Frequency and risk factors of gastric and duodenal ulcers or erosions in children: a prospective 1-month European multicenter study

Nicolas Kalach; Patrick Bontems; Sibylle Koletzko; Petronella Mourad-Baars; Peter Shcherbakov; Danuta Celinska-Cedro; Barbara Iwanczak; Frederic Gottrand; Maria Jose Martinez-Gomez; Ender Pehlivanoglu; Giuseppina Oderda; Pedro Urruzuno; Thomas Casswall; Thierry Lamireau; Josef Sykora; Elefteria Roma-Giannikou; Gabor Veres; Vibeke Wewer; Sonny Chong; Marie Laure Charkaluk; Francis Mégraud; Samy Cadranel

doi:10.1097/meg.0b013e32833d36de

Frequency and risk factors of gastric and duodenal ulcers or erosions in children: a prospective 1-month European multicenter study

Nicolas Kalach, Patrick Bontems, Sibylle Koletzko, Petronella Mourad-Baars, Peter Shcherbakov, Danuta Celinska-Cedro, Barbara Iwanczak, Frederic Gottrand, Maria Jose Martinez-Gomez, Ender Pehlivanoglu, Giuseppina Oderda, Pedro Urruzuno, Thomas Casswall, Thierry Lamireau, Josef Sykora, Elefteria Roma-Giannikou, Gabor Veres, Vibeke Wewer, Sonny Chong, Marie Laure CharkalukFrancis Mégraud, Samy Cadranel

Department of Clinical Medicine

31 Citations (Scopus)

Abstract

There are no solid figures of the frequency of ulcer disease during childhood in Europe. We assessed its frequency and analyzed known risk factors. PATIENTS AND Methods: Ulcers, erosions, indications, and risk factors were recorded in all children undergoing an upper gastrointestinal endoscopy in a prospective study carried out during 1-month simultaneously in 19 centers among 14 European countries. Results: Ulcers and/or erosions were observed in 56 out of 694 children. Children with ulcers/erosions were significantly older than those without lesions (10.3±5.5 vs. 8.1±5.7 years, P=0.002). Helicobacter pylori infection was present in 15 of 56 children (27%) where NSAIDs were used in eight, steroids in five, immune-suppressive drugs in five, antibiotics in six, antacids in one, H2-blockers in six and proton pump inhibitors in eight children (more than one risk factor was detected in 32 of 56 children). No risk factors were observed in 24 of 56 children (43%). The main indications for endoscopy were epigastric or abdominal pain (24%) and suspicion of gastroesophageal reflux disease (15%). Similarly, epigastric tenderness, hematemesis, melena, and weight stagnation were significantly associated with ulcers/erosions, whereas sex, H. pylori infection, socioeconomic and lifestyle factors were equally distributed. Conxlusion: Although limited by the short-time duration and the heterogeneity of the patients included throughout the 19 centers, our study shows a frequency of 8.1% of ulcers and/or erosions in children, occurring mainly in the second decade of life. H. pylori infection and gastrotoxic medications were less frequently implicated than expected.

Original language	English
Journal	European journal of gastroenterology & hepatology
Volume	22
Issue number	10
Pages (from-to)	1174-81
Number of pages	7
DOIs	https://doi.org/10.1097/meg.0b013e32833d36de
Publication status	Published - Oct 2010

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Kalach, N., Bontems, P., Koletzko, S., Mourad-Baars, P., Shcherbakov, P., Celinska-Cedro, D., Iwanczak, B., Gottrand, F., Martinez-Gomez, M. J., Pehlivanoglu, E., Oderda, G., Urruzuno, P., Casswall, T., Lamireau, T., Sykora, J., Roma-Giannikou, E., Veres, G., Wewer, V., Chong, S., ... Cadranel, S. (2010). Frequency and risk factors of gastric and duodenal ulcers or erosions in children: a prospective 1-month European multicenter study. European journal of gastroenterology & hepatology, 22(10), 1174-81. https://doi.org/10.1097/meg.0b013e32833d36de

Frequency and risk factors of gastric and duodenal ulcers or erosions in children: a prospective 1-month European multicenter study. / Kalach, Nicolas; Bontems, Patrick; Koletzko, Sibylle et al.

