Gender, body mass index and rheumatoid arthritis disease activity: results from the QUEST-RA Study

D Jawaheer; J Olsen; M Lahiff; Susanne Forsberg; J Lähteenmäki; I G da Silveira; F A Rocha; I M Magalhães Laurindo; L M Henrique da Mota; A A Drosos; E Murphy; C Sheehy; E Quirke; M Cutolo; S Rexhepi; J Dadoniene; S M M Verstappen; T Sokka; Merete Lund Hetland; QUEST-RA

Gender, body mass index and rheumatoid arthritis disease activity: results from the QUEST-RA Study

D Jawaheer, J Olsen, M Lahiff, Susanne Forsberg, J Lähteenmäki, I G da Silveira, F A Rocha, I M Magalhães Laurindo, L M Henrique da Mota, A A Drosos, E Murphy, C Sheehy, E Quirke, M Cutolo, S Rexhepi, J Dadoniene, S M M Verstappen, T Sokka, Merete Lund Hetland, QUEST-RA

36 Citations (Scopus)

Abstract

Objective: To investigate whether body mass index (BMI), as a proxy for body fat, influences rheumatoid arthritis (RA) disease activity in a gender-specific manner. Methods: Consecutive patients with RA were enrolled from 25 countries into the QUEST-RA program between 2005 and 2008. Clinical and demographic data were collected by treating rheumatologists and by patient self-report. Distributions of Disease Activity Scores (DAS28), BMI, age, and disease duration were assessed for each country and for the entire dataset; mean values between genders were compared using Student's t-tests. An association between BMI and DAS28 was investigated using linear regression, adjusting for age, disease duration and country. Results: A total of 5,161 RA patients (4,082 women and 1,079 men) were included in the analyses. Overall, women were younger, had longer disease duration, and higher DAS28 scores than men, but BMI was similar between genders. The mean DAS28 scores increased with increasing BMI from normal to overweight and obese, among women, whereas the opposite trend was observed among men. Regression results showed BMI (continuous or categorical) to be associated with DAS28. Compared to the normal BMI range, being obese was associated with a larger difference in mean DAS28 (0.23, 95% CI: 0.11, 0.34) than being overweight (0.12, 95% CI: 0.03, 0.21); being underweight was not associated with disease activity. These associations were more pronounced among women, and were not explained by any single component of the DAS28. Conclusion: BMI appears to be associated with RA disease activity in women, but not in men.

Original language	English
Journal	Clinical and Experimental Rheumatology
Volume	28
Issue number	4
Pages (from-to)	454-61
Number of pages	8
ISSN	0392-856X
Publication status	Published - 2010

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Jawaheer, D., Olsen, J., Lahiff, M., Forsberg, S., Lähteenmäki, J., da Silveira, I. G., Rocha, F. A., Magalhães Laurindo, I. M., Henrique da Mota, L. M., Drosos, A. A., Murphy, E., Sheehy, C., Quirke, E., Cutolo, M., Rexhepi, S., Dadoniene, J., Verstappen, S. M. M., Sokka, T., Hetland, M. L., & QUEST-RA (2010). Gender, body mass index and rheumatoid arthritis disease activity: results from the QUEST-RA Study. Clinical and Experimental Rheumatology, 28(4), 454-61.

Jawaheer, D, Olsen, J, Lahiff, M, Forsberg, S, Lähteenmäki, J, da Silveira, IG, Rocha, FA, Magalhães Laurindo, IM, Henrique da Mota, LM, Drosos, AA, Murphy, E, Sheehy, C, Quirke, E, Cutolo, M, Rexhepi, S, Dadoniene, J, Verstappen, SMM, Sokka, T, Hetland, ML & QUEST-RA 2010, 'Gender, body mass index and rheumatoid arthritis disease activity: results from the QUEST-RA Study', Clinical and Experimental Rheumatology, vol. 28, no. 4, pp. 454-61.

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title = "Gender, body mass index and rheumatoid arthritis disease activity: results from the QUEST-RA Study",

abstract = "Objective: To investigate whether body mass index (BMI), as a proxy for body fat, influences rheumatoid arthritis (RA) disease activity in a gender-specific manner. Methods: Consecutive patients with RA were enrolled from 25 countries into the QUEST-RA program between 2005 and 2008. Clinical and demographic data were collected by treating rheumatologists and by patient self-report. Distributions of Disease Activity Scores (DAS28), BMI, age, and disease duration were assessed for each country and for the entire dataset; mean values between genders were compared using Student's t-tests. An association between BMI and DAS28 was investigated using linear regression, adjusting for age, disease duration and country. Results: A total of 5,161 RA patients (4,082 women and 1,079 men) were included in the analyses. Overall, women were younger, had longer disease duration, and higher DAS28 scores than men, but BMI was similar between genders. The mean DAS28 scores increased with increasing BMI from normal to overweight and obese, among women, whereas the opposite trend was observed among men. Regression results showed BMI (continuous or categorical) to be associated with DAS28. Compared to the normal BMI range, being obese was associated with a larger difference in mean DAS28 (0.23, 95% CI: 0.11, 0.34) than being overweight (0.12, 95% CI: 0.03, 0.21); being underweight was not associated with disease activity. These associations were more pronounced among women, and were not explained by any single component of the DAS28. Conclusion: BMI appears to be associated with RA disease activity in women, but not in men.",

