Abstract
OBJECTIVE: To establish the relationship between the first-trimester screening markers [pregnancy-associated plasma protein A (PAPP-A), free human chorionic gonadotrophin-beta (beta-hCG), nuchal translucency (NT)], the Down syndrome (DS) risk estimate, and the adverse outcomes such as low birth weight, small for gestational age (SGA) and pre-term delivery.
METHODS: A retrospective cohort study including 1,734 non-selected singleton pregnancies consecutively enrolled into the programme of first-trimester combined screening for DS in a 12-month period at a single centre. Data from the Prenatal Patient Registry in ASTRAIA were combined with the Danish National Newborn Screening Registry and Danish Birth Registry.
RESULTS: There was a significant relation between low PAPP-A MoM, low beta-hCG MoM, increased risk estimate for DS and low birth weight and SGA. Low PAPP-A MoM and increased NT showed a significant relation to pre-term and spontaneous pre-term delivery. Low PAPP-A MoM showed a significant relation to early pre-term delivery.
CONCLUSION: First-trimester screening markers exhibited a significant relation to low birth weight, SGA and to some extent, to pre-term and early pre-term delivery. The screening performance of individual markers was poor.
| Original language | English |
|---|---|
| Journal | Prenatal Diagnosis |
| Volume | 28 |
| Issue number | 3 |
| Pages (from-to) | 247-53 |
| Number of pages | 7 |
| ISSN | 0197-3851 |
| DOIs | |
| Publication status | Published - Mar 2008 |
Keywords
- Adult
- Chorionic Gonadotropin, beta Subunit, Human
- Cohort Studies
- Down Syndrome
- Female
- Gestational Age
- Humans
- Infant, Low Birth Weight
- Infant, Newborn
- Mass Screening
- Nuchal Translucency Measurement
- Obstetric Labor, Premature
- Predictive Value of Tests
- Pregnancy
- Pregnancy Trimester, First
- Pregnancy-Associated Plasma Protein-A
- Retrospective Studies
- Journal Article
- Research Support, Non-U.S. Gov't