Gender differences in cadmium and cotinine levels in prepubertal children

A Fucic; D Plavec; L Casteleyn; D Aerts; P Biot; A Katsonouri; M Cerna; Lisbeth E. Knudsen; A Castano; P Rudnai; A Gutleb; D Ligocka; I-R Lupsa; M Berglund; M Horvat; K Halzlova; G Schoeters; G Koppen; A Hadjipanayis; A Krskova; S Középesy; M Arendt; M E Fischer; B Janasik; A E Gurzau; E S Gurzau; M Grandér; K Larsson; M Jajcaj; M Kolossa-Gehring; O Sepai; K Exley; M Bartolome; F Cutanda; D Mazej; J K S Nielsen; J Snoj-Tratnik; G Schwedler; U Fiddicke; M Seiwert; E Govarts; E Den Hond; H M Koch; A Lopez; A Joas; R Joas

doi:10.1016/j.envres.2014.10.008

Gender differences in cadmium and cotinine levels in prepubertal children

A Fucic, D Plavec, L Casteleyn, D Aerts, P Biot, A Katsonouri, M Cerna, Lisbeth E. Knudsen, A Castano, P Rudnai, A Gutleb, D Ligocka, I-R Lupsa, M Berglund, M Horvat, K Halzlova, G Schoeters, G Koppen, A Hadjipanayis, A KrskovaS Középesy, M Arendt, M E Fischer, B Janasik, A E Gurzau, E S Gurzau, M Grandér, K Larsson, M Jajcaj, M Kolossa-Gehring, O Sepai, K Exley, M Bartolome, F Cutanda, D Mazej, J K S Nielsen, J Snoj-Tratnik, G Schwedler, U Fiddicke, M Seiwert, E Govarts, E Den Hond, H M Koch, A Lopez, A Joas, R Joas

4 Citations (Scopus)

Abstract

Susceptibility to environmental stressors has been described for fetal and early childhood development. However, the possible susceptibility of the prepubertal period, characterized by the orchestration of the organism towards sexual maturation and adulthood has been poorly investigated and exposure data are scarce. In the current study levels of cadmium (Cd), cotinine and creatinine in urine were analyzed in a subsample 216 children from 12 European countries within the DEMOCOPHES project. The children were divided into six age-sex groups: boys (6-8 years, 9-10 years and 11 years old), and girls (6-7 years, 8-9 years, 10-11 years). The number of subjects per group was between 23 and 53. The cut off values were set at 0.1µg/L for Cd, and 0.8µg/L for cotinine defined according to the highest limit of quantification. The levels of Cd and cotinine were adjusted for creatinine level. In the total subsample group, the median level of Cd was 0.180µg/L (range 0.10-0.69µg/L), and for cotinine the median wet weight value was 1.50µg/L (range 0.80-39.91µg/L). There was no significant difference in creatinine and cotinine levels between genders and age groups. There was a significant correlation between levels of cadmium and creatinine in all children of both genders. This shows that even at such low levels the possible effect of cadmium on kidney function was present and measurable. An increase in Cd levels was evident with age. Cadmium levels were significantly different between 6-7 year old girls, 11 year old boys and 10-11 year old girls. As there was a balanced distribution in the number of subjects from countries included in the study, bias due to data clustering was not probable. The impact of low Cd levels on kidney function and gender differences in Cd levels needs further investigation.

Original language	English
Journal	Environmental Research
Volume	141
Pages (from-to)	125–131
Number of pages	7
ISSN	0013-9351
DOIs	https://doi.org/10.1016/j.envres.2014.10.008
Publication status	Published - 1 Aug 2015

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10.1016/j.envres.2014.10.008

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Fucic, A., Plavec, D., Casteleyn, L., Aerts, D., Biot, P., Katsonouri, A., Cerna, M., Knudsen, L. E., Castano, A., Rudnai, P., Gutleb, A., Ligocka, D., Lupsa, I.-R., Berglund, M., Horvat, M., Halzlova, K., Schoeters, G., Koppen, G., Hadjipanayis, A., ... Joas, R. (2015). Gender differences in cadmium and cotinine levels in prepubertal children. Environmental Research, 141, 125–131. https://doi.org/10.1016/j.envres.2014.10.008

