Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder

Vibe G Frokjaer; Erik Lykke Mortensen; Finn A Nielsen; Steven Haugbol; Lars H Pinborg; Karen H Adams; Claus Svarer; Steen Hasselbalch; Soeren Holm; Olaf B Paulson; Gitte M Knudsen

doi:10.1016/j.biopsych.2007.07.009

Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder

Vibe G Frokjaer, Erik Lykke Mortensen, Finn A Nielsen, Steven Haugbol, Lars H Pinborg, Karen H Adams, Claus Svarer, Steen Hasselbalch, Soeren Holm, Olaf B Paulson, Gitte M Knudsen

138 Citations (Scopus)

Abstract

BACKGROUND: Serotonergic dysfunction has been associated with affective disorders. High trait neuroticism, as measured on personality inventories, is a risk factor for major depression. In this study we investigated whether neuroticism is associated with serotonin 2A receptor binding in brain regions of relevance for affective disorders. METHODS: Eighty-three healthy volunteers completed the standardized personality questionnaire NEO-PI-R (Revised NEO Personality Inventory) and underwent [(18)F]altanserin positron emission tomography imaging for assessment of serotonin 2A receptor binding. The correlation between the neuroticism score and frontolimbic serotonin 2A receptor binding was evaluated by multiple linear regression analysis with adjustment for age and gender. RESULTS: Neuroticism correlated positively with frontolimbic serotonin 2A receptor binding [r(79) = .24, p = .028]. Post hoc analysis of the contributions from the six constituent traits of neuroticism showed that the correlation was primarily driven by two of them: vulnerability and anxiety. Indeed, vulnerability, defined as a person's difficulties in coping with stress, displayed the strongest positive correlation, which remained significant after correction for multiple comparisons (r = .35, p = .009). CONCLUSIONS: In healthy subjects the personality dimension neuroticism and particularly its constituent trait, vulnerability, are positively associated with frontolimbic serotonin 2A binding. Our findings point to a neurobiological link between personality risk factors for affective disorder and the serotonergic transmitter system and identify the serotonin 2A receptor as a biomarker for vulnerability to affective disorder.

Original language	English
Journal	Biological Psychiatry
Volume	63
Issue number	6
Pages (from-to)	569-76
Number of pages	7
ISSN	0006-3223
DOIs	https://doi.org/10.1016/j.biopsych.2007.07.009
Publication status	Published - 2008

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Frokjaer, V. G., Mortensen, E. L., Nielsen, F. A., Haugbol, S., Pinborg, L. H., Adams, K. H., Svarer, C., Hasselbalch, S., Holm, S., Paulson, O. B., & Knudsen, G. M. (2008). Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder. Biological Psychiatry, 63(6), 569-76. https://doi.org/10.1016/j.biopsych.2007.07.009

Frokjaer, VG, Mortensen, EL, Nielsen, FA, Haugbol, S, Pinborg, LH, Adams, KH, Svarer, C, Hasselbalch, S, Holm, S, Paulson, OB & Knudsen, GM 2008, 'Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder', Biological Psychiatry, vol. 63, no. 6, pp. 569-76. https://doi.org/10.1016/j.biopsych.2007.07.009

@article{b21ed510eba111ddbf70000ea68e967b,

title = "Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder",

abstract = "BACKGROUND: Serotonergic dysfunction has been associated with affective disorders. High trait neuroticism, as measured on personality inventories, is a risk factor for major depression. In this study we investigated whether neuroticism is associated with serotonin 2A receptor binding in brain regions of relevance for affective disorders. METHODS: Eighty-three healthy volunteers completed the standardized personality questionnaire NEO-PI-R (Revised NEO Personality Inventory) and underwent [(18)F]altanserin positron emission tomography imaging for assessment of serotonin 2A receptor binding. The correlation between the neuroticism score and frontolimbic serotonin 2A receptor binding was evaluated by multiple linear regression analysis with adjustment for age and gender. RESULTS: Neuroticism correlated positively with frontolimbic serotonin 2A receptor binding [r(79) = .24, p = .028]. Post hoc analysis of the contributions from the six constituent traits of neuroticism showed that the correlation was primarily driven by two of them: vulnerability and anxiety. Indeed, vulnerability, defined as a person's difficulties in coping with stress, displayed the strongest positive correlation, which remained significant after correction for multiple comparisons (r = .35, p = .009). CONCLUSIONS: In healthy subjects the personality dimension neuroticism and particularly its constituent trait, vulnerability, are positively associated with frontolimbic serotonin 2A binding. Our findings point to a neurobiological link between personality risk factors for affective disorder and the serotonergic transmitter system and identify the serotonin 2A receptor as a biomarker for vulnerability to affective disorder.",

author = "Frokjaer, {Vibe G} and Mortensen, {Erik Lykke} and Nielsen, {Finn A} and Steven Haugbol and Pinborg, {Lars H} and Adams, {Karen H} and Claus Svarer and Steen Hasselbalch and Soeren Holm and Paulson, {Olaf B} and Knudsen, {Gitte M}",

