Flow-mediated dilatation has no independent prognostic effect in patients with chest pain with or without ischaemic heart disease

Line Skjold Ulriksen; Beata B Malmqvist; Are Hansen; Jens Friberg; Gorm B Jensen

doi:10.1080/00365510902745378

Flow-mediated dilatation has no independent prognostic effect in patients with chest pain with or without ischaemic heart disease

Line Skjold Ulriksen, Beata B Malmqvist, Are Hansen, Jens Friberg, Gorm B Jensen

9 Citations (Scopus)

Abstract

OBJECTIVE: The purpose of this study was to assess the prognostic effect of flow-mediated dilatation (FMD) in patients with chest pain admitted to a coronary care unit. METHODS: Endothelium-dependent FMD in the brachial artery was examined in 223 patients with acute chest pain. All patients underwent a stress test at the time of admittance. On the basis of a positive stress test, a prior myocardial infarction (MI), prior percutaneous coronary intervention (PCI) or coronary bypass surgery (CABG), 137 patients were categorized as having ischaemic heart disease (IHD). RESULTS: Patients with IHD had significantly lower FMD than patients without IHD (p=0.002). During a mean follow-up of 4.2 years, 90 patients had an endpoint event, i.e. cardiovascular death, acute MI, unstable angina pectoris, PCI or CABG. In univariate analysis, FMD <3 % was associated with an increased hazard of the combined endpoint (p=0.04). In multivariate analysis, adjusted for age, gender, IHD and body mass index, no association between FMD and the combined endpoint was found (p=0.99). CONCLUSION: FMD is associated with IHD, but has no independent prognostic effect in patients with chest pain.

Original language	English
Journal	Scandinavian Journal of Clinical & Laboratory Investigation
Volume	69
Issue number	4
Pages (from-to)	475-80
Number of pages	5
ISSN	0036-5513
DOIs	https://doi.org/10.1080/00365510902745378 https://doi.org/10.1080/00365510902745378
Publication status	Published - 2009

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Ulriksen, L. S., Malmqvist, B. B., Hansen, A., Friberg, J., & Jensen, G. B. (2009). Flow-mediated dilatation has no independent prognostic effect in patients with chest pain with or without ischaemic heart disease. Scandinavian Journal of Clinical & Laboratory Investigation, 69(4), 475-80. https://doi.org/10.1080/00365510902745378, https://doi.org/10.1080/00365510902745378

Flow-mediated dilatation has no independent prognostic effect in patients with chest pain with or without ischaemic heart disease. / Ulriksen, Line Skjold; Malmqvist, Beata B; Hansen, Are et al.

In: Scandinavian Journal of Clinical & Laboratory Investigation, Vol. 69, No. 4, 2009, p. 475-80.

Research output: Contribution to journal › Journal article › Research › peer-review

Ulriksen, LS, Malmqvist, BB, Hansen, A, Friberg, J & Jensen, GB 2009, 'Flow-mediated dilatation has no independent prognostic effect in patients with chest pain with or without ischaemic heart disease', Scandinavian Journal of Clinical & Laboratory Investigation, vol. 69, no. 4, pp. 475-80. https://doi.org/10.1080/00365510902745378, https://doi.org/10.1080/00365510902745378

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title = "Flow-mediated dilatation has no independent prognostic effect in patients with chest pain with or without ischaemic heart disease",

abstract = "OBJECTIVE: The purpose of this study was to assess the prognostic effect of flow-mediated dilatation (FMD) in patients with chest pain admitted to a coronary care unit. METHODS: Endothelium-dependent FMD in the brachial artery was examined in 223 patients with acute chest pain. All patients underwent a stress test at the time of admittance. On the basis of a positive stress test, a prior myocardial infarction (MI), prior percutaneous coronary intervention (PCI) or coronary bypass surgery (CABG), 137 patients were categorized as having ischaemic heart disease (IHD). RESULTS: Patients with IHD had significantly lower FMD than patients without IHD (p=0.002). During a mean follow-up of 4.2 years, 90 patients had an endpoint event, i.e. cardiovascular death, acute MI, unstable angina pectoris, PCI or CABG. In univariate analysis, FMD <3 % was associated with an increased hazard of the combined endpoint (p=0.04). In multivariate analysis, adjusted for age, gender, IHD and body mass index, no association between FMD and the combined endpoint was found (p=0.99). CONCLUSION: FMD is associated with IHD, but has no independent prognostic effect in patients with chest pain.",