author = "D Jawaheer and J Olsen and M Lahiff and Susanne Forsberg and J L{\"a}hteenm{\"a}ki and {da Silveira}, {I G} and Rocha, {F A} and {Magalh{\~a}es Laurindo}, {I M} and {Henrique da Mota}, {L M} and Drosos, {A A} and E Murphy and C Sheehy and E Quirke and M Cutolo and S Rexhepi and J Dadoniene and Verstappen, {S M M} and T Sokka and Hetland, {Merete Lund} and Olsen, {Johnny Baumann}",

year = "2010",

language = "English",

volume = "28",

pages = "454--61",

journal = "Clinical and Experimental Rheumatology",

issn = "0392-856X",

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TY - JOUR

T1 - Gender, body mass index and rheumatoid arthritis disease activity: results from the QUEST-RA Study

AU - Jawaheer, D

AU - Olsen, J

AU - Lahiff, M

AU - Forsberg, Susanne

AU - Lähteenmäki, J

AU - da Silveira, I G

AU - Rocha, F A

AU - Magalhães Laurindo, I M

AU - Henrique da Mota, L M

AU - Drosos, A A

AU - Murphy, E

AU - Sheehy, C

AU - Quirke, E

AU - Cutolo, M

AU - Rexhepi, S

AU - Dadoniene, J

AU - Verstappen, S M M

AU - Sokka, T

AU - Hetland, Merete Lund

AU - QUEST-RA

PY - 2010

Y1 - 2010

N2 - Objective: To investigate whether body mass index (BMI), as a proxy for body fat, influences rheumatoid arthritis (RA) disease activity in a gender-specific manner. Methods: Consecutive patients with RA were enrolled from 25 countries into the QUEST-RA program between 2005 and 2008. Clinical and demographic data were collected by treating rheumatologists and by patient self-report. Distributions of Disease Activity Scores (DAS28), BMI, age, and disease duration were assessed for each country and for the entire dataset; mean values between genders were compared using Student's t-tests. An association between BMI and DAS28 was investigated using linear regression, adjusting for age, disease duration and country. Results: A total of 5,161 RA patients (4,082 women and 1,079 men) were included in the analyses. Overall, women were younger, had longer disease duration, and higher DAS28 scores than men, but BMI was similar between genders. The mean DAS28 scores increased with increasing BMI from normal to overweight and obese, among women, whereas the opposite trend was observed among men. Regression results showed BMI (continuous or categorical) to be associated with DAS28. Compared to the normal BMI range, being obese was associated with a larger difference in mean DAS28 (0.23, 95% CI: 0.11, 0.34) than being overweight (0.12, 95% CI: 0.03, 0.21); being underweight was not associated with disease activity. These associations were more pronounced among women, and were not explained by any single component of the DAS28. Conclusion: BMI appears to be associated with RA disease activity in women, but not in men.

AB - Objective: To investigate whether body mass index (BMI), as a proxy for body fat, influences rheumatoid arthritis (RA) disease activity in a gender-specific manner. Methods: Consecutive patients with RA were enrolled from 25 countries into the QUEST-RA program between 2005 and 2008. Clinical and demographic data were collected by treating rheumatologists and by patient self-report. Distributions of Disease Activity Scores (DAS28), BMI, age, and disease duration were assessed for each country and for the entire dataset; mean values between genders were compared using Student's t-tests. An association between BMI and DAS28 was investigated using linear regression, adjusting for age, disease duration and country. Results: A total of 5,161 RA patients (4,082 women and 1,079 men) were included in the analyses. Overall, women were younger, had longer disease duration, and higher DAS28 scores than men, but BMI was similar between genders. The mean DAS28 scores increased with increasing BMI from normal to overweight and obese, among women, whereas the opposite trend was observed among men. Regression results showed BMI (continuous or categorical) to be associated with DAS28. Compared to the normal BMI range, being obese was associated with a larger difference in mean DAS28 (0.23, 95% CI: 0.11, 0.34) than being overweight (0.12, 95% CI: 0.03, 0.21); being underweight was not associated with disease activity. These associations were more pronounced among women, and were not explained by any single component of the DAS28. Conclusion: BMI appears to be associated with RA disease activity in women, but not in men.

M3 - Journal article

SN - 0392-856X

VL - 28

SP - 454

EP - 461

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

IS - 4

ER -

Gender, body mass index and rheumatoid arthritis disease activity: results from the QUEST-RA Study

Abstract

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