Gene expression of the endolymphatic sac

Morten Friis; Tomas Martin-Bertelsen; Lennart Friis-Hansen; Ole Winther; Ricardo Henao Giraldo; Mads Sølvsten Sørensen; Klaus Qvortrup

doi:10.3109/00016489.2011.616910

Gene expression of the endolymphatic sac

Morten Friis, Tomas Martin-Bertelsen, Lennart Friis-Hansen, Ole Winther, Ricardo Henao Giraldo, Mads Sølvsten Sørensen, Klaus Qvortrup

15 Citations (Scopus)

Abstract

Conclusion: The endolymphatic sac is part of the membranous inner ear and is thought to play a role in the fluid homeostasis and immune defense of the inner ear; however, the exact function of the endolymphatic sac is not fully known. Many of the detected mRNAs in this study suggest that the endolymphatic sac has multiple and diverse functions in the inner ear. Objectives:The objective of this study was to provide a comprehensive review of the genes expressed in the endolymphatic sac in the rat and perform a functional characterization based on measured mRNA abundance. Methods:Microarray technology was used to investigate the gene expression of the endolymphatic sac with the surrounding dura. Characteristic and novel endolymphatic sac genes were determined by comparing with expressions in pure dura. Results: In all, 463 genes were identified specific for the endolymphatic sac. Functional annotation clustering revealed 29 functional clusters.

Original language	English
Journal	Acta Oto-Laryngologica
Volume	131
Issue number	12
Pages (from-to)	1257-63
Number of pages	7
ISSN	0001-6489
DOIs	https://doi.org/10.3109/00016489.2011.616910
Publication status	Published - Dec 2011

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title = "Gene expression of the endolymphatic sac",

abstract = "Conclusion: The endolymphatic sac is part of the membranous inner ear and is thought to play a role in the fluid homeostasis and immune defense of the inner ear; however, the exact function of the endolymphatic sac is not fully known. Many of the detected mRNAs in this study suggest that the endolymphatic sac has multiple and diverse functions in the inner ear. Objectives:The objective of this study was to provide a comprehensive review of the genes expressed in the endolymphatic sac in the rat and perform a functional characterization based on measured mRNA abundance. Methods:Microarray technology was used to investigate the gene expression of the endolymphatic sac with the surrounding dura. Characteristic and novel endolymphatic sac genes were determined by comparing with expressions in pure dura. Results: In all, 463 genes were identified specific for the endolymphatic sac. Functional annotation clustering revealed 29 functional clusters.",

author = "Morten Friis and Tomas Martin-Bertelsen and Lennart Friis-Hansen and Ole Winther and {Henao Giraldo}, Ricardo and S{\o}rensen, {Mads S{\o}lvsten} and Klaus Qvortrup",

year = "2011",

month = dec,

doi = "10.3109/00016489.2011.616910",

language = "English",

volume = "131",

pages = "1257--63",

journal = "Acta Oto-Laryngologica",

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TY - JOUR

T1 - Gene expression of the endolymphatic sac

AU - Friis, Morten

AU - Martin-Bertelsen, Tomas

AU - Friis-Hansen, Lennart

AU - Winther, Ole

AU - Henao Giraldo, Ricardo

AU - Sørensen, Mads Sølvsten

AU - Qvortrup, Klaus

PY - 2011/12

Y1 - 2011/12

N2 - Conclusion: The endolymphatic sac is part of the membranous inner ear and is thought to play a role in the fluid homeostasis and immune defense of the inner ear; however, the exact function of the endolymphatic sac is not fully known. Many of the detected mRNAs in this study suggest that the endolymphatic sac has multiple and diverse functions in the inner ear. Objectives:The objective of this study was to provide a comprehensive review of the genes expressed in the endolymphatic sac in the rat and perform a functional characterization based on measured mRNA abundance. Methods:Microarray technology was used to investigate the gene expression of the endolymphatic sac with the surrounding dura. Characteristic and novel endolymphatic sac genes were determined by comparing with expressions in pure dura. Results: In all, 463 genes were identified specific for the endolymphatic sac. Functional annotation clustering revealed 29 functional clusters.

AB - Conclusion: The endolymphatic sac is part of the membranous inner ear and is thought to play a role in the fluid homeostasis and immune defense of the inner ear; however, the exact function of the endolymphatic sac is not fully known. Many of the detected mRNAs in this study suggest that the endolymphatic sac has multiple and diverse functions in the inner ear. Objectives:The objective of this study was to provide a comprehensive review of the genes expressed in the endolymphatic sac in the rat and perform a functional characterization based on measured mRNA abundance. Methods:Microarray technology was used to investigate the gene expression of the endolymphatic sac with the surrounding dura. Characteristic and novel endolymphatic sac genes were determined by comparing with expressions in pure dura. Results: In all, 463 genes were identified specific for the endolymphatic sac. Functional annotation clustering revealed 29 functional clusters.

U2 - 10.3109/00016489.2011.616910

DO - 10.3109/00016489.2011.616910

M3 - Journal article

C2 - 22017353

SN - 0001-6489

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SP - 1257

EP - 1263

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

IS - 12

ER -

Gene expression of the endolymphatic sac

Abstract

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