Friction-limited cell motility in confluent monolayer tissue

TY - JOUR

T1 - Friction-limited cell motility in confluent monolayer tissue

AU - Christensen, Amalie

AU - West, Ann-Katrine Vransø

AU - Wullkopf, Lena

AU - Erler, Janine Terra

AU - Oddershede, Lene Broeng

AU - Mathiesen, Joachim

PY - 2018/7/25

Y1 - 2018/7/25

N2 - Mechanical forces are important factors in the development, coordination and collective motion of cells. Based on a continuum-scale model, we consider the influence of substrate friction on cell motility in confluent living tissue. We test our model on the experimental data of endothelial and cancer cells. In contrast to the commonly used drag friction, we find that solid friction best captures the cell speed distribution. From our model, we quantify a number of measurable physical tissue parameters, such as the ratio between the viscosity and substrate friction.

AB - Mechanical forces are important factors in the development, coordination and collective motion of cells. Based on a continuum-scale model, we consider the influence of substrate friction on cell motility in confluent living tissue. We test our model on the experimental data of endothelial and cancer cells. In contrast to the commonly used drag friction, we find that solid friction best captures the cell speed distribution. From our model, we quantify a number of measurable physical tissue parameters, such as the ratio between the viscosity and substrate friction.

U2 - 10.1088/1478-3975/aacedc

DO - 10.1088/1478-3975/aacedc

M3 - Journal article

C2 - 29939152

SN - 1478-3967

VL - 15

JO - Physical Biology

JF - Physical Biology

IS - 6

M1 - 066004

ER -