Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome

Yoav Michowitz; Anat Milman; Georgia Sarquella-Brugada; Antoine Andorin; Jean Champagne; Pieter G. Postema; Ruben Casado-Arroyo; Eran Leshem; Jimmy J.M. Juang; Carla Giustetto; Jacob Tfelt-Hansen; Yanushi D. Wijeyeratne; Christian Veltmann; Domenico Corrado; Sung Hwan Kim; Pietro Delise; Shingo Maeda; Jean Baptiste Gourraud; Frederic Sacher; Philippe Mabo; Yoshihide Takahashi; Tsukasa Kamakura; Takeshi Aiba; Giulio Conte; Aviram Hochstadt; Yuka Mizusawa; Michael Rahkovich; Elena Arbelo; Zhengrong Huang; Isabelle Denjoy; Carlo Napolitano; Ramon Brugada; Leonardo Calo; Silvia G. Priori; Masahiko Takagi; Elijah R. Behr; Fiorenzo Gaita; Gan Xin Yan; Josep Brugada; Antoine Leenhardt; Arthur A.M. Wilde; Pedro Brugada; Kengo F. Kusano; Kenzo Hirao; Gi Byoung Nam; Vincent Probst; Bernard Belhassen

doi:10.1016/j.hrthm.2018.04.007

Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome

Yoav Michowitz, Anat Milman, Georgia Sarquella-Brugada, Antoine Andorin, Jean Champagne, Pieter G. Postema, Ruben Casado-Arroyo, Eran Leshem, Jimmy J.M. Juang, Carla Giustetto, Jacob Tfelt-Hansen, Yanushi D. Wijeyeratne, Christian Veltmann, Domenico Corrado, Sung Hwan Kim, Pietro Delise, Shingo Maeda, Jean Baptiste Gourraud, Frederic Sacher, Philippe MaboYoshihide Takahashi, Tsukasa Kamakura, Takeshi Aiba, Giulio Conte, Aviram Hochstadt, Yuka Mizusawa, Michael Rahkovich, Elena Arbelo, Zhengrong Huang, Isabelle Denjoy, Carlo Napolitano, Ramon Brugada, Leonardo Calo, Silvia G. Priori, Masahiko Takagi, Elijah R. Behr, Fiorenzo Gaita, Gan Xin Yan, Josep Brugada, Antoine Leenhardt, Arthur A.M. Wilde, Pedro Brugada, Kengo F. Kusano, Kenzo Hirao, Gi Byoung Nam, Vincent Probst, Bernard Belhassen^*

^*Corresponding author for this work

34 Citations (Scopus)

Abstract

Background: The literature on fever-related arrhythmic events (AEs) in Brugada syndrome (BrS) is currently limited to few case reports and small series. Objective: The present study aimed to describe the characteristics of fever-related AE in a large cohort of patients with BrS. Methods: The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter study on 678 patients with BrS with first AE documented at the time of aborted cardiac arrest (n = 426) or after prophylactic implantable cardioverter-defibrillator implantation (n = 252). Results: In 35 of 588 patients (6%) with available information, the AE occurred during a febrile illness. Most of the 35 patients were male (80%), Caucasian (83%), and proband (70%). The mean age at the time of AE was 29 ± 24 years (range 0.3–76 years). Most patients (80%) presented with aborted cardiac arrest and 6 (17%) with arrhythmic storm. Family history of sudden death, history of syncope, and spontaneous type 1 Brugada electrocardiogram were noted in 17%, 40%, and 71% of patients, respectively. Ventricular fibrillation was induced at electrophysiology study in 9 of 19 patients (47%). An SCN5A mutation was found in 14 of 28 patients (50%). The highest proportion of fever-related AE was observed in the pediatric population (age <16 years), with a disproportionally higher event rate in the very young (age 0–5 years) (65%). Males were involved in all age groups and females only in the pediatric and elderly groups. Fever-related AE affected 17 Caucasians aged <24 years, but no Asians aged <24 years. Conclusion: The risk of fever-related AE in BrS markedly varies according to age group, sex, and ethnicity. Taking these factors into account could help the clinical management of patients with BrS with fever.

Original language	English
Journal	Heart Rhythm
Volume	15
Issue number	9
Pages (from-to)	1394-1401
Number of pages	8
ISSN	1547-5271
DOIs	https://doi.org/10.1016/j.hrthm.2018.04.007
Publication status	Published - 1 Sept 2018

Keywords

Brugada syndrome
Children
Elderly
Ethnicity
Fever
Sex

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Michowitz, Y., Milman, A., Sarquella-Brugada, G., Andorin, A., Champagne, J., Postema, P. G., Casado-Arroyo, R., Leshem, E., Juang, J. J. M., Giustetto, C., Tfelt-Hansen, J., Wijeyeratne, Y. D., Veltmann, C., Corrado, D., Kim, S. H., Delise, P., Maeda, S., Gourraud, J. B., Sacher, F., ... Belhassen, B. (2018). Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome. Heart Rhythm, 15(9), 1394-1401. https://doi.org/10.1016/j.hrthm.2018.04.007

Michowitz, Y, Milman, A, Sarquella-Brugada, G, Andorin, A, Champagne, J, Postema, PG, Casado-Arroyo, R, Leshem, E, Juang, JJM, Giustetto, C, Tfelt-Hansen, J, Wijeyeratne, YD, Veltmann, C, Corrado, D, Kim, SH, Delise, P, Maeda, S, Gourraud, JB, Sacher, F, Mabo, P, Takahashi, Y, Kamakura, T, Aiba, T, Conte, G, Hochstadt, A, Mizusawa, Y, Rahkovich, M, Arbelo, E, Huang, Z, Denjoy, I, Napolitano, C, Brugada, R, Calo, L, Priori, SG, Takagi, M, Behr, ER, Gaita, F, Yan, GX, Brugada, J, Leenhardt, A, Wilde, AAM, Brugada, P, Kusano, KF, Hirao, K, Nam, GB, Probst, V & Belhassen, B 2018, 'Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome', Heart Rhythm, vol. 15, no. 9, pp. 1394-1401. https://doi.org/10.1016/j.hrthm.2018.04.007

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title = "Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome",

abstract = "Background: The literature on fever-related arrhythmic events (AEs) in Brugada syndrome (BrS) is currently limited to few case reports and small series. Objective: The present study aimed to describe the characteristics of fever-related AE in a large cohort of patients with BrS. Methods: The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter study on 678 patients with BrS with first AE documented at the time of aborted cardiac arrest (n = 426) or after prophylactic implantable cardioverter-defibrillator implantation (n = 252). Results: In 35 of 588 patients (6%) with available information, the AE occurred during a febrile illness. Most of the 35 patients were male