Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient

Arne Schousboe; Helle M Sickmann; Anne B Walls; Lasse K Bak; Helle S Waagepetersen

doi:10.1007/s12640-010-9171-5

Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient

Arne Schousboe, Helle M Sickmann, Anne B Walls, Lasse K Bak, Helle S Waagepetersen

30 Citations (Scopus)

Abstract

It has been proposed that a considerable fraction of glucose metabolism proceeds via the glycogen-shunt consisting of conversion of glucose units to glycogen residues and subsequent production of glucose-1-phosphate to be metabolized in glycolysis after conversion to glucose-6-phosphate. The importance of this as well as the significance of ATP formed in glycolysis versus that formed by the concerted action of the tricarboxylic acid (TCA) cycle processes and oxidative phosphorylation for maintenance of glutamate transport capacity in astrocytes is discussed. It is argued that glycolytically derived energy in the form of ATP may be of particular functional importance in this context.

Original language	English
Journal	Neurotoxicity Research
Volume	18
Issue number	1
Pages (from-to)	94-9
Number of pages	5
ISSN	1029-8428
DOIs	https://doi.org/10.1007/s12640-010-9171-5
Publication status	Published - Jul 2010

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Former Faculty of Pharmaceutical Sciences

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abstract = "It has been proposed that a considerable fraction of glucose metabolism proceeds via the glycogen-shunt consisting of conversion of glucose units to glycogen residues and subsequent production of glucose-1-phosphate to be metabolized in glycolysis after conversion to glucose-6-phosphate. The importance of this as well as the significance of ATP formed in glycolysis versus that formed by the concerted action of the tricarboxylic acid (TCA) cycle processes and oxidative phosphorylation for maintenance of glutamate transport capacity in astrocytes is discussed. It is argued that glycolytically derived energy in the form of ATP may be of particular functional importance in this context.",

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T1 - Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient

AU - Schousboe, Arne

AU - Sickmann, Helle M

AU - Walls, Anne B

AU - Bak, Lasse K

AU - Waagepetersen, Helle S

PY - 2010/7

Y1 - 2010/7

N2 - It has been proposed that a considerable fraction of glucose metabolism proceeds via the glycogen-shunt consisting of conversion of glucose units to glycogen residues and subsequent production of glucose-1-phosphate to be metabolized in glycolysis after conversion to glucose-6-phosphate. The importance of this as well as the significance of ATP formed in glycolysis versus that formed by the concerted action of the tricarboxylic acid (TCA) cycle processes and oxidative phosphorylation for maintenance of glutamate transport capacity in astrocytes is discussed. It is argued that glycolytically derived energy in the form of ATP may be of particular functional importance in this context.

AB - It has been proposed that a considerable fraction of glucose metabolism proceeds via the glycogen-shunt consisting of conversion of glucose units to glycogen residues and subsequent production of glucose-1-phosphate to be metabolized in glycolysis after conversion to glucose-6-phosphate. The importance of this as well as the significance of ATP formed in glycolysis versus that formed by the concerted action of the tricarboxylic acid (TCA) cycle processes and oxidative phosphorylation for maintenance of glutamate transport capacity in astrocytes is discussed. It is argued that glycolytically derived energy in the form of ATP may be of particular functional importance in this context.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1007/s12640-010-9171-5

DO - 10.1007/s12640-010-9171-5

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JO - Neurotoxicity Research

JF - Neurotoxicity Research

IS - 1

ER -

Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient

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