First Danish single-institution experience with radical prostatectomy: impact of surgical margins on biochemical outcome

Marie-Louise Vrang; Martin Andreas Røder; Ben Vainer; Ib Jarle Christensen; Lisa Gruschy; Klaus Brasso; Peter Iversen

doi:10.3109/00365599.2011.644860

First Danish single-institution experience with radical prostatectomy: impact of surgical margins on biochemical outcome

Marie-Louise Vrang, Martin Andreas Røder, Ben Vainer, Ib Jarle Christensen, Lisa Gruschy, Klaus Brasso, Peter Iversen

6 Citations (Scopus)

Abstract

Objective.This study aimed to investigate the impact of positive surgical margins (PSMs), stratified by location and extension, on biochemical outcome after radical retropubic prostatectomy (RRP). Material and methods. The study included data from 605 consecutive patients treated with RRP for localized prostate cancer. Patients with node-positive disease were excluded. Biochemical recurrence-free survival was calculated using the KaplanMeier method. Univariate and multivariate analysis was used to assess risk factors. Results.The overall PSM rate was 35.4%. Eighty-three per cent (82.7%) of these had a single PSM, whereas 17.3% of patients had two or more PSMs. Apical PSMs were present in 42.5% and non-apical in 57.5%. The presence of any PSM had a significant impact on the risk of biochemical recurrence (BR) [hazard ratio (HR) 3.3, p < 0.0001]. Compared with margin-negative patients, both apical and non-apical PSMs increased the risk of BR (HR 2.1 and 4.2, p 0.02 and p < 0.0001, respectively). The number of PSMs also influenced the risk of BR (one PSM: HR 2.8, p < 0.0001, vs two or more PSMs: HR 5.5, p < 0.0001). In multivariate analysis, pT category, PSA and prostatectomy Gleason score independently increased the risk of BR. In an exploratory multivariate analysis of pT2 tumours, the impact of apical PSMs on biochemical recurrence-free survival (BRFS) was not statistically significant, although with an HR of 2.1. Non-apical PSM was associated with a significantly increased risk of BR (HR 3.4, p 0.01). Number of PSMs did not influence the risk of BR in multivariate analysis. Conclusion. The presence of PSMs after RRP is associated with a higher risk of BR. Multiple and non-apical PSMs are associated with a significantly higher risk of BR compared to single and apical PSMs.

Original language	English
Journal	Scandinavian Journal of Urology and Nephrology
Volume	46
Issue number	3
Pages (from-to)	172-9
Number of pages	8
DOIs	https://doi.org/10.3109/00365599.2011.644860
Publication status	Published - Jun 2012

Keywords

Aged
Denmark
Disease-Free Survival
Humans
Male
Middle Aged
Neoplasm, Residual
Prospective Studies
Prostate-Specific Antigen
Prostatectomy
Prostatic Neoplasms
Treatment Outcome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/00365599.2011.644860

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@article{60cf8dfd0b8b40688d3d17973af177a6,

title = "First Danish single-institution experience with radical prostatectomy: impact of surgical margins on biochemical outcome",

abstract = "Objective.This study aimed to investigate the impact of positive surgical margins (PSMs), stratified by location and extension, on biochemical outcome after radical retropubic prostatectomy (RRP). Material and methods. The study included data from 605 consecutive patients treated with RRP for localized prostate cancer. Patients with node-positive disease were excluded. Biochemical recurrence-free survival was calculated using the KaplanMeier method. Univariate and multivariate analysis was used to assess risk factors. Results.The overall PSM rate was 35.4%. Eighty-three per cent (82.7%) of these had a single PSM, whereas 17.3% of patients had two or more PSMs. Apical PSMs were present in 42.5% and non-apical in 57.5%. The presence of any PSM had a significant impact on the risk of biochemical recurrence (BR) [hazard ratio (HR) 3.3, p < 0.0001]. Compared with margin-negative patients, both apical and non-apical PSMs increased the risk of BR (HR 2.1 and 4.2, p 0.02 and p < 0.0001, respectively). The number of PSMs also influenced the risk of BR (one PSM: HR 2.8, p < 0.0001, vs two or more PSMs: HR 5.5, p < 0.0001). In multivariate analysis, pT category, PSA and prostatectomy Gleason score independently increased the risk of BR. In an exploratory multivariate analysis of pT2 tumours, the impact of apical PSMs on biochemical recurrence-free survival (BRFS) was not statistically significant, although with an HR of 2.1. Non-apical PSM was associated with a significantly increased risk of BR (HR 3.4, p 0.01). Number of PSMs did not influence the risk of BR in multivariate analysis. Conclusion. The presence of PSMs after RRP is associated with a higher risk of BR. Multiple and non-apical PSMs are associated with a significantly higher risk of BR compared to single and apical PSMs.",

keywords = "Aged, Denmark, Disease-Free Survival, Humans, Male, Middle Aged, Neoplasm, Residual, Prospective Studies, Prostate-Specific Antigen, Prostatectomy, Prostatic Neoplasms, Treatment Outcome",

