Five-year results from a prospective multicentre study of percutaneous pulmonary valve implantation demonstrate sustained removal of significant pulmonary regurgitation, improved right ventricular outflow tract obstruction and improved quality of life

Alfred Hager; Stephan Schubert; Peter Ewert; Lars Søndergaard; Maarten Witsenburg; Paolo Guccione; Lee N Benson; José Suárez de Lezo; Te-Hsin Lung; John Hess; Andreas Eicken; Felix Berger

Five-year results from a prospective multicentre study of percutaneous pulmonary valve implantation demonstrate sustained removal of significant pulmonary regurgitation, improved right ventricular outflow tract obstruction and improved quality of life

Alfred Hager, Stephan Schubert, Peter Ewert, Lars Søndergaard, Maarten Witsenburg, Paolo Guccione, Lee N Benson, José Suárez de Lezo, Te-Hsin Lung, John Hess, Andreas Eicken, Felix Berger

Department of Clinical Medicine

12 Citations (Scopus)

Abstract

AIMS: Percutaneous pulmonary valve implantation (PPVI) is used to treat patients with dysfunctional pulmonary valve conduits. Short- and longer-term results from multiple trials have outlined haemodynamic improvements. Our aim was to report the long-term results, including quality of life, from a multicentre trial in Europe and Canada.

METHODS AND RESULTS: From October 2007 to April 2009, 71 patients (24 female; median age 19.0 [IQR: 14.0 to 25.0] years) were enrolled in a prospective cohort study. PPVI was performed successfully in 63 patients. At five-year follow-up four patients had died. Moderate and severe pulmonary regurgitation were completely resolved in all except one patient, who needed re-PPVI. Outflow tract obstruction improved significantly from a mean pressure gradient of 37.7±12.1 mmHg before PPVI to 17.3±9.7 mmHg at five-year follow-up; however, 11 patients needed treatment for restenosis. The EQ-5D quality of life utility index and visual analogue scale scores were both significantly improved six months post PPVI and remained so at five years.

CONCLUSIONS: Five-year results following PPVI demonstrate resolved moderate or severe pulmonary regurgitation, improved right ventricular outflow tract obstruction, and improved quality of life.

Original language	English
Journal	EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Volume	12
Issue number	14
Pages (from-to)	1715-1723
Number of pages	9
ISSN	1774-024X
Publication status	Published - 20 Feb 2017

Keywords

Adolescent
Adult
Cardiac Catheterization/methods
Female
Heart Valve Prosthesis
Hemodynamics/physiology
Humans
Male
Middle Aged
Prospective Studies
Pulmonary Valve Insufficiency/physiopathology
Pulmonary Valve Stenosis/physiopathology
Quality of Life
Treatment Outcome
Ventricular Function, Right/physiology
Ventricular Outflow Obstruction/physiopathology
Young Adult

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https://www.pcronline.com/eurointervention/111th_issue/volume-12/number-14/281/five-year-results-from-a-prospective-multicentre-study-of-percutaneous-pulmonary-valve-implantation-demonstrate-sustained-removal-of-significant-pulmonary-regurgitation-improved-right-ventricular-outflow-tract-obstruction-and-improved-quality-of-life.html

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Hager, A., Schubert, S., Ewert, P., Søndergaard, L., Witsenburg, M., Guccione, P., Benson, L. N., Suárez de Lezo, J., Lung, T-H., Hess, J., Eicken, A., & Berger, F. (2017). Five-year results from a prospective multicentre study of percutaneous pulmonary valve implantation demonstrate sustained removal of significant pulmonary regurgitation, improved right ventricular outflow tract obstruction and improved quality of life. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 12(14), 1715-1723. https://www.pcronline.com/eurointervention/111th_issue/volume-12/number-14/281/five-year-results-from-a-prospective-multicentre-study-of-percutaneous-pulmonary-valve-implantation-demonstrate-sustained-removal-of-significant-pulmonary-regurgitation-improved-right-ventricular-outflow-tract-obstruction-and-improved-quality-of-life.html

Five-year results from a prospective multicentre study of percutaneous pulmonary valve implantation demonstrate sustained removal of significant pulmonary regurgitation, improved right ventricular outflow tract obstruction and improved quality of life. / Hager, Alfred; Schubert, Stephan; Ewert, Peter et al.