In: European journal of gastroenterology & hepatology, Vol. 22, No. 10, 10.2010, p. 1174-81.

Research output: Contribution to journal › Journal article › Research › peer-review

Kalach, N, Bontems, P, Koletzko, S, Mourad-Baars, P, Shcherbakov, P, Celinska-Cedro, D, Iwanczak, B, Gottrand, F, Martinez-Gomez, MJ, Pehlivanoglu, E, Oderda, G, Urruzuno, P, Casswall, T, Lamireau, T, Sykora, J, Roma-Giannikou, E, Veres, G, Wewer, V, Chong, S, Charkaluk, ML, Mégraud, F & Cadranel, S 2010, 'Frequency and risk factors of gastric and duodenal ulcers or erosions in children: a prospective 1-month European multicenter study', European journal of gastroenterology & hepatology, vol. 22, no. 10, pp. 1174-81. https://doi.org/10.1097/meg.0b013e32833d36de

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title = "Frequency and risk factors of gastric and duodenal ulcers or erosions in children: a prospective 1-month European multicenter study",

abstract = "There are no solid figures of the frequency of ulcer disease during childhood in Europe. We assessed its frequency and analyzed known risk factors. PATIENTS AND Methods: Ulcers, erosions, indications, and risk factors were recorded in all children undergoing an upper gastrointestinal endoscopy in a prospective study carried out during 1-month simultaneously in 19 centers among 14 European countries. Results: Ulcers and/or erosions were observed in 56 out of 694 children. Children with ulcers/erosions were significantly older than those without lesions (10.3±5.5 vs. 8.1±5.7 years, P=0.002). Helicobacter pylori infection was present in 15 of 56 children (27%) where NSAIDs were used in eight, steroids in five, immune-suppressive drugs in five, antibiotics in six, antacids in one, H2-blockers in six and proton pump inhibitors in eight children (more than one risk factor was detected in 32 of 56 children). No risk factors were observed in 24 of 56 children (43%). The main indications for endoscopy were epigastric or abdominal pain (24%) and suspicion of gastroesophageal reflux disease (15%). Similarly, epigastric tenderness, hematemesis, melena, and weight stagnation were significantly associated with ulcers/erosions, whereas sex, H. pylori infection, socioeconomic and lifestyle factors were equally distributed. Conxlusion: Although limited by the short-time duration and the heterogeneity of the patients included throughout the 19 centers, our study shows a frequency of 8.1% of ulcers and/or erosions in children, occurring mainly in the second decade of life. H. pylori infection and gastrotoxic medications were less frequently implicated than expected.",

author = "Nicolas Kalach and Patrick Bontems and Sibylle Koletzko and Petronella Mourad-Baars and Peter Shcherbakov and Danuta Celinska-Cedro and Barbara Iwanczak and Frederic Gottrand and Martinez-Gomez, {Maria Jose} and Ender Pehlivanoglu and Giuseppina Oderda and Pedro Urruzuno and Thomas Casswall and Thierry Lamireau and Josef Sykora and Elefteria Roma-Giannikou and Gabor Veres and Vibeke Wewer and Sonny Chong and Charkaluk, {Marie Laure} and Francis M{\'e}graud and Samy Cadranel",

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doi = "10.1097/meg.0b013e32833d36de",

language = "English",

volume = "22",

pages = "1174--81",

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T1 - Frequency and risk factors of gastric and duodenal ulcers or erosions in children: a prospective 1-month European multicenter study

