Fighting cancer using an oncofetal glycosaminoglycan-binding protein from malaria parasites

Mette Agerbæk; Sara Bang-Christensen; Ali Salanti

doi:10.1016/j.pt.2018.11.004

Fighting cancer using an oncofetal glycosaminoglycan-binding protein from malaria parasites

Mette Agerbæk, Sara Bang-Christensen, Ali Salanti^*

^*Corresponding author for this work

VAR2CSA team

5 Citations (Scopus)

Abstract

Malaria research has led to the discovery of oncofetal chondroitin sulfate, which appears to be shared between placental trophoblasts and cancer cells and can be detected by the evolutionary refined malaria protein VAR2CSA. Interestingly, using recombinant VAR2CSA to target oncofetal chondroitin sulfate shows promise for novel cancer diagnostics and therapeutics.

Original language	English
Journal	Trends in Parasitology
Volume	35
Issue number	3
Pages (from-to)	178-181
ISSN	1471-4922
DOIs	https://doi.org/10.1016/j.pt.2018.11.004
Publication status	Published - Mar 2019

Keywords

cancer
oncofetal chondroitin sulfate
placental malaria
VAR2CSA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pt.2018.11.004

Cite this

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title = "Fighting cancer using an oncofetal glycosaminoglycan-binding protein from malaria parasites",

abstract = "Malaria research has led to the discovery of oncofetal chondroitin sulfate, which appears to be shared between placental trophoblasts and cancer cells and can be detected by the evolutionary refined malaria protein VAR2CSA. Interestingly, using recombinant VAR2CSA to target oncofetal chondroitin sulfate shows promise for novel cancer diagnostics and therapeutics.",

keywords = "cancer, oncofetal chondroitin sulfate, placental malaria, VAR2CSA",

author = "Mette Agerb{\ae}k and Sara Bang-Christensen and Ali Salanti",

year = "2019",

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T1 - Fighting cancer using an oncofetal glycosaminoglycan-binding protein from malaria parasites

AU - Agerbæk, Mette

AU - Bang-Christensen, Sara

AU - Salanti, Ali

PY - 2019/3

Y1 - 2019/3

N2 - Malaria research has led to the discovery of oncofetal chondroitin sulfate, which appears to be shared between placental trophoblasts and cancer cells and can be detected by the evolutionary refined malaria protein VAR2CSA. Interestingly, using recombinant VAR2CSA to target oncofetal chondroitin sulfate shows promise for novel cancer diagnostics and therapeutics.

AB - Malaria research has led to the discovery of oncofetal chondroitin sulfate, which appears to be shared between placental trophoblasts and cancer cells and can be detected by the evolutionary refined malaria protein VAR2CSA. Interestingly, using recombinant VAR2CSA to target oncofetal chondroitin sulfate shows promise for novel cancer diagnostics and therapeutics.

KW - cancer

KW - oncofetal chondroitin sulfate

KW - placental malaria

KW - VAR2CSA

U2 - 10.1016/j.pt.2018.11.004

DO - 10.1016/j.pt.2018.11.004

M3 - Journal article

C2 - 30551869

AN - SCOPUS:85058018294

SN - 1471-4922

VL - 35

SP - 178

EP - 181

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 3

ER -

Fighting cancer using an oncofetal glycosaminoglycan-binding protein from malaria parasites

Abstract

Keywords

UN SDGs

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