Follow-up of extreme neonatal hyperbilirubinaemia in 5- to 10-year-old children: Danish population-based study

TY - JOUR

T1 - Follow-up of extreme neonatal hyperbilirubinaemia in 5- to 10-year-old children

T2 - Danish population-based study

AU - Vandborg, Pernille Kure

AU - Hansen, Bo Mølholm

AU - Greisen, Gorm

AU - Mathiasen, Rene

AU - Kasper, Frederikke

AU - Ebbesen, Finn

N1 - © 2014 Mac Keith Press.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - AIM: To investigate whether infants with neonatal hyperbilirubinaemia but without intermediate or advanced bilirubin encephalopathy develop long-term sequelae, with impairment of motor development, executive function, or hearing.METHOD: This nested double-cohort study included 167 exposed children (107 males, 60 females) born in Denmark 2000 to 2005 at gestational age ≥35 weeks with a total serum bilirubin ≥450 μmol/L (26.3mg/dL) and 163 age-, sex-, and gestational age-matched unexposed children (103 males, 60 females). The children were examined at a mean age of 7.7 years (SD 1.7y) using the Movement Assessment Battery for Children-Second Edition (MABC-2), pure tone audiometry, and the Behavioural Regulation Inventory of Executive Function (BRIEF) questionnaire.RESULTS: The follow-up rate was 70% of the eligible infants in the exposed group and 45% in the unexposed group. Mean difference was -0.2 (95% confidence interval [CI] -1.1 to 0.8) in adjusted standard score for MABC-2 and 0.3 (95% CI -2.9 to 3.5) in adjusted BRIEF executive composite standard score. No children had significant hearing impairment or a diagnosis of cerebral palsy, attention-deficit-hyperactive disorder, or autism spectrum disorder recorded in national registries.INTERPRETATION: No evidence was found of an increased risk of deficits in motor development, executive function, or hearing in children with extreme hyperbilirubinaemia who did not have intermediate or advanced bilirubin encephalopathy.

AB - AIM: To investigate whether infants with neonatal hyperbilirubinaemia but without intermediate or advanced bilirubin encephalopathy develop long-term sequelae, with impairment of motor development, executive function, or hearing.METHOD: This nested double-cohort study included 167 exposed children (107 males, 60 females) born in Denmark 2000 to 2005 at gestational age ≥35 weeks with a total serum bilirubin ≥450 μmol/L (26.3mg/dL) and 163 age-, sex-, and gestational age-matched unexposed children (103 males, 60 females). The children were examined at a mean age of 7.7 years (SD 1.7y) using the Movement Assessment Battery for Children-Second Edition (MABC-2), pure tone audiometry, and the Behavioural Regulation Inventory of Executive Function (BRIEF) questionnaire.RESULTS: The follow-up rate was 70% of the eligible infants in the exposed group and 45% in the unexposed group. Mean difference was -0.2 (95% confidence interval [CI] -1.1 to 0.8) in adjusted standard score for MABC-2 and 0.3 (95% CI -2.9 to 3.5) in adjusted BRIEF executive composite standard score. No children had significant hearing impairment or a diagnosis of cerebral palsy, attention-deficit-hyperactive disorder, or autism spectrum disorder recorded in national registries.INTERPRETATION: No evidence was found of an increased risk of deficits in motor development, executive function, or hearing in children with extreme hyperbilirubinaemia who did not have intermediate or advanced bilirubin encephalopathy.

KW - Child

KW - Child Development

KW - Child, Preschool

KW - Cohort Studies

KW - Denmark

KW - Executive Function

KW - Female

KW - Follow-Up Studies

KW - Hearing

KW - Humans

KW - Hyperbilirubinemia, Neonatal

KW - Male

KW - Registries

U2 - 10.1111/dmcn.12603

DO - 10.1111/dmcn.12603

M3 - Journal article

C2 - 25353277

SN - 0419-0238

VL - 57

SP - 378

EP - 384

JO - Developmental medicine and child neurology. Supplement

JF - Developmental medicine and child neurology. Supplement

IS - 4

ER -