fMRI activation during spike and wave discharges evoked by photic stimulation

Friederike Moeller; Hartwig R Siebner; Nils Ahlgrimm; Stephan Wolff; Hiltrud Muhle; Oliver Granert; Rainer Boor; Olav Jansen; Jean Gotman; Ulrich Stephani; Michael Siniatchkin

doi:10.1016/j.neuroimage.2009.07.019

fMRI activation during spike and wave discharges evoked by photic stimulation

Friederike Moeller, Hartwig R Siebner, Nils Ahlgrimm, Stephan Wolff, Hiltrud Muhle, Oliver Granert, Rainer Boor, Olav Jansen, Jean Gotman, Ulrich Stephani, Michael Siniatchkin

52 Citations (Scopus)

Abstract

Photoparoxysmal response (PPR) is an electroencephalographic (EEG) trait characterized by the occurrence of epileptiform discharges in response to visual stimulation. Studying this trait helps to learn about mechanisms of epileptogenicity. While simultaneous recordings of EEG and functional MRI (EEG-fMRI) in patients with spontaneous generalised spike-wave discharges (GSW) have revealed activation of the thalamus and deactivation in frontoparietal areas, EEG-fMRI studies on evoked GSW such as PPR are lacking. In this EEG-fMRI study, 30 subjects with reported generalised PPR underwent intermittent photic stimulation (IPS) in a 3 T MR scanner. PPR was elicited in 6 subjects, four diagnosed with idiopathic generalised epilepsy and two with tension-type headache. Because PPR is preceded by synchronization of cortical gamma oscillations, blood oxygenation level-dependent (BOLD) signal changes were analysed at the onset of the PPR (standard regressor) and 3 s before the onset of PPR (early regressor) in one model. In all subjects, IPS led to a significant activation of the visual cortex. Based on the early regressor, PPR associated activation was found in the parietal cortex adjacent to the intraparietal sulcus in five and in the premotor cortex in all 6 subjects. The standard regressor revealed deactivation in early activated areas in all subjects and thalamic activation in one subject. In contrast to spontaneous GSW, these results suggest that PPR is a cortical phenomenon with an involvement of the parietal and frontal cortices. Pronounced haemodynamic changes seen with the early regressor could mirror gamma activity that is known to precede PPR.

Original language	English
Journal	NeuroImage
Volume	48
Issue number	4
Pages (from-to)	682-95
Number of pages	13
ISSN	1053-8119
DOIs	https://doi.org/10.1016/j.neuroimage.2009.07.019
Publication status	Published - 2009

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10.1016/j.neuroimage.2009.07.019

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@article{a92ffec0aabd11df928f000ea68e967b,

title = "fMRI activation during spike and wave discharges evoked by photic stimulation",

abstract = "Photoparoxysmal response (PPR) is an electroencephalographic (EEG) trait characterized by the occurrence of epileptiform discharges in response to visual stimulation. Studying this trait helps to learn about mechanisms of epileptogenicity. While simultaneous recordings of EEG and functional MRI (EEG-fMRI) in patients with spontaneous generalised spike-wave discharges (GSW) have revealed activation of the thalamus and deactivation in frontoparietal areas, EEG-fMRI studies on evoked GSW such as PPR are lacking. In this EEG-fMRI study, 30 subjects with reported generalised PPR underwent intermittent photic stimulation (IPS) in a 3 T MR scanner. PPR was elicited in 6 subjects, four diagnosed with idiopathic generalised epilepsy and two with tension-type headache. Because PPR is preceded by synchronization of cortical gamma oscillations, blood oxygenation level-dependent (BOLD) signal changes were analysed at the onset of the PPR (standard regressor) and 3 s before the onset of PPR (early regressor) in one model. In all subjects, IPS led to a significant activation of the visual cortex. Based on the early regressor, PPR associated activation was found in the parietal cortex adjacent to the intraparietal sulcus in five and in the premotor cortex in all 6 subjects. The standard regressor revealed deactivation in early activated areas in all subjects and thalamic activation in one subject. In contrast to spontaneous GSW, these results suggest that PPR is a cortical phenomenon with an involvement of the parietal and frontal cortices. Pronounced haemodynamic changes seen with the early regressor could mirror gamma activity that is known to precede PPR.",

author = "Friederike Moeller and Siebner, {Hartwig R} and Nils Ahlgrimm and Stephan Wolff and Hiltrud Muhle and Oliver Granert and Rainer Boor and Olav Jansen and Jean Gotman and Ulrich Stephani and Michael Siniatchkin",

note = "Keywords: Action Potentials; Adolescent; Brain; Brain Mapping; Cerebrovascular Circulation; Child; Electroencephalography; Epilepsy; Evoked Potentials, Visual; Female; Humans; Magnetic Resonance Imaging; Male; Oxygen; Photic Stimulation; Synaptic Transmission; Tension-Type Headache; Time Factors; Visual Perception; Young Adult",

year = "2009",

doi = "10.1016/j.neuroimage.2009.07.019",

language = "English",

volume = "48",

pages = "682--95",

journal = "NeuroImage",

issn = "1053-8119",

publisher = "Elsevier",

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TY - JOUR

T1 - fMRI activation during spike and wave discharges evoked by photic stimulation

