TY - JOUR
T1 - From Dietary Fiber to Host Physiology
T2 - Short-Chain Fatty Acids as Key Bacterial Metabolites
AU - Koh, Ara
AU - De Vadder, Filipe
AU - Kovatcheva-Datchary, Petia
AU - Bäckhed, Gert Fredrik
N1 - Copyright © 2016 Elsevier Inc. All rights reserved.
PY - 2016/6/2
Y1 - 2016/6/2
N2 - A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis? A growing body of work implicates microbially produced metabolites as crucial executors of diet-based microbial influence on the host. Here, we will review data supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs). SCFAs can directly activate G-coupled-receptors, inhibit histone deacetylases, and serve as energy substrates. They thus affect various physiological processes and may contribute to health and disease.
AB - A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis? A growing body of work implicates microbially produced metabolites as crucial executors of diet-based microbial influence on the host. Here, we will review data supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs). SCFAs can directly activate G-coupled-receptors, inhibit histone deacetylases, and serve as energy substrates. They thus affect various physiological processes and may contribute to health and disease.
KW - Journal Article
KW - Review
U2 - 10.1016/j.cell.2016.05.041
DO - 10.1016/j.cell.2016.05.041
M3 - Journal article
C2 - 27259147
SN - 0092-8674
VL - 165
SP - 1332
EP - 1345
JO - Cell
JF - Cell
IS - 6
ER -