Free leptin index and PAPP-A: a first trimester maternal serum screening test for pre-eclampsia

Paula L Hedley; Sophie Placing; Karen Wøjdemann; Anting Liu Carlsen; Anne-Cathrine Shalmi; Karin Sundberg; Ann Tabor; Michael Christiansen; Paula L Hedley; Sophie Placing; Karen Wøjdemann; Anting Liu Carlsen; Anne-Cathrine Shalmi; Karin Sundberg; Ann Tabor; Michael Christiansen

doi:10.1002/pd.2337

Free leptin index and PAPP-A: a first trimester maternal serum screening test for pre-eclampsia

Paula L Hedley, Sophie Placing, Karen Wøjdemann, Anting Liu Carlsen, Anne-Cathrine Shalmi, Karin Sundberg, Ann Tabor, Michael Christiansen, Paula L Hedley, Sophie Placing, Karen Wøjdemann, Anting Liu Carlsen, Anne-Cathrine Shalmi, Karin Sundberg, Ann Tabor, Michael Christiansen

17 Citations (Scopus)

Abstract

Background: Prophylaxis with low-dose aspirin may reduce the risk of pre-eclampsia (PE) if introduced in first trimester. The performance of first trimester maternal serum screening for PE using free leptin index (fLI) and PAPP-A, where fLI = leptin/leptin soluble receptor was studied. Methods: First trimester serum samples from 126 PE pregnancies and 289 control pregnancies were studied. fLI and PAPP-A were converted into gestational age and maternal weight independent log MoM values of PAPP-A and fLI. The screening performance of markers was studied by receiver-operator-characteristics curves. The performance of population screening was estimated by Monte Carlo simulation. Results: fLI was significantly (p < 0.001) elevated [mean log MoM 0.2165 (SD: 0.2604)] compared to controls [mean log MoM -0.0368 (SD: 0.3132)] and PAPP-A was significantly (p < 0.001) reduced [mean log MoM -0.0133 (SD: 0.2661)] compared to controls [mean log MoM 0.0474 (SD: 0.2521)] in PE pregnancies. There was no correlation between fLI and PAPP-A in control or PE pregnancies. Combined fLI and PAPP-A screening for PE had estimated population detection rates of 22% and 35% for false positives rates of 6% and 12%, respectively. Conclusion: Combining PAPP-A and fLI improves screening performance for PE compared to single marker screening.

Original language	English
Journal	Prenatal Diagnosis
Volume	30
Issue number	2
Pages (from-to)	103-9
Number of pages	7
ISSN	0197-3851
DOIs	https://doi.org/10.1002/pd.2337
Publication status	Published - 1 Feb 2010

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Hedley, P. L., Placing, S., Wøjdemann, K., Carlsen, A. L., Shalmi, A-C., Sundberg, K., Tabor, A., Christiansen, M., Hedley, P. L., Placing, S., Wøjdemann, K., Carlsen, A. L., Shalmi, A-C., Sundberg, K., Tabor, A., & Christiansen, M. (2010). Free leptin index and PAPP-A: a first trimester maternal serum screening test for pre-eclampsia. Prenatal Diagnosis, 30(2), 103-9. https://doi.org/10.1002/pd.2337

Hedley, PL, Placing, S, Wøjdemann, K, Carlsen, AL, Shalmi, A-C, Sundberg, K, Tabor, A, Christiansen, M, Hedley, PL, Placing, S, Wøjdemann, K, Carlsen, AL, Shalmi, A-C, Sundberg, K, Tabor, A & Christiansen, M 2010, 'Free leptin index and PAPP-A: a first trimester maternal serum screening test for pre-eclampsia', Prenatal Diagnosis, vol. 30, no. 2, pp. 103-9. https://doi.org/10.1002/pd.2337

@article{e929c6e067f211df928f000ea68e967b,

title = "Free leptin index and PAPP-A: a first trimester maternal serum screening test for pre-eclampsia",

abstract = "Background: Prophylaxis with low-dose aspirin may reduce the risk of pre-eclampsia (PE) if introduced in first trimester. The performance of first trimester maternal serum screening for PE using free leptin index (fLI) and PAPP-A, where fLI = leptin/leptin soluble receptor was studied. Methods: First trimester serum samples from 126 PE pregnancies and 289 control pregnancies were studied. fLI and PAPP-A were converted into gestational age and maternal weight independent log MoM values of PAPP-A and fLI. The screening performance of markers was studied by receiver-operator-characteristics curves. The performance of population screening was estimated by Monte Carlo simulation. Results: fLI was significantly (p < 0.001) elevated [mean log MoM 0.2165 (SD: 0.2604)] compared to controls [mean log MoM -0.0368 (SD: 0.3132)] and PAPP-A was significantly (p < 0.001) reduced [mean log MoM -0.0133 (SD: 0.2661)] compared to controls [mean log MoM 0.0474 (SD: 0.2521)] in PE pregnancies. There was no correlation between fLI and PAPP-A in control or PE pregnancies. Combined fLI and PAPP-A screening for PE had estimated population detection rates of 22% and 35% for false positives rates of 6% and 12%, respectively. Conclusion: Combining PAPP-A and fLI improves screening performance for PE compared to single marker screening.",

