Gastric cancer risk in achlorhydric patients. A long-term follow-up study

Jesper Hastrup Svendsen; C Dahl; L B Svendsen; P M Christiansen

Gastric cancer risk in achlorhydric patients. A long-term follow-up study

Jesper Hastrup Svendsen, C Dahl, L B Svendsen, P M Christiansen

65 Citations (Scopus)

Abstract

Achlorhydria, determined by the augmented histamine test, is the functional expression of the most severe atrophic gastritis and is followed by a 4- to 6-fold increased risk of gastric cancer, as we found 5 cancers in 114 patients after a mean observation period of 8.4 years. The cancers developed from 1 to 17 years after achlorhydria diagnosis--three cases after more than 9 years. The study showed no difference in gastric cancer risk between patients with and without pernicious anaemia. Spontaneous achlorhydria is the late result of atrophic gastritis, which should be regarded the premalignant condition. The development of gastric cancer from pharmacologically reduced acid secretion must be regarded as highly hypothetical, since this is not followed by atrophic gastritis.

Original language	English
Journal	Scandinavian Journal of Gastroenterology
Volume	21
Issue number	1
Pages (from-to)	16-20
Number of pages	5
ISSN	0036-5521
Publication status	Published - 1 Jan 1986

Keywords

Achlorhydria
Adult
Aged
Denmark
Female
Follow-Up Studies
Humans
Male
Middle Aged
Risk
Stomach Neoplasms
Time Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Gastric cancer risk in achlorhydric patients. A long-term follow-up study",

abstract = "Achlorhydria, determined by the augmented histamine test, is the functional expression of the most severe atrophic gastritis and is followed by a 4- to 6-fold increased risk of gastric cancer, as we found 5 cancers in 114 patients after a mean observation period of 8.4 years. The cancers developed from 1 to 17 years after achlorhydria diagnosis--three cases after more than 9 years. The study showed no difference in gastric cancer risk between patients with and without pernicious anaemia. Spontaneous achlorhydria is the late result of atrophic gastritis, which should be regarded the premalignant condition. The development of gastric cancer from pharmacologically reduced acid secretion must be regarded as highly hypothetical, since this is not followed by atrophic gastritis.",

keywords = "Achlorhydria, Adult, Aged, Denmark, Female, Follow-Up Studies, Humans, Male, Middle Aged, Risk, Stomach Neoplasms, Time Factors",

author = "Svendsen, {Jesper Hastrup} and C Dahl and Svendsen, {L B} and Christiansen, {P M}",

year = "1986",

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day = "1",

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journal = "Scandinavian Journal of Gastroenterology",

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TY - JOUR

T1 - Gastric cancer risk in achlorhydric patients. A long-term follow-up study

AU - Svendsen, Jesper Hastrup

AU - Dahl, C

AU - Svendsen, L B

AU - Christiansen, P M

PY - 1986/1/1

Y1 - 1986/1/1

N2 - Achlorhydria, determined by the augmented histamine test, is the functional expression of the most severe atrophic gastritis and is followed by a 4- to 6-fold increased risk of gastric cancer, as we found 5 cancers in 114 patients after a mean observation period of 8.4 years. The cancers developed from 1 to 17 years after achlorhydria diagnosis--three cases after more than 9 years. The study showed no difference in gastric cancer risk between patients with and without pernicious anaemia. Spontaneous achlorhydria is the late result of atrophic gastritis, which should be regarded the premalignant condition. The development of gastric cancer from pharmacologically reduced acid secretion must be regarded as highly hypothetical, since this is not followed by atrophic gastritis.

AB - Achlorhydria, determined by the augmented histamine test, is the functional expression of the most severe atrophic gastritis and is followed by a 4- to 6-fold increased risk of gastric cancer, as we found 5 cancers in 114 patients after a mean observation period of 8.4 years. The cancers developed from 1 to 17 years after achlorhydria diagnosis--three cases after more than 9 years. The study showed no difference in gastric cancer risk between patients with and without pernicious anaemia. Spontaneous achlorhydria is the late result of atrophic gastritis, which should be regarded the premalignant condition. The development of gastric cancer from pharmacologically reduced acid secretion must be regarded as highly hypothetical, since this is not followed by atrophic gastritis.

KW - Achlorhydria

KW - Adult

KW - Aged

KW - Denmark

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Risk

KW - Stomach Neoplasms

KW - Time Factors

M3 - Journal article

C2 - 3952447

SN - 0036-5521

VL - 21

SP - 16

EP - 20

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

IS - 1

ER -

Gastric cancer risk in achlorhydric patients. A long-term follow-up study

Abstract

Keywords

UN SDGs

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