author = "Ulriksen, {Line Skjold} and Malmqvist, {Beata B} and Are Hansen and Jens Friberg and Jensen, {Gorm B}",

note = "Keywords: Adult; Chest Pain; Dilatation, Pathologic; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Prognosis; Prospective Studies",

year = "2009",

doi = "10.1080/00365510902745378",

language = "English",

volume = "69",

pages = "475--80",

journal = "Scandinavian Journal of Clinical & Laboratory Investigation",

issn = "0036-5513",

publisher = "Taylor & Francis",

number = "4",

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TY - JOUR

T1 - Flow-mediated dilatation has no independent prognostic effect in patients with chest pain with or without ischaemic heart disease

AU - Ulriksen, Line Skjold

AU - Malmqvist, Beata B

AU - Hansen, Are

AU - Friberg, Jens

AU - Jensen, Gorm B

N1 - Keywords: Adult; Chest Pain; Dilatation, Pathologic; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Prognosis; Prospective Studies

PY - 2009

Y1 - 2009

N2 - OBJECTIVE: The purpose of this study was to assess the prognostic effect of flow-mediated dilatation (FMD) in patients with chest pain admitted to a coronary care unit. METHODS: Endothelium-dependent FMD in the brachial artery was examined in 223 patients with acute chest pain. All patients underwent a stress test at the time of admittance. On the basis of a positive stress test, a prior myocardial infarction (MI), prior percutaneous coronary intervention (PCI) or coronary bypass surgery (CABG), 137 patients were categorized as having ischaemic heart disease (IHD). RESULTS: Patients with IHD had significantly lower FMD than patients without IHD (p=0.002). During a mean follow-up of 4.2 years, 90 patients had an endpoint event, i.e. cardiovascular death, acute MI, unstable angina pectoris, PCI or CABG. In univariate analysis, FMD <3 % was associated with an increased hazard of the combined endpoint (p=0.04). In multivariate analysis, adjusted for age, gender, IHD and body mass index, no association between FMD and the combined endpoint was found (p=0.99). CONCLUSION: FMD is associated with IHD, but has no independent prognostic effect in patients with chest pain.

AB - OBJECTIVE: The purpose of this study was to assess the prognostic effect of flow-mediated dilatation (FMD) in patients with chest pain admitted to a coronary care unit. METHODS: Endothelium-dependent FMD in the brachial artery was examined in 223 patients with acute chest pain. All patients underwent a stress test at the time of admittance. On the basis of a positive stress test, a prior myocardial infarction (MI), prior percutaneous coronary intervention (PCI) or coronary bypass surgery (CABG), 137 patients were categorized as having ischaemic heart disease (IHD). RESULTS: Patients with IHD had significantly lower FMD than patients without IHD (p=0.002). During a mean follow-up of 4.2 years, 90 patients had an endpoint event, i.e. cardiovascular death, acute MI, unstable angina pectoris, PCI or CABG. In univariate analysis, FMD <3 % was associated with an increased hazard of the combined endpoint (p=0.04). In multivariate analysis, adjusted for age, gender, IHD and body mass index, no association between FMD and the combined endpoint was found (p=0.99). CONCLUSION: FMD is associated with IHD, but has no independent prognostic effect in patients with chest pain.

U2 - 10.1080/00365510902745378

DO - 10.1080/00365510902745378

M3 - Journal article

C2 - 19347749

SN - 0036-5513

VL - 69

SP - 475

EP - 480

JO - Scandinavian Journal of Clinical & Laboratory Investigation

JF - Scandinavian Journal of Clinical & Laboratory Investigation

IS - 4

ER -

Flow-mediated dilatation has no independent prognostic effect in patients with chest pain with or without ischaemic heart disease

Abstract

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