Nguyn, {Hip X.} and Nguyn, {Giang T. T.} and Nguyn, {TrNh V.} and Werner Zenz and Alexander Binder and Klobassa, {Daniela S.} and Hibberd, {Martin L.} and Sonia Davila and Stefan Herms and Nothen, {Markus M.} and Susanne Moebus and Rautenbach, {Robyn M.} and Ari Ziskind and Carmichael, {Trevor R.} and Michele Ramsay and Lydia Alvarez and Montserrat Garcia and Hector Gonzalez-Iglesias and Rodriguez-Calvo, {Pedro P.} and {Fernandez-Vega Cueto}, Luis and Cilingir Oguz and Nevbahar Tamcelik and Eray Atalay and Bilge Batu and Dilek Aktas and Burcu Kasim and Wilson, {M. Roy} and Coleman, {Anne L.} and Yutao Liu and Pratap Challa and Leon Herndon and Kuchtey, {Rachel W.} and John Kuchtey and Karen Curtin and Chaya, {Craig J.} and Alan Crandall and Zangwill, {Linda M.} and Wong, {Tien Yin} and Masakazu Nakano and Shigeru Kinoshita and {den Hollander}, {Anneke I.} and Eija Vesti and Fingert, {John H.} and Lee, {Richard K.} and Sit, {Arthur J.} and Shingleton, {Bradford J.} and Ningli Wang and Daniele Cusi and Raheel Qamar and Peter Kraft and Pericak-Vance, {Margaret A.} and Soumya Raychaudhuri and Steffen Heegaard and Tero Kivela and Andre Reis and Kruse, {Friedrich E.} and Weinreb, {Robert N.} and Pasquale, {Louis R.} and Haines, {Jonathan L.} and Unnur Thorsteinsdottir and Fridbert Jonasson and Allingham, {R. Rand} and Dan Milea and Robert Ritch and Toshiaki Kubota and Kei Tashiro and Vithana, {Eranga N.} and Shazia Micheal and Fotis Topouzis and Craig, {Jamie E.} and Michael Dubina and Periasamy Sundaresan and Kari Stefansson and Wiggs, {Janey L.} and Francesca Pasutto and Khor, {Chiea Chuen}",

year = "2017",

month = jul,

day = "1",

doi = "10.1038/ng.3875",

language = "English",

volume = "49",

pages = "993–1004",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "nature publishing group",

number = "7",

}

TY - JOUR

T1 - Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

AU - Aung, Tin

AU - Ozaki, Mineo

AU - Lee, Mei Chin

AU - Schlotzer-Schrehardt, Ursula

AU - Thorleifsson, Gudmar

AU - Mizoguchi, Takanori

AU - Igo, Robert P., Jr.

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PY - 2017/7/1

Y1 - 2017/7/1

U2 - 10.1038/ng.3875

DO - 10.1038/ng.3875

M3 - Journal article

C2 - 28553957

SN - 1061-4036

VL - 49

SP - 993

EP - 1004

JO - Nature Genetics

JF - Nature Genetics

IS - 7

ER -

Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

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