Fucic, A, Plavec, D, Casteleyn, L, Aerts, D, Biot, P, Katsonouri, A, Cerna, M, Knudsen, LE, Castano, A, Rudnai, P, Gutleb, A, Ligocka, D, Lupsa, I-R, Berglund, M, Horvat, M, Halzlova, K, Schoeters, G, Koppen, G, Hadjipanayis, A, Krskova, A, Középesy, S, Arendt, M, Fischer, ME, Janasik, B, Gurzau, AE, Gurzau, ES, Grandér, M, Larsson, K, Jajcaj, M, Kolossa-Gehring, M, Sepai, O, Exley, K, Bartolome, M, Cutanda, F, Mazej, D, Nielsen, JKS, Snoj-Tratnik, J, Schwedler, G, Fiddicke, U, Seiwert, M, Govarts, E, Den Hond, E, Koch, HM, Lopez, A, Joas, A & Joas, R 2015, 'Gender differences in cadmium and cotinine levels in prepubertal children', Environmental Research, vol. 141, pp. 125–131. https://doi.org/10.1016/j.envres.2014.10.008

@article{4723526d16e94b368a2744c088d146b4,

title = "Gender differences in cadmium and cotinine levels in prepubertal children",

abstract = "Susceptibility to environmental stressors has been described for fetal and early childhood development. However, the possible susceptibility of the prepubertal period, characterized by the orchestration of the organism towards sexual maturation and adulthood has been poorly investigated and exposure data are scarce. In the current study levels of cadmium (Cd), cotinine and creatinine in urine were analyzed in a subsample 216 children from 12 European countries within the DEMOCOPHES project. The children were divided into six age-sex groups: boys (6-8 years, 9-10 years and 11 years old), and girls (6-7 years, 8-9 years, 10-11 years). The number of subjects per group was between 23 and 53. The cut off values were set at 0.1µg/L for Cd, and 0.8µg/L for cotinine defined according to the highest limit of quantification. The levels of Cd and cotinine were adjusted for creatinine level. In the total subsample group, the median level of Cd was 0.180µg/L (range 0.10-0.69µg/L), and for cotinine the median wet weight value was 1.50µg/L (range 0.80-39.91µg/L). There was no significant difference in creatinine and cotinine levels between genders and age groups. There was a significant correlation between levels of cadmium and creatinine in all children of both genders. This shows that even at such low levels the possible effect of cadmium on kidney function was present and measurable. An increase in Cd levels was evident with age. Cadmium levels were significantly different between 6-7 year old girls, 11 year old boys and 10-11 year old girls. As there was a balanced distribution in the number of subjects from countries included in the study, bias due to data clustering was not probable. The impact of low Cd levels on kidney function and gender differences in Cd levels needs further investigation.",

author = "A Fucic and D Plavec and L Casteleyn and D Aerts and P Biot and A Katsonouri and M Cerna and Knudsen, {Lisbeth E.} and A Castano and P Rudnai and A Gutleb and D Ligocka and I-R Lupsa and M Berglund and M Horvat and K Halzlova and G Schoeters and G Koppen and A Hadjipanayis and A Krskova and S K{\"o}z{\'e}pesy and M Arendt and Fischer, {M E} and B Janasik and Gurzau, {A E} and Gurzau, {E S} and M Grand{\'e}r and K Larsson and M Jajcaj and M Kolossa-Gehring and O Sepai and K Exley and M Bartolome and F Cutanda and D Mazej and Nielsen, {J K S} and J Snoj-Tratnik and G Schwedler and U Fiddicke and M Seiwert and E Govarts and {Den Hond}, E and Koch, {H M} and A Lopez and A Joas and R Joas",

year = "2015",

month = aug,

day = "1",

doi = "10.1016/j.envres.2014.10.008",

language = "English",

volume = "141",

pages = "125–131",

journal = "Environmental Research",

issn = "0013-9351",

publisher = "Academic Press",

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TY - JOUR

T1 - Gender differences in cadmium and cotinine levels in prepubertal children

AU - Fucic, A

AU - Plavec, D

AU - Casteleyn, L

AU - Aerts, D

AU - Biot, P

AU - Katsonouri, A

AU - Cerna, M

AU - Knudsen, Lisbeth E.