AU - Moeller, Friederike

AU - Siebner, Hartwig R

AU - Ahlgrimm, Nils

AU - Wolff, Stephan

AU - Muhle, Hiltrud

AU - Granert, Oliver

AU - Boor, Rainer

AU - Jansen, Olav

AU - Gotman, Jean

AU - Stephani, Ulrich

AU - Siniatchkin, Michael

N1 - Keywords: Action Potentials; Adolescent; Brain; Brain Mapping; Cerebrovascular Circulation; Child; Electroencephalography; Epilepsy; Evoked Potentials, Visual; Female; Humans; Magnetic Resonance Imaging; Male; Oxygen; Photic Stimulation; Synaptic Transmission; Tension-Type Headache; Time Factors; Visual Perception; Young Adult

PY - 2009

Y1 - 2009

N2 - Photoparoxysmal response (PPR) is an electroencephalographic (EEG) trait characterized by the occurrence of epileptiform discharges in response to visual stimulation. Studying this trait helps to learn about mechanisms of epileptogenicity. While simultaneous recordings of EEG and functional MRI (EEG-fMRI) in patients with spontaneous generalised spike-wave discharges (GSW) have revealed activation of the thalamus and deactivation in frontoparietal areas, EEG-fMRI studies on evoked GSW such as PPR are lacking. In this EEG-fMRI study, 30 subjects with reported generalised PPR underwent intermittent photic stimulation (IPS) in a 3 T MR scanner. PPR was elicited in 6 subjects, four diagnosed with idiopathic generalised epilepsy and two with tension-type headache. Because PPR is preceded by synchronization of cortical gamma oscillations, blood oxygenation level-dependent (BOLD) signal changes were analysed at the onset of the PPR (standard regressor) and 3 s before the onset of PPR (early regressor) in one model. In all subjects, IPS led to a significant activation of the visual cortex. Based on the early regressor, PPR associated activation was found in the parietal cortex adjacent to the intraparietal sulcus in five and in the premotor cortex in all 6 subjects. The standard regressor revealed deactivation in early activated areas in all subjects and thalamic activation in one subject. In contrast to spontaneous GSW, these results suggest that PPR is a cortical phenomenon with an involvement of the parietal and frontal cortices. Pronounced haemodynamic changes seen with the early regressor could mirror gamma activity that is known to precede PPR.

AB - Photoparoxysmal response (PPR) is an electroencephalographic (EEG) trait characterized by the occurrence of epileptiform discharges in response to visual stimulation. Studying this trait helps to learn about mechanisms of epileptogenicity. While simultaneous recordings of EEG and functional MRI (EEG-fMRI) in patients with spontaneous generalised spike-wave discharges (GSW) have revealed activation of the thalamus and deactivation in frontoparietal areas, EEG-fMRI studies on evoked GSW such as PPR are lacking. In this EEG-fMRI study, 30 subjects with reported generalised PPR underwent intermittent photic stimulation (IPS) in a 3 T MR scanner. PPR was elicited in 6 subjects, four diagnosed with idiopathic generalised epilepsy and two with tension-type headache. Because PPR is preceded by synchronization of cortical gamma oscillations, blood oxygenation level-dependent (BOLD) signal changes were analysed at the onset of the PPR (standard regressor) and 3 s before the onset of PPR (early regressor) in one model. In all subjects, IPS led to a significant activation of the visual cortex. Based on the early regressor, PPR associated activation was found in the parietal cortex adjacent to the intraparietal sulcus in five and in the premotor cortex in all 6 subjects. The standard regressor revealed deactivation in early activated areas in all subjects and thalamic activation in one subject. In contrast to spontaneous GSW, these results suggest that PPR is a cortical phenomenon with an involvement of the parietal and frontal cortices. Pronounced haemodynamic changes seen with the early regressor could mirror gamma activity that is known to precede PPR.

U2 - 10.1016/j.neuroimage.2009.07.019

DO - 10.1016/j.neuroimage.2009.07.019

M3 - Journal article

C2 - 19619661

SN - 1053-8119

VL - 48

SP - 682

EP - 695

JO - NeuroImage

JF - NeuroImage

IS - 4

ER -

fMRI activation during spike and wave discharges evoked by photic stimulation

Abstract

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