Five-year change in physical activity is associated with changes in cardiovascular disease risk factors: the Inter99 study

TY - JOUR

T1 - Five-year change in physical activity is associated with changes in cardiovascular disease risk factors: the Inter99 study

AU - Aadahl, Mette

AU - von Huth Smith, L

AU - Pisinger, Charlotte

AU - Toft, Ulla Marie Nørgaard

AU - Glümer, C

AU - Borch-Johnsen, K

AU - Jørgensen, Torben

N1 - DA - 20100610 IS - 1096-0260 (Electronic) IS - 0091-7435 (Linking) LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't SB - IM

PY - 2009

Y1 - 2009

N2 - OBJECTIVE: To evaluate whether five-year changes in self-reported physical activity level were associated with changes in waist circumference, weight, serum lipids and blood pressure. METHODS: In the Inter99 study (1999-2006) in Copenhagen, Denmark, 4039 men and women (30-60 years) answered questions on lifestyle and provided blood samples and anthropometric measures at baseline and after five years. Multiple regression analyses were performed with five-year value of each cardiovascular biomarker as outcome and change in physical activity level as explanatory variable. RESULTS: Approximately 50% of the study population were men (n=2023). Change in physical activity level was inversely associated with change in weight (p<0.0001), waist (p<0.0001), diastolic blood pressure (p=0.04), total cholesterol (p=0.006), LDL (p=0.007), triglycerides (p=0.02) and with a composite risk score "the Copenhagen risk score" (p<0.0001), and positively associated with HDL in men (p=0.01). CONCLUSION: Five-year changes in physical activity level were significantly associated with relevant changes in weight, waist circumference, diastolic BP and serum lipids in a population-based cohort of adult men and women. Change in physical activity level induced a significant change in HDL concentration in men only. Women's use of hormone replacement therapy may partly explain this gender difference.

AB - OBJECTIVE: To evaluate whether five-year changes in self-reported physical activity level were associated with changes in waist circumference, weight, serum lipids and blood pressure. METHODS: In the Inter99 study (1999-2006) in Copenhagen, Denmark, 4039 men and women (30-60 years) answered questions on lifestyle and provided blood samples and anthropometric measures at baseline and after five years. Multiple regression analyses were performed with five-year value of each cardiovascular biomarker as outcome and change in physical activity level as explanatory variable. RESULTS: Approximately 50% of the study population were men (n=2023). Change in physical activity level was inversely associated with change in weight (p<0.0001), waist (p<0.0001), diastolic blood pressure (p=0.04), total cholesterol (p=0.006), LDL (p=0.007), triglycerides (p=0.02) and with a composite risk score "the Copenhagen risk score" (p<0.0001), and positively associated with HDL in men (p=0.01). CONCLUSION: Five-year changes in physical activity level were significantly associated with relevant changes in weight, waist circumference, diastolic BP and serum lipids in a population-based cohort of adult men and women. Change in physical activity level induced a significant change in HDL concentration in men only. Women's use of hormone replacement therapy may partly explain this gender difference.

U2 - 10.1016/j.ypmed.2009.01.015

DO - 10.1016/j.ypmed.2009.01.015

M3 - Journal article

C2 - 19463487

SN - 0091-7435

VL - 48

SP - 326

EP - 331

JO - Preventive Medicine

JF - Preventive Medicine

IS - 4

ER -