Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)

Hatef Darabi; Jonathan Beesley; Arnaud Droit; Siddhartha Kar; Silje Nord; Mahdi Moradi Marjaneh; Penny Soucy; Kyriaki Michailidou; Maya Ghoussaini; Hanna Fues Wahl; Manjeet K Bolla; Qin Wang; Joe Dennis; M Rosario Alonso; Irene L Andrulis; Hoda Anton-Culver; Volker Arndt; Matthias W Beckmann; Javier Benitez; Natalia V Bogdanova; Stig E Bojesen; Hiltrud Brauch; Hermann Brenner; Annegien Broeks; Thomas Brüning; Barbara Burwinkel; Jenny Chang-Claude; Ji-Yeob Choi; Don M Conroy; Fergus J Couch; Angela Cox; Simon S Cross; Kamila Czene; Peter Devilee; Thilo Dörk; Douglas F Easton; Peter A Fasching; Jonine Figueroa; Olivia Fletcher; Henrik Flyger; Eva Galle; Montserrat García-Closas; Graham G Giles; Mark S Goldberg; Anna González-Neira; Pascal Guénel; Christopher A Haiman; Emily Hallberg; Ute Hamann; Mikael Hartman; Antoinette Hollestelle; John L Hopper; Hidemi Ito; Anna Jakubowska; Nichola Johnson; Daehee Kang; Sofia Khan; Veli-Matti Kosma; Mieke Kriege; Vessela Kristensen; Diether Lambrechts; Loic Le Marchand; Soo Chin Lee; Annika Lindblom; Artitaya Lophatananon; Jan Lubinski; Arto Mannermaa; Siranoush Manoukian; Sara Margolin; Keitaro Matsuo; Rebecca Mayes; James McKay; Alfons Meindl; Roger L Milne; Kenneth Muir; Susan L Neuhausen; Heli Nevanlinna; Curtis Olswold; Nick Orr; Paolo Peterlongo; Guillermo Pita; Katri Pylkäs; Anja Rudolph; Suleeporn Sangrajrang; Elinor J Sawyer; Marjanka K Schmidt; Rita K Schmutzler; Caroline Seynaeve; Mitul Shah; Chen-Yang Shen; Xiao-Ou Shu; Melissa C Southey; Daniel O Stram; Harald Surowy; Anthony Swerdlow; Soo H Teo; Daniel C Tessier; Ian Tomlinson; Diana Torres; Thérèse Truong; Celine M Vachon; Daniel Vincent; Robert Winqvist; Anna H Wu; Pei-Ei Wu; Cheng Har Yip; Wei Zheng; Paul D P Pharoah; Per Hall; Stacey L Edwards; Jacques Simard; Juliet D French; Georgia Chenevix-Trench; Alison M Dunning

doi:10.1038/srep32512

Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)

Hatef Darabi, Jonathan Beesley, Arnaud Droit, Siddhartha Kar, Silje Nord, Mahdi Moradi Marjaneh, Penny Soucy, Kyriaki Michailidou, Maya Ghoussaini, Hanna Fues Wahl, Manjeet K Bolla, Qin Wang, Joe Dennis, M Rosario Alonso, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Matthias W Beckmann, Javier Benitez, Natalia V BogdanovaStig E Bojesen, Hiltrud Brauch, Hermann Brenner, Annegien Broeks, Thomas Brüning, Barbara Burwinkel, Jenny Chang-Claude, Ji-Yeob Choi, Don M Conroy, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Peter Devilee, Thilo Dörk, Douglas F Easton, Peter A Fasching, Jonine Figueroa, Olivia Fletcher, Henrik Flyger, Eva Galle, Montserrat García-Closas, Graham G Giles, Mark S Goldberg, Anna González-Neira, Pascal Guénel, Christopher A Haiman, Emily Hallberg, Ute Hamann, Mikael Hartman, Antoinette Hollestelle, John L Hopper, Hidemi Ito, Anna Jakubowska, Nichola Johnson, Daehee Kang, Sofia Khan, Veli-Matti Kosma, Mieke Kriege, Vessela Kristensen, Diether Lambrechts, Loic Le Marchand, Soo Chin Lee, Annika Lindblom, Artitaya Lophatananon, Jan Lubinski, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, Keitaro Matsuo, Rebecca Mayes, James McKay, Alfons Meindl, Roger L Milne, Kenneth Muir, Susan L Neuhausen, Heli Nevanlinna, Curtis Olswold, Nick Orr, Paolo Peterlongo, Guillermo Pita, Katri Pylkäs, Anja Rudolph, Suleeporn Sangrajrang, Elinor J Sawyer, Marjanka K Schmidt, Rita K Schmutzler, Caroline Seynaeve, Mitul Shah, Chen-Yang Shen, Xiao-Ou Shu, Melissa C Southey, Daniel O Stram, Harald Surowy, Anthony Swerdlow, Soo H Teo, Daniel C Tessier, Ian Tomlinson, Diana Torres, Thérèse Truong, Celine M Vachon, Daniel Vincent, Robert Winqvist, Anna H Wu, Pei-Ei Wu, Cheng Har Yip, Wei Zheng, Paul D P Pharoah, Per Hall, Stacey L Edwards, Jacques Simard, Juliet D French, Georgia Chenevix-Trench, Alison M Dunning