AU - Kalach, Nicolas

AU - Bontems, Patrick

AU - Koletzko, Sibylle

AU - Mourad-Baars, Petronella

AU - Shcherbakov, Peter

AU - Celinska-Cedro, Danuta

AU - Iwanczak, Barbara

AU - Gottrand, Frederic

AU - Martinez-Gomez, Maria Jose

AU - Pehlivanoglu, Ender

AU - Oderda, Giuseppina

AU - Urruzuno, Pedro

AU - Casswall, Thomas

AU - Lamireau, Thierry

AU - Sykora, Josef

AU - Roma-Giannikou, Elefteria

AU - Veres, Gabor

AU - Wewer, Vibeke

AU - Chong, Sonny

AU - Charkaluk, Marie Laure

AU - Mégraud, Francis

AU - Cadranel, Samy

PY - 2010/10

Y1 - 2010/10

N2 - There are no solid figures of the frequency of ulcer disease during childhood in Europe. We assessed its frequency and analyzed known risk factors. PATIENTS AND Methods: Ulcers, erosions, indications, and risk factors were recorded in all children undergoing an upper gastrointestinal endoscopy in a prospective study carried out during 1-month simultaneously in 19 centers among 14 European countries. Results: Ulcers and/or erosions were observed in 56 out of 694 children. Children with ulcers/erosions were significantly older than those without lesions (10.3±5.5 vs. 8.1±5.7 years, P=0.002). Helicobacter pylori infection was present in 15 of 56 children (27%) where NSAIDs were used in eight, steroids in five, immune-suppressive drugs in five, antibiotics in six, antacids in one, H2-blockers in six and proton pump inhibitors in eight children (more than one risk factor was detected in 32 of 56 children). No risk factors were observed in 24 of 56 children (43%). The main indications for endoscopy were epigastric or abdominal pain (24%) and suspicion of gastroesophageal reflux disease (15%). Similarly, epigastric tenderness, hematemesis, melena, and weight stagnation were significantly associated with ulcers/erosions, whereas sex, H. pylori infection, socioeconomic and lifestyle factors were equally distributed. Conxlusion: Although limited by the short-time duration and the heterogeneity of the patients included throughout the 19 centers, our study shows a frequency of 8.1% of ulcers and/or erosions in children, occurring mainly in the second decade of life. H. pylori infection and gastrotoxic medications were less frequently implicated than expected.

AB - There are no solid figures of the frequency of ulcer disease during childhood in Europe. We assessed its frequency and analyzed known risk factors. PATIENTS AND Methods: Ulcers, erosions, indications, and risk factors were recorded in all children undergoing an upper gastrointestinal endoscopy in a prospective study carried out during 1-month simultaneously in 19 centers among 14 European countries. Results: Ulcers and/or erosions were observed in 56 out of 694 children. Children with ulcers/erosions were significantly older than those without lesions (10.3±5.5 vs. 8.1±5.7 years, P=0.002). Helicobacter pylori infection was present in 15 of 56 children (27%) where NSAIDs were used in eight, steroids in five, immune-suppressive drugs in five, antibiotics in six, antacids in one, H2-blockers in six and proton pump inhibitors in eight children (more than one risk factor was detected in 32 of 56 children). No risk factors were observed in 24 of 56 children (43%). The main indications for endoscopy were epigastric or abdominal pain (24%) and suspicion of gastroesophageal reflux disease (15%). Similarly, epigastric tenderness, hematemesis, melena, and weight stagnation were significantly associated with ulcers/erosions, whereas sex, H. pylori infection, socioeconomic and lifestyle factors were equally distributed. Conxlusion: Although limited by the short-time duration and the heterogeneity of the patients included throughout the 19 centers, our study shows a frequency of 8.1% of ulcers and/or erosions in children, occurring mainly in the second decade of life. H. pylori infection and gastrotoxic medications were less frequently implicated than expected.

U2 - 10.1097/meg.0b013e32833d36de

DO - 10.1097/meg.0b013e32833d36de

M3 - Journal article

SN - 0954-691X

VL - 22

SP - 1174

EP - 1181

JO - European Journal of Gastroenterology and Hepatology, Supplement

JF - European Journal of Gastroenterology and Hepatology, Supplement

IS - 10

ER -

Frequency and risk factors of gastric and duodenal ulcers or erosions in children: a prospective 1-month European multicenter study

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