In: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Vol. 12, No. 14, 20.02.2017, p. 1715-1723.

Research output: Contribution to journal › Journal article › Research › peer-review

Hager, A, Schubert, S, Ewert, P, Søndergaard, L, Witsenburg, M, Guccione, P, Benson, LN, Suárez de Lezo, J, Lung, T-H, Hess, J, Eicken, A & Berger, F 2017, 'Five-year results from a prospective multicentre study of percutaneous pulmonary valve implantation demonstrate sustained removal of significant pulmonary regurgitation, improved right ventricular outflow tract obstruction and improved quality of life', EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, vol. 12, no. 14, pp. 1715-1723. <https://www.pcronline.com/eurointervention/111th_issue/volume-12/number-14/281/five-year-results-from-a-prospective-multicentre-study-of-percutaneous-pulmonary-valve-implantation-demonstrate-sustained-removal-of-significant-pulmonary-regurgitation-improved-right-ventricular-outflow-tract-obstruction-and-improved-quality-of-life.html>

Hager A, Schubert S, Ewert P, Søndergaard L, Witsenburg M, Guccione P et al. Five-year results from a prospective multicentre study of percutaneous pulmonary valve implantation demonstrate sustained removal of significant pulmonary regurgitation, improved right ventricular outflow tract obstruction and improved quality of life. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology. 2017 Feb 20;12(14):1715-1723.

Hager, Alfred ; Schubert, Stephan ; Ewert, Peter et al. / Five-year results from a prospective multicentre study of percutaneous pulmonary valve implantation demonstrate sustained removal of significant pulmonary regurgitation, improved right ventricular outflow tract obstruction and improved quality of life. In: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology. 2017 ; Vol. 12, No. 14. pp. 1715-1723.

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abstract = "AIMS: Percutaneous pulmonary valve implantation (PPVI) is used to treat patients with dysfunctional pulmonary valve conduits. Short- and longer-term results from multiple trials have outlined haemodynamic improvements. Our aim was to report the long-term results, including quality of life, from a multicentre trial in Europe and Canada.METHODS AND RESULTS: From October 2007 to April 2009, 71 patients (24 female; median age 19.0 [IQR: 14.0 to 25.0] years) were enrolled in a prospective cohort study. PPVI was performed successfully in 63 patients. At five-year follow-up four patients had died. Moderate and severe pulmonary regurgitation were completely resolved in all except one patient, who needed re-PPVI. Outflow tract obstruction improved significantly from a mean pressure gradient of 37.7±12.1 mmHg before PPVI to 17.3±9.7 mmHg at five-year follow-up; however, 11 patients needed treatment for restenosis. The EQ-5D quality of life utility index and visual analogue scale scores were both significantly improved six months post PPVI and remained so at five years.CONCLUSIONS: Five-year results following PPVI demonstrate resolved moderate or severe pulmonary regurgitation, improved right ventricular outflow tract obstruction, and improved quality of life.",

keywords = "Adolescent, Adult, Cardiac Catheterization/methods, Female, Heart Valve Prosthesis, Hemodynamics/physiology, Humans, Male, Middle Aged, Prospective Studies, Pulmonary Valve Insufficiency/physiopathology, Pulmonary Valve Stenosis/physiopathology, Quality of Life, Treatment Outcome, Ventricular Function, Right/physiology, Ventricular Outflow Obstruction/physiopathology, Young Adult",

author = "Alfred Hager and Stephan Schubert and Peter Ewert and Lars S{\o}ndergaard and Maarten Witsenburg and Paolo Guccione and Benson, {Lee N} and {Su{\'a}rez de Lezo}, Jos{\'e} and Te-Hsin Lung and John Hess and Andreas Eicken and Felix Berger",