Department of Clinical Medicine

13 Citations (Scopus)

Abstract

Genome-wide association studies have found SNPs at 17q22 to be associated with breast cancer risk. To identify potential causal variants related to breast cancer risk, we performed a high resolution fine-mapping analysis that involved genotyping 517 SNPs using a custom Illumina iSelect array (iCOGS) followed by imputation of genotypes for 3,134 SNPs in more than 89,000 participants of European ancestry from the Breast Cancer Association Consortium (BCAC). We identified 28 highly correlated common variants, in a 53 Kb region spanning two introns of the STXBP4 gene, that are strong candidates for driving breast cancer risk (lead SNP rs2787486 (OR = 0.92; CI 0.90-0.94; P = 8.96 × 10(-15))) and are correlated with two previously reported risk-associated variants at this locus, SNPs rs6504950 (OR = 0.94, P = 2.04 × 10(-09), r(2) = 0.73 with lead SNP) and rs1156287 (OR = 0.93, P = 3.41 × 10(-11), r(2) = 0.83 with lead SNP). Analyses indicate only one causal SNP in the region and several enhancer elements targeting STXBP4 are located within the 53 kb association signal. Expression studies in breast tumor tissues found SNP rs2787486 to be associated with increased STXBP4 expression, suggesting this may be a target gene of this locus.

Original language	English
Article number	32512
Journal	Scientific Reports
Volume	6
Pages (from-to)	1-14
Number of pages	14
ISSN	2045-2322
DOIs	https://doi.org/10.1038/srep32512
Publication status	Published - 7 Sept 2016

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/srep32512

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Darabi, H., Beesley, J., Droit, A., Kar, S., Nord, S., Moradi Marjaneh, M., Soucy, P., Michailidou, K., Ghoussaini, M., Fues Wahl, H., Bolla, M. K., Wang, Q., Dennis, J., Alonso, M. R., Andrulis, I. L., Anton-Culver, H., Arndt, V., Beckmann, M. W., Benitez, J., ... Dunning, A. M. (2016). Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs). Scientific Reports, 6, 1-14. Article 32512. https://doi.org/10.1038/srep32512

