Flux of selected body fluid constituents and benzylpenicillin in polyacrylamide hydrogel (PAAG)

J Brahm; R Lessel; S Ditlev; R Schmidt

doi:10.1002/term.485

Flux of selected body fluid constituents and benzylpenicillin in polyacrylamide hydrogel (PAAG)

J Brahm, R Lessel, S Ditlev, R Schmidt

5 Citations (Scopus)

Abstract

The polyacrylamide hydrogel (PAAG) Aquamid® (Contura International A/S Soeborg, Denmark) is one of the new macromolecules that are used as implants and tissue fillers in reconstruction and aesthetic surgery. This study showed, by means of radioactive isotope methods, that PAAG can exchange both physiological and non-physiological constituents very efficiently with the surrounding medium. The efflux (J, mole/(cm²×s), 25°C, pH 7.2) of water (4.4×10^-5), chloride (2.4×10^-7), urea (1.0×10^-9), and glucose (1.1×10^-9) was 3-40x greater than in human red blood cells. PAAG was also accessible to sucrose, inulin, and benzylpenicillin that could not permeate biological cell membranes. The conclusion of the study is that the hydrogel structure created no significant barrier to the exchange of solvent and solutes with the surrounding medium.

Original language	English
Journal	Journal of Tissue Engineering and Regenerative Medicine
Volume	6
Issue number	10
Pages (from-to)	793-802
Number of pages	10
ISSN	1932-6254
DOIs	https://doi.org/10.1002/term.485
Publication status	Published - Nov 2012

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10.1002/term.485

http://onlinelibrary.wiley.com/doi/10.1002/term.485/abstract

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title = "Flux of selected body fluid constituents and benzylpenicillin in polyacrylamide hydrogel (PAAG)",

abstract = "The polyacrylamide hydrogel (PAAG) Aquamid{\textregistered} (Contura International A/S Soeborg, Denmark) is one of the new macromolecules that are used as implants and tissue fillers in reconstruction and aesthetic surgery. This study showed, by means of radioactive isotope methods, that PAAG can exchange both physiological and non-physiological constituents very efficiently with the surrounding medium. The efflux (J, mole/(cm2×s), 25°C, pH 7.2) of water (4.4×10-5), chloride (2.4×10-7), urea (1.0×10-9), and glucose (1.1×10-9) was 3-40x greater than in human red blood cells. PAAG was also accessible to sucrose, inulin, and benzylpenicillin that could not permeate biological cell membranes. The conclusion of the study is that the hydrogel structure created no significant barrier to the exchange of solvent and solutes with the surrounding medium.",

author = "J Brahm and R Lessel and S Ditlev and R Schmidt",

note = "Copyright {\textcopyright} 2011 John Wiley & Sons, Ltd.",

year = "2012",

month = nov,

doi = "10.1002/term.485",

language = "English",

volume = "6",

pages = "793--802",

journal = "Journal of Tissue Engineering and Regenerative Medicine",

issn = "1932-6254",

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TY - JOUR

T1 - Flux of selected body fluid constituents and benzylpenicillin in polyacrylamide hydrogel (PAAG)

AU - Brahm, J

AU - Lessel, R

AU - Ditlev, S

AU - Schmidt, R

PY - 2012/11

Y1 - 2012/11

N2 - The polyacrylamide hydrogel (PAAG) Aquamid® (Contura International A/S Soeborg, Denmark) is one of the new macromolecules that are used as implants and tissue fillers in reconstruction and aesthetic surgery. This study showed, by means of radioactive isotope methods, that PAAG can exchange both physiological and non-physiological constituents very efficiently with the surrounding medium. The efflux (J, mole/(cm2×s), 25°C, pH 7.2) of water (4.4×10-5), chloride (2.4×10-7), urea (1.0×10-9), and glucose (1.1×10-9) was 3-40x greater than in human red blood cells. PAAG was also accessible to sucrose, inulin, and benzylpenicillin that could not permeate biological cell membranes. The conclusion of the study is that the hydrogel structure created no significant barrier to the exchange of solvent and solutes with the surrounding medium.

AB - The polyacrylamide hydrogel (PAAG) Aquamid® (Contura International A/S Soeborg, Denmark) is one of the new macromolecules that are used as implants and tissue fillers in reconstruction and aesthetic surgery. This study showed, by means of radioactive isotope methods, that PAAG can exchange both physiological and non-physiological constituents very efficiently with the surrounding medium. The efflux (J, mole/(cm2×s), 25°C, pH 7.2) of water (4.4×10-5), chloride (2.4×10-7), urea (1.0×10-9), and glucose (1.1×10-9) was 3-40x greater than in human red blood cells. PAAG was also accessible to sucrose, inulin, and benzylpenicillin that could not permeate biological cell membranes. The conclusion of the study is that the hydrogel structure created no significant barrier to the exchange of solvent and solutes with the surrounding medium.

U2 - 10.1002/term.485

DO - 10.1002/term.485

M3 - Journal article

C2 - 22052857

SN - 1932-6254

VL - 6

SP - 793

EP - 802

JO - Journal of Tissue Engineering and Regenerative Medicine

JF - Journal of Tissue Engineering and Regenerative Medicine

IS - 10

ER -

Flux of selected body fluid constituents and benzylpenicillin in polyacrylamide hydrogel (PAAG)

Abstract

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