author = "Hedley, {Paula L} and Sophie Placing and Karen W{\o}jdemann and Carlsen, {Anting Liu} and Anne-Cathrine Shalmi and Karin Sundberg and Ann Tabor and Michael Christiansen and Hedley, {Paula L} and Sophie Placing and Karen W{\o}jdemann and Carlsen, {Anting Liu} and Anne-Cathrine Shalmi and Karin Sundberg and Ann Tabor and Michael Christiansen",

note = "Keywords: Adult; Biological Markers; Case-Control Studies; Female; Gestational Age; Humans; Leptin; Mass Screening; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, First; Pregnancy-Associated Plasma Protein-A; Prenatal Care; Risk Factors",

year = "2010",

month = feb,

day = "1",

doi = "10.1002/pd.2337",

language = "English",

volume = "30",

pages = "103--9",

journal = "Prenatal Diagnosis",

issn = "0197-3851",

publisher = "JohnWiley & Sons Ltd",

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TY - JOUR

T1 - Free leptin index and PAPP-A: a first trimester maternal serum screening test for pre-eclampsia

AU - Hedley, Paula L

AU - Placing, Sophie

AU - Wøjdemann, Karen

AU - Carlsen, Anting Liu

AU - Shalmi, Anne-Cathrine

AU - Sundberg, Karin

AU - Tabor, Ann

AU - Christiansen, Michael

AU - Hedley, Paula L

AU - Placing, Sophie

AU - Wøjdemann, Karen

AU - Carlsen, Anting Liu

AU - Shalmi, Anne-Cathrine

AU - Sundberg, Karin

AU - Tabor, Ann

AU - Christiansen, Michael

N1 - Keywords: Adult; Biological Markers; Case-Control Studies; Female; Gestational Age; Humans; Leptin; Mass Screening; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, First; Pregnancy-Associated Plasma Protein-A; Prenatal Care; Risk Factors

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Background: Prophylaxis with low-dose aspirin may reduce the risk of pre-eclampsia (PE) if introduced in first trimester. The performance of first trimester maternal serum screening for PE using free leptin index (fLI) and PAPP-A, where fLI = leptin/leptin soluble receptor was studied. Methods: First trimester serum samples from 126 PE pregnancies and 289 control pregnancies were studied. fLI and PAPP-A were converted into gestational age and maternal weight independent log MoM values of PAPP-A and fLI. The screening performance of markers was studied by receiver-operator-characteristics curves. The performance of population screening was estimated by Monte Carlo simulation. Results: fLI was significantly (p < 0.001) elevated [mean log MoM 0.2165 (SD: 0.2604)] compared to controls [mean log MoM -0.0368 (SD: 0.3132)] and PAPP-A was significantly (p < 0.001) reduced [mean log MoM -0.0133 (SD: 0.2661)] compared to controls [mean log MoM 0.0474 (SD: 0.2521)] in PE pregnancies. There was no correlation between fLI and PAPP-A in control or PE pregnancies. Combined fLI and PAPP-A screening for PE had estimated population detection rates of 22% and 35% for false positives rates of 6% and 12%, respectively. Conclusion: Combining PAPP-A and fLI improves screening performance for PE compared to single marker screening.

AB - Background: Prophylaxis with low-dose aspirin may reduce the risk of pre-eclampsia (PE) if introduced in first trimester. The performance of first trimester maternal serum screening for PE using free leptin index (fLI) and PAPP-A, where fLI = leptin/leptin soluble receptor was studied. Methods: First trimester serum samples from 126 PE pregnancies and 289 control pregnancies were studied. fLI and PAPP-A were converted into gestational age and maternal weight independent log MoM values of PAPP-A and fLI. The screening performance of markers was studied by receiver-operator-characteristics curves. The performance of population screening was estimated by Monte Carlo simulation. Results: fLI was significantly (p < 0.001) elevated [mean log MoM 0.2165 (SD: 0.2604)] compared to controls [mean log MoM -0.0368 (SD: 0.3132)] and PAPP-A was significantly (p < 0.001) reduced [mean log MoM -0.0133 (SD: 0.2661)] compared to controls [mean log MoM 0.0474 (SD: 0.2521)] in PE pregnancies. There was no correlation between fLI and PAPP-A in control or PE pregnancies. Combined fLI and PAPP-A screening for PE had estimated population detection rates of 22% and 35% for false positives rates of 6% and 12%, respectively. Conclusion: Combining PAPP-A and fLI improves screening performance for PE compared to single marker screening.

U2 - 10.1002/pd.2337

DO - 10.1002/pd.2337

M3 - Journal article

C2 - 20013873

SN - 0197-3851

VL - 30

SP - 103

EP - 109

JO - Prenatal Diagnosis

JF - Prenatal Diagnosis

IS - 2

ER -

Free leptin index and PAPP-A: a first trimester maternal serum screening test for pre-eclampsia

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