Formulation technologies to overcome unfavorable properties of peptides and proteins for pulmonary delivery

TY - JOUR

T1 - Formulation technologies to overcome unfavorable properties of peptides and proteins for pulmonary delivery

AU - Wan, Feng

AU - Møller, Eva Horn

AU - Yang, Mingshi

AU - Jørgensen, Lene

PY - 2012

Y1 - 2012

N2 - The pulmonary delivery of peptides and proteins has been considered as a promising alternative administration route to injections. Several advanced formulation technologies have been developed to deliver peptide and protein drugs to and through the lungs by overcoming the unfavorable properties of these macromolecular drugs. Some of them have shown the great potential; however, none of them is flawless. The future innovation in pulmonary delivery for biopharmaceuticals may lie in better understanding of interplay between the lung biology and the advanced formulation technologies.

AB - The pulmonary delivery of peptides and proteins has been considered as a promising alternative administration route to injections. Several advanced formulation technologies have been developed to deliver peptide and protein drugs to and through the lungs by overcoming the unfavorable properties of these macromolecular drugs. Some of them have shown the great potential; however, none of them is flawless. The future innovation in pulmonary delivery for biopharmaceuticals may lie in better understanding of interplay between the lung biology and the advanced formulation technologies.

U2 - 10.1016/j.ddtec.2011.12.003

DO - 10.1016/j.ddtec.2011.12.003

M3 - Journal article

C2 - 24064274

SN - 1740-6749

VL - 9

SP - e141-e146

JO - Drug Discovery Today: Technologies

JF - Drug Discovery Today: Technologies

IS - 2

ER -