AU - Castano, A

AU - Rudnai, P

AU - Gutleb, A

AU - Ligocka, D

AU - Lupsa, I-R

AU - Berglund, M

AU - Horvat, M

AU - Halzlova, K

AU - Schoeters, G

AU - Koppen, G

AU - Hadjipanayis, A

AU - Krskova, A

AU - Középesy, S

AU - Arendt, M

AU - Fischer, M E

AU - Janasik, B

AU - Gurzau, A E

AU - Gurzau, E S

AU - Grandér, M

AU - Larsson, K

AU - Jajcaj, M

AU - Kolossa-Gehring, M

AU - Sepai, O

AU - Exley, K

AU - Bartolome, M

AU - Cutanda, F

AU - Mazej, D

AU - Nielsen, J K S

AU - Snoj-Tratnik, J

AU - Schwedler, G

AU - Fiddicke, U

AU - Seiwert, M

AU - Govarts, E

AU - Den Hond, E

AU - Koch, H M

AU - Lopez, A

AU - Joas, A

AU - Joas, R

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Susceptibility to environmental stressors has been described for fetal and early childhood development. However, the possible susceptibility of the prepubertal period, characterized by the orchestration of the organism towards sexual maturation and adulthood has been poorly investigated and exposure data are scarce. In the current study levels of cadmium (Cd), cotinine and creatinine in urine were analyzed in a subsample 216 children from 12 European countries within the DEMOCOPHES project. The children were divided into six age-sex groups: boys (6-8 years, 9-10 years and 11 years old), and girls (6-7 years, 8-9 years, 10-11 years). The number of subjects per group was between 23 and 53. The cut off values were set at 0.1µg/L for Cd, and 0.8µg/L for cotinine defined according to the highest limit of quantification. The levels of Cd and cotinine were adjusted for creatinine level. In the total subsample group, the median level of Cd was 0.180µg/L (range 0.10-0.69µg/L), and for cotinine the median wet weight value was 1.50µg/L (range 0.80-39.91µg/L). There was no significant difference in creatinine and cotinine levels between genders and age groups. There was a significant correlation between levels of cadmium and creatinine in all children of both genders. This shows that even at such low levels the possible effect of cadmium on kidney function was present and measurable. An increase in Cd levels was evident with age. Cadmium levels were significantly different between 6-7 year old girls, 11 year old boys and 10-11 year old girls. As there was a balanced distribution in the number of subjects from countries included in the study, bias due to data clustering was not probable. The impact of low Cd levels on kidney function and gender differences in Cd levels needs further investigation.

AB - Susceptibility to environmental stressors has been described for fetal and early childhood development. However, the possible susceptibility of the prepubertal period, characterized by the orchestration of the organism towards sexual maturation and adulthood has been poorly investigated and exposure data are scarce. In the current study levels of cadmium (Cd), cotinine and creatinine in urine were analyzed in a subsample 216 children from 12 European countries within the DEMOCOPHES project. The children were divided into six age-sex groups: boys (6-8 years, 9-10 years and 11 years old), and girls (6-7 years, 8-9 years, 10-11 years). The number of subjects per group was between 23 and 53. The cut off values were set at 0.1µg/L for Cd, and 0.8µg/L for cotinine defined according to the highest limit of quantification. The levels of Cd and cotinine were adjusted for creatinine level. In the total subsample group, the median level of Cd was 0.180µg/L (range 0.10-0.69µg/L), and for cotinine the median wet weight value was 1.50µg/L (range 0.80-39.91µg/L). There was no significant difference in creatinine and cotinine levels between genders and age groups. There was a significant correlation between levels of cadmium and creatinine in all children of both genders. This shows that even at such low levels the possible effect of cadmium on kidney function was present and measurable. An increase in Cd levels was evident with age. Cadmium levels were significantly different between 6-7 year old girls, 11 year old boys and 10-11 year old girls. As there was a balanced distribution in the number of subjects from countries included in the study, bias due to data clustering was not probable. The impact of low Cd levels on kidney function and gender differences in Cd levels needs further investigation.

U2 - 10.1016/j.envres.2014.10.008

DO - 10.1016/j.envres.2014.10.008

M3 - Journal article

C2 - 25529752

SN - 0013-9351

VL - 141

SP - 125

EP - 131

JO - Environmental Research

JF - Environmental Research

ER -

Gender differences in cadmium and cotinine levels in prepubertal children

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