Fmoc Solid-Phase Peptide Synthesis

Paul Robert Hansen; Alberto Oddo

Fmoc Solid-Phase Peptide Synthesis

33 Citations (Scopus)

Abstract

Synthetic peptides are important as drugs and in research. Currently, the method of choice for producing these compounds is solid-phase peptide synthesis. In this nonspecialist review, we describe the scope and limitations of Fmoc solid-phase peptide synthesis. Furthermore, we provide a detailed protocol for Fmoc peptide synthesis.

Original language	English
Title of host publication	Methods in Molecular Biology: Peptide Antibodies
Number of pages	18
Volume	1348
Publication date	2015
Pages	33-50
Publication status	Published - 2015

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Hansen, P. R., & Oddo, A. (2015). Fmoc Solid-Phase Peptide Synthesis. In Methods in Molecular Biology: Peptide Antibodies (Vol. 1348, pp. 33-50) http://download.springer.com/static/pdf/860/chp%253A10.1007%252F978-1-4939-2999-3_5.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Fprotocol%2F10.1007%2F978-1-4939-2999-3_5&token2=exp=1462881627~acl=%2Fstatic%2Fpdf%2F860%2Fchp%25253A10.1007%25252F978-1-4939-2999-3_5.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Fprotocol%252F10.1007%252F978-1-4939-2999-3_5*~hmac=11b71ec83d47c01148e4da2ce29bb62312999b01c683586bf9dbb58e304886cd

Hansen, PR & Oddo, A 2015, Fmoc Solid-Phase Peptide Synthesis. in Methods in Molecular Biology: Peptide Antibodies. vol. 1348, pp. 33-50. <http://download.springer.com/static/pdf/860/chp%253A10.1007%252F978-1-4939-2999-3_5.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Fprotocol%2F10.1007%2F978-1-4939-2999-3_5&token2=exp=1462881627~acl=%2Fstatic%2Fpdf%2F860%2Fchp%25253A10.1007%25252F978-1-4939-2999-3_5.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Fprotocol%252F10.1007%252F978-1-4939-2999-3_5*~hmac=11b71ec83d47c01148e4da2ce29bb62312999b01c683586bf9dbb58e304886cd>

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AB - Synthetic peptides are important as drugs and in research. Currently, the method of choice for producing these compounds is solid-phase peptide synthesis. In this nonspecialist review, we describe the scope and limitations of Fmoc solid-phase peptide synthesis. Furthermore, we provide a detailed protocol for Fmoc peptide synthesis.

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Fmoc Solid-Phase Peptide Synthesis

Abstract

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