author = "Marie-Louise Vrang and R{\o}der, {Martin Andreas} and Ben Vainer and Christensen, {Ib Jarle} and Lisa Gruschy and Klaus Brasso and Peter Iversen",

year = "2012",

month = jun,

doi = "10.3109/00365599.2011.644860",

language = "English",

volume = "46",

pages = "172--9",

journal = "Scandinavian Journal of Urology and Nephrology",

issn = "0036-5599",

publisher = "Taylor & Francis",

number = "3",

}

TY - JOUR

T1 - First Danish single-institution experience with radical prostatectomy

T2 - impact of surgical margins on biochemical outcome

AU - Vrang, Marie-Louise

AU - Røder, Martin Andreas

AU - Vainer, Ben

AU - Christensen, Ib Jarle

AU - Gruschy, Lisa

AU - Brasso, Klaus

AU - Iversen, Peter

PY - 2012/6

Y1 - 2012/6

N2 - Objective.This study aimed to investigate the impact of positive surgical margins (PSMs), stratified by location and extension, on biochemical outcome after radical retropubic prostatectomy (RRP). Material and methods. The study included data from 605 consecutive patients treated with RRP for localized prostate cancer. Patients with node-positive disease were excluded. Biochemical recurrence-free survival was calculated using the KaplanMeier method. Univariate and multivariate analysis was used to assess risk factors. Results.The overall PSM rate was 35.4%. Eighty-three per cent (82.7%) of these had a single PSM, whereas 17.3% of patients had two or more PSMs. Apical PSMs were present in 42.5% and non-apical in 57.5%. The presence of any PSM had a significant impact on the risk of biochemical recurrence (BR) [hazard ratio (HR) 3.3, p < 0.0001]. Compared with margin-negative patients, both apical and non-apical PSMs increased the risk of BR (HR 2.1 and 4.2, p 0.02 and p < 0.0001, respectively). The number of PSMs also influenced the risk of BR (one PSM: HR 2.8, p < 0.0001, vs two or more PSMs: HR 5.5, p < 0.0001). In multivariate analysis, pT category, PSA and prostatectomy Gleason score independently increased the risk of BR. In an exploratory multivariate analysis of pT2 tumours, the impact of apical PSMs on biochemical recurrence-free survival (BRFS) was not statistically significant, although with an HR of 2.1. Non-apical PSM was associated with a significantly increased risk of BR (HR 3.4, p 0.01). Number of PSMs did not influence the risk of BR in multivariate analysis. Conclusion. The presence of PSMs after RRP is associated with a higher risk of BR. Multiple and non-apical PSMs are associated with a significantly higher risk of BR compared to single and apical PSMs.

AB - Objective.This study aimed to investigate the impact of positive surgical margins (PSMs), stratified by location and extension, on biochemical outcome after radical retropubic prostatectomy (RRP). Material and methods. The study included data from 605 consecutive patients treated with RRP for localized prostate cancer. Patients with node-positive disease were excluded. Biochemical recurrence-free survival was calculated using the KaplanMeier method. Univariate and multivariate analysis was used to assess risk factors. Results.The overall PSM rate was 35.4%. Eighty-three per cent (82.7%) of these had a single PSM, whereas 17.3% of patients had two or more PSMs. Apical PSMs were present in 42.5% and non-apical in 57.5%. The presence of any PSM had a significant impact on the risk of biochemical recurrence (BR) [hazard ratio (HR) 3.3, p < 0.0001]. Compared with margin-negative patients, both apical and non-apical PSMs increased the risk of BR (HR 2.1 and 4.2, p 0.02 and p < 0.0001, respectively). The number of PSMs also influenced the risk of BR (one PSM: HR 2.8, p < 0.0001, vs two or more PSMs: HR 5.5, p < 0.0001). In multivariate analysis, pT category, PSA and prostatectomy Gleason score independently increased the risk of BR. In an exploratory multivariate analysis of pT2 tumours, the impact of apical PSMs on biochemical recurrence-free survival (BRFS) was not statistically significant, although with an HR of 2.1. Non-apical PSM was associated with a significantly increased risk of BR (HR 3.4, p 0.01). Number of PSMs did not influence the risk of BR in multivariate analysis. Conclusion. The presence of PSMs after RRP is associated with a higher risk of BR. Multiple and non-apical PSMs are associated with a significantly higher risk of BR compared to single and apical PSMs.

KW - Aged

KW - Denmark

KW - Disease-Free Survival

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasm, Residual

KW - Prospective Studies

KW - Prostate-Specific Antigen

KW - Prostatectomy

KW - Prostatic Neoplasms

KW - Treatment Outcome

U2 - 10.3109/00365599.2011.644860

DO - 10.3109/00365599.2011.644860

M3 - Journal article

C2 - 22320899

SN - 0036-5599

VL - 46

SP - 172

EP - 179

JO - Scandinavian Journal of Urology and Nephrology

JF - Scandinavian Journal of Urology and Nephrology

IS - 3

ER -

First Danish single-institution experience with radical prostatectomy: impact of surgical margins on biochemical outcome

Abstract

Keywords

UN SDGs

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