Gene expression of LOX-1, VCAM-1, and ICAM-1 in pre-atherosclerotic mice.

Anne Mette Fisker Hag; Sune Folke Pedersen; Andreas Kjaer

doi:10.1016/j.bbrc.2008.10.037

Gene expression of LOX-1, VCAM-1, and ICAM-1 in pre-atherosclerotic mice.

Anne Mette Fisker Hag, Sune Folke Pedersen, Andreas Kjaer

20 Citations (Scopus)

Abstract

To identify markers of the earliest stage of atherosclerosis, endothelial dysfunction, we evaluated the gene expression of lectin-like oxidized-low-density-lipoprotein receptor-1 (LOX-1), vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) in very young pre-atherosclerotic mice. Furthermore, the plasma levels of the soluble VCAM-1 and ICAM-1 were compared to the gene expression profiles. Gene expressions of LOX-1 and VCAM-1 were up-regulated in young apoE(-/-) mice, and thus, it seems probable that these genes play a role in pre-atherosclerosis. Contrarily, the gene expression profile of ICAM-1 did not show any apparent differences between the groups, questioning the involvement of this molecule in the early development of atherosclerosis. Plasma levels of sVCAM-1 and sICAM-1 were similar in all mice and did not correlate with the vascular gene expression of the corresponding genes. It therefore seems likely that these circulating markers are not suited to detect early atherosclerosis.

Original language	English
Journal	Biochemical and Biophysical Research Communications
Volume	377/2
Pages (from-to)	689-693
Number of pages	5
ISSN	0006-291X
DOIs	https://doi.org/10.1016/j.bbrc.2008.10.037
Publication status	Published - 2008

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title = "Gene expression of LOX-1, VCAM-1, and ICAM-1 in pre-atherosclerotic mice.",

abstract = "To identify markers of the earliest stage of atherosclerosis, endothelial dysfunction, we evaluated the gene expression of lectin-like oxidized-low-density-lipoprotein receptor-1 (LOX-1), vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) in very young pre-atherosclerotic mice. Furthermore, the plasma levels of the soluble VCAM-1 and ICAM-1 were compared to the gene expression profiles. Gene expressions of LOX-1 and VCAM-1 were up-regulated in young apoE(-/-) mice, and thus, it seems probable that these genes play a role in pre-atherosclerosis. Contrarily, the gene expression profile of ICAM-1 did not show any apparent differences between the groups, questioning the involvement of this molecule in the early development of atherosclerosis. Plasma levels of sVCAM-1 and sICAM-1 were similar in all mice and did not correlate with the vascular gene expression of the corresponding genes. It therefore seems likely that these circulating markers are not suited to detect early atherosclerosis.",

author = "{Fisker Hag}, {Anne Mette} and Pedersen, {Sune Folke} and Andreas Kjaer",

note = "Paper id:: 18930708",

year = "2008",

doi = "10.1016/j.bbrc.2008.10.037",

language = "English",

volume = "377/2",

pages = "689--693",

journal = "Biochemical and Biophysical Research Communications",

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TY - JOUR

T1 - Gene expression of LOX-1, VCAM-1, and ICAM-1 in pre-atherosclerotic mice.

AU - Fisker Hag, Anne Mette

AU - Pedersen, Sune Folke

AU - Kjaer, Andreas

N1 - Paper id:: 18930708

PY - 2008

Y1 - 2008

N2 - To identify markers of the earliest stage of atherosclerosis, endothelial dysfunction, we evaluated the gene expression of lectin-like oxidized-low-density-lipoprotein receptor-1 (LOX-1), vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) in very young pre-atherosclerotic mice. Furthermore, the plasma levels of the soluble VCAM-1 and ICAM-1 were compared to the gene expression profiles. Gene expressions of LOX-1 and VCAM-1 were up-regulated in young apoE(-/-) mice, and thus, it seems probable that these genes play a role in pre-atherosclerosis. Contrarily, the gene expression profile of ICAM-1 did not show any apparent differences between the groups, questioning the involvement of this molecule in the early development of atherosclerosis. Plasma levels of sVCAM-1 and sICAM-1 were similar in all mice and did not correlate with the vascular gene expression of the corresponding genes. It therefore seems likely that these circulating markers are not suited to detect early atherosclerosis.

AB - To identify markers of the earliest stage of atherosclerosis, endothelial dysfunction, we evaluated the gene expression of lectin-like oxidized-low-density-lipoprotein receptor-1 (LOX-1), vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) in very young pre-atherosclerotic mice. Furthermore, the plasma levels of the soluble VCAM-1 and ICAM-1 were compared to the gene expression profiles. Gene expressions of LOX-1 and VCAM-1 were up-regulated in young apoE(-/-) mice, and thus, it seems probable that these genes play a role in pre-atherosclerosis. Contrarily, the gene expression profile of ICAM-1 did not show any apparent differences between the groups, questioning the involvement of this molecule in the early development of atherosclerosis. Plasma levels of sVCAM-1 and sICAM-1 were similar in all mice and did not correlate with the vascular gene expression of the corresponding genes. It therefore seems likely that these circulating markers are not suited to detect early atherosclerosis.

U2 - 10.1016/j.bbrc.2008.10.037

DO - 10.1016/j.bbrc.2008.10.037

M3 - Journal article

C2 - 18930708

SN - 0006-291X

VL - 377/2

SP - 689

EP - 693

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

ER -

Gene expression of LOX-1, VCAM-1, and ICAM-1 in pre-atherosclerotic mice.

Abstract

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