note = "Keywords: Adolescent; Adult; Aged; Biological Markers; Character; Depressive Disorder, Major; Dominance, Cerebral; Female; Fluorine Radioisotopes; Frontal Lobe; Gyrus Cinguli; Humans; Image Processing, Computer-Assisted; Ketanserin; Limbic System; Magnetic Resonance Imaging; Male; Middle Aged; Neurotic Disorders; Personality Inventory; Positron-Emission Tomography; Receptor, Serotonin, 5-HT2A; Reference Values; Risk Factors; Statistics as Topic; Temporal Lobe",

year = "2008",

doi = "10.1016/j.biopsych.2007.07.009",

language = "English",

volume = "63",

pages = "569--76",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "Elsevier",

number = "6",

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TY - JOUR

T1 - Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder

AU - Frokjaer, Vibe G

AU - Mortensen, Erik Lykke

AU - Nielsen, Finn A

AU - Haugbol, Steven

AU - Pinborg, Lars H

AU - Adams, Karen H

AU - Svarer, Claus

AU - Hasselbalch, Steen

AU - Holm, Soeren

AU - Paulson, Olaf B

AU - Knudsen, Gitte M

N1 - Keywords: Adolescent; Adult; Aged; Biological Markers; Character; Depressive Disorder, Major; Dominance, Cerebral; Female; Fluorine Radioisotopes; Frontal Lobe; Gyrus Cinguli; Humans; Image Processing, Computer-Assisted; Ketanserin; Limbic System; Magnetic Resonance Imaging; Male; Middle Aged; Neurotic Disorders; Personality Inventory; Positron-Emission Tomography; Receptor, Serotonin, 5-HT2A; Reference Values; Risk Factors; Statistics as Topic; Temporal Lobe

PY - 2008

Y1 - 2008

N2 - BACKGROUND: Serotonergic dysfunction has been associated with affective disorders. High trait neuroticism, as measured on personality inventories, is a risk factor for major depression. In this study we investigated whether neuroticism is associated with serotonin 2A receptor binding in brain regions of relevance for affective disorders. METHODS: Eighty-three healthy volunteers completed the standardized personality questionnaire NEO-PI-R (Revised NEO Personality Inventory) and underwent [(18)F]altanserin positron emission tomography imaging for assessment of serotonin 2A receptor binding. The correlation between the neuroticism score and frontolimbic serotonin 2A receptor binding was evaluated by multiple linear regression analysis with adjustment for age and gender. RESULTS: Neuroticism correlated positively with frontolimbic serotonin 2A receptor binding [r(79) = .24, p = .028]. Post hoc analysis of the contributions from the six constituent traits of neuroticism showed that the correlation was primarily driven by two of them: vulnerability and anxiety. Indeed, vulnerability, defined as a person's difficulties in coping with stress, displayed the strongest positive correlation, which remained significant after correction for multiple comparisons (r = .35, p = .009). CONCLUSIONS: In healthy subjects the personality dimension neuroticism and particularly its constituent trait, vulnerability, are positively associated with frontolimbic serotonin 2A binding. Our findings point to a neurobiological link between personality risk factors for affective disorder and the serotonergic transmitter system and identify the serotonin 2A receptor as a biomarker for vulnerability to affective disorder.

AB - BACKGROUND: Serotonergic dysfunction has been associated with affective disorders. High trait neuroticism, as measured on personality inventories, is a risk factor for major depression. In this study we investigated whether neuroticism is associated with serotonin 2A receptor binding in brain regions of relevance for affective disorders. METHODS: Eighty-three healthy volunteers completed the standardized personality questionnaire NEO-PI-R (Revised NEO Personality Inventory) and underwent [(18)F]altanserin positron emission tomography imaging for assessment of serotonin 2A receptor binding. The correlation between the neuroticism score and frontolimbic serotonin 2A receptor binding was evaluated by multiple linear regression analysis with adjustment for age and gender. RESULTS: Neuroticism correlated positively with frontolimbic serotonin 2A receptor binding [r(79) = .24, p = .028]. Post hoc analysis of the contributions from the six constituent traits of neuroticism showed that the correlation was primarily driven by two of them: vulnerability and anxiety. Indeed, vulnerability, defined as a person's difficulties in coping with stress, displayed the strongest positive correlation, which remained significant after correction for multiple comparisons (r = .35, p = .009). CONCLUSIONS: In healthy subjects the personality dimension neuroticism and particularly its constituent trait, vulnerability, are positively associated with frontolimbic serotonin 2A binding. Our findings point to a neurobiological link between personality risk factors for affective disorder and the serotonergic transmitter system and identify the serotonin 2A receptor as a biomarker for vulnerability to affective disorder.

U2 - 10.1016/j.biopsych.2007.07.009

DO - 10.1016/j.biopsych.2007.07.009

M3 - Journal article

C2 - 17884017

SN - 0006-3223

VL - 63

SP - 569

EP - 576

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 6

ER -

Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder

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