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T1 - Five-year results from a prospective multicentre study of percutaneous pulmonary valve implantation demonstrate sustained removal of significant pulmonary regurgitation, improved right ventricular outflow tract obstruction and improved quality of life

AU - Hager, Alfred

AU - Schubert, Stephan

AU - Ewert, Peter

AU - Søndergaard, Lars

AU - Witsenburg, Maarten

AU - Guccione, Paolo

AU - Benson, Lee N

AU - Suárez de Lezo, José

AU - Lung, Te-Hsin

AU - Hess, John

AU - Eicken, Andreas

AU - Berger, Felix

PY - 2017/2/20

Y1 - 2017/2/20

N2 - AIMS: Percutaneous pulmonary valve implantation (PPVI) is used to treat patients with dysfunctional pulmonary valve conduits. Short- and longer-term results from multiple trials have outlined haemodynamic improvements. Our aim was to report the long-term results, including quality of life, from a multicentre trial in Europe and Canada.METHODS AND RESULTS: From October 2007 to April 2009, 71 patients (24 female; median age 19.0 [IQR: 14.0 to 25.0] years) were enrolled in a prospective cohort study. PPVI was performed successfully in 63 patients. At five-year follow-up four patients had died. Moderate and severe pulmonary regurgitation were completely resolved in all except one patient, who needed re-PPVI. Outflow tract obstruction improved significantly from a mean pressure gradient of 37.7±12.1 mmHg before PPVI to 17.3±9.7 mmHg at five-year follow-up; however, 11 patients needed treatment for restenosis. The EQ-5D quality of life utility index and visual analogue scale scores were both significantly improved six months post PPVI and remained so at five years.CONCLUSIONS: Five-year results following PPVI demonstrate resolved moderate or severe pulmonary regurgitation, improved right ventricular outflow tract obstruction, and improved quality of life.

AB - AIMS: Percutaneous pulmonary valve implantation (PPVI) is used to treat patients with dysfunctional pulmonary valve conduits. Short- and longer-term results from multiple trials have outlined haemodynamic improvements. Our aim was to report the long-term results, including quality of life, from a multicentre trial in Europe and Canada.METHODS AND RESULTS: From October 2007 to April 2009, 71 patients (24 female; median age 19.0 [IQR: 14.0 to 25.0] years) were enrolled in a prospective cohort study. PPVI was performed successfully in 63 patients. At five-year follow-up four patients had died. Moderate and severe pulmonary regurgitation were completely resolved in all except one patient, who needed re-PPVI. Outflow tract obstruction improved significantly from a mean pressure gradient of 37.7±12.1 mmHg before PPVI to 17.3±9.7 mmHg at five-year follow-up; however, 11 patients needed treatment for restenosis. The EQ-5D quality of life utility index and visual analogue scale scores were both significantly improved six months post PPVI and remained so at five years.CONCLUSIONS: Five-year results following PPVI demonstrate resolved moderate or severe pulmonary regurgitation, improved right ventricular outflow tract obstruction, and improved quality of life.

KW - Adolescent

KW - Adult

KW - Cardiac Catheterization/methods

KW - Female

KW - Heart Valve Prosthesis

KW - Hemodynamics/physiology

KW - Humans

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Pulmonary Valve Insufficiency/physiopathology

KW - Pulmonary Valve Stenosis/physiopathology

KW - Quality of Life

KW - Treatment Outcome

KW - Ventricular Function, Right/physiology

KW - Ventricular Outflow Obstruction/physiopathology

KW - Young Adult

M3 - Journal article

C2 - 28216473

SN - 1774-024X

VL - 12

SP - 1715

EP - 1723

JO - EuroIntervention

JF - EuroIntervention

IS - 14

ER -