Darabi, H, Beesley, J, Droit, A, Kar, S, Nord, S, Moradi Marjaneh, M, Soucy, P, Michailidou, K, Ghoussaini, M, Fues Wahl, H, Bolla, MK, Wang, Q, Dennis, J, Alonso, MR, Andrulis, IL, Anton-Culver, H, Arndt, V, Beckmann, MW, Benitez, J, Bogdanova, NV, Bojesen, SE, Brauch, H, Brenner, H, Broeks, A, Brüning, T, Burwinkel, B, Chang-Claude, J, Choi, J-Y, Conroy, DM, Couch, FJ, Cox, A, Cross, SS, Czene, K, Devilee, P, Dörk, T, Easton, DF, Fasching, PA, Figueroa, J, Fletcher, O, Flyger, H, Galle, E, García-Closas, M, Giles, GG, Goldberg, MS, González-Neira, A, Guénel, P, Haiman, CA, Hallberg, E, Hamann, U, Hartman, M, Hollestelle, A, Hopper, JL, Ito, H, Jakubowska, A, Johnson, N, Kang, D, Khan, S, Kosma, V-M, Kriege, M, Kristensen, V, Lambrechts, D, Le Marchand, L, Lee, SC, Lindblom, A, Lophatananon, A, Lubinski, J, Mannermaa, A, Manoukian, S, Margolin, S, Matsuo, K, Mayes, R, McKay, J, Meindl, A, Milne, RL, Muir, K, Neuhausen, SL, Nevanlinna, H, Olswold, C, Orr, N, Peterlongo, P, Pita, G, Pylkäs, K, Rudolph, A, Sangrajrang, S, Sawyer, EJ, Schmidt, MK, Schmutzler, RK, Seynaeve, C, Shah, M, Shen, C-Y, Shu, X-O, Southey, MC, Stram, DO, Surowy, H, Swerdlow, A, Teo, SH, Tessier, DC, Tomlinson, I, Torres, D, Truong, T, Vachon, CM, Vincent, D, Winqvist, R, Wu, AH, Wu, P-E, Yip, CH, Zheng, W, Pharoah, PDP, Hall, P, Edwards, SL, Simard, J, French, JD, Chenevix-Trench, G & Dunning, AM 2016, 'Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)', Scientific Reports, vol. 6, 32512, pp. 1-14. https://doi.org/10.1038/srep32512

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T1 - Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)

AU - Darabi, Hatef

AU - Beesley, Jonathan

AU - Droit, Arnaud

AU - Kar, Siddhartha

AU - Nord, Silje

AU - Moradi Marjaneh, Mahdi

AU - Soucy, Penny

AU - Michailidou, Kyriaki

AU - Ghoussaini, Maya

AU - Fues Wahl, Hanna

AU - Bolla, Manjeet K

AU - Wang, Qin

AU - Dennis, Joe

AU - Alonso, M Rosario

AU - Andrulis, Irene L

AU - Anton-Culver, Hoda

AU - Arndt, Volker

AU - Beckmann, Matthias W

AU - Benitez, Javier

AU - Bogdanova, Natalia V

AU - Bojesen, Stig E

AU - Brauch, Hiltrud

AU - Brenner, Hermann

AU - Broeks, Annegien

AU - Brüning, Thomas

AU - Burwinkel, Barbara

AU - Chang-Claude, Jenny

AU - Choi, Ji-Yeob

AU - Conroy, Don M

AU - Couch, Fergus J

AU - Cox, Angela

AU - Cross, Simon S

AU - Czene, Kamila

AU - Devilee, Peter

AU - Dörk, Thilo

AU - Easton, Douglas F

AU - Fasching, Peter A

AU - Figueroa, Jonine

AU - Fletcher, Olivia

AU - Flyger, Henrik

AU - Galle, Eva

AU - García-Closas, Montserrat

AU - Giles, Graham G

AU - Goldberg, Mark S

AU - González-Neira, Anna

AU - Guénel, Pascal

AU - Haiman, Christopher A

AU - Hallberg, Emily

AU - Hamann, Ute

AU - Hartman, Mikael

AU - Hollestelle, Antoinette

AU - Hopper, John L

AU - Ito, Hidemi

AU - Jakubowska, Anna

AU - Johnson, Nichola

AU - Kang, Daehee

AU - Khan, Sofia

AU - Kosma, Veli-Matti

AU - Kriege, Mieke

AU - Kristensen, Vessela

AU - Lambrechts, Diether

AU - Le Marchand, Loic

AU - Lee, Soo Chin

AU - Lindblom, Annika

AU - Lophatananon, Artitaya

AU - Lubinski, Jan

AU - Mannermaa, Arto

AU - Manoukian, Siranoush

AU - Margolin, Sara

AU - Matsuo, Keitaro

AU - Mayes, Rebecca

AU - McKay, James

AU - Meindl, Alfons

AU - Milne, Roger L

AU - Muir, Kenneth

AU - Neuhausen, Susan L

AU - Nevanlinna, Heli

AU - Olswold, Curtis

AU - Orr, Nick

AU - Peterlongo, Paolo

AU - Pita, Guillermo

AU - Pylkäs, Katri

AU - Rudolph, Anja

AU - Sangrajrang, Suleeporn

AU - Sawyer, Elinor J

AU - Schmidt, Marjanka K

AU - Schmutzler, Rita K

AU - Seynaeve, Caroline

AU - Shah, Mitul

AU - Shen, Chen-Yang

AU - Shu, Xiao-Ou

AU - Southey, Melissa C

AU - Stram, Daniel O

AU - Surowy, Harald

AU - Swerdlow, Anthony

AU - Teo, Soo H

AU - Tessier, Daniel C

AU - Tomlinson, Ian

AU - Torres, Diana

AU - Truong, Thérèse

AU - Vachon, Celine M

AU - Vincent, Daniel

AU - Winqvist, Robert

AU - Wu, Anna H

AU - Wu, Pei-Ei

AU - Yip, Cheng Har

AU - Zheng, Wei

AU - Pharoah, Paul D P

AU - Hall, Per

AU - Edwards, Stacey L

AU - Simard, Jacques

AU - French, Juliet D

AU - Chenevix-Trench, Georgia

AU - Dunning, Alison M

PY - 2016/9/7

Y1 - 2016/9/7

N2 - Genome-wide association studies have found SNPs at 17q22 to be associated with breast cancer risk. To identify potential causal variants related to breast cancer risk, we performed a high resolution fine-mapping analysis that involved genotyping 517 SNPs using a custom Illumina iSelect array (iCOGS) followed by imputation of genotypes for 3,134 SNPs in more than 89,000 participants of European ancestry from the Breast Cancer Association Consortium (BCAC). We identified 28 highly correlated common variants, in a 53 Kb region spanning two introns of the STXBP4 gene, that are strong candidates for driving breast cancer risk (lead SNP rs2787486 (OR = 0.92; CI 0.90-0.94; P = 8.96 × 10(-15))) and are correlated with two previously reported risk-associated variants at this locus, SNPs rs6504950 (OR = 0.94, P = 2.04 × 10(-09), r(2) = 0.73 with lead SNP) and rs1156287 (OR = 0.93, P = 3.41 × 10(-11), r(2) = 0.83 with lead SNP). Analyses indicate only one causal SNP in the region and several enhancer elements targeting STXBP4 are located within the 53 kb association signal. Expression studies in breast tumor tissues found SNP rs2787486 to be associated with increased STXBP4 expression, suggesting this may be a target gene of this locus.

AB - Genome-wide association studies have found SNPs at 17q22 to be associated with breast cancer risk. To identify potential causal variants related to breast cancer risk, we performed a high resolution fine-mapping analysis that involved genotyping 517 SNPs using a custom Illumina iSelect array (iCOGS) followed by imputation of genotypes for 3,134 SNPs in more than 89,000 participants of European ancestry from the Breast Cancer Association Consortium (BCAC). We identified 28 highly correlated common variants, in a 53 Kb region spanning two introns of the STXBP4 gene, that are strong candidates for driving breast cancer risk (lead SNP rs2787486 (OR = 0.92; CI 0.90-0.94; P = 8.96 × 10(-15))) and are correlated with two previously reported risk-associated variants at this locus, SNPs rs6504950 (OR = 0.94, P = 2.04 × 10(-09), r(2) = 0.73 with lead SNP) and rs1156287 (OR = 0.93, P = 3.41 × 10(-11), r(2) = 0.83 with lead SNP). Analyses indicate only one causal SNP in the region and several enhancer elements targeting STXBP4 are located within the 53 kb association signal. Expression studies in breast tumor tissues found SNP rs2787486 to be associated with increased STXBP4 expression, suggesting this may be a target gene of this locus.

KW - Journal Article

U2 - 10.1038/srep32512

DO - 10.1038/srep32512

M3 - Journal article

C2 - 27600471

SN - 2045-2322

VL - 6

SP - 1

EP - 14

JO - Scientific Reports

JF - Scientific Reports

M1 - 32512

ER -

Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)

Abstract

Keywords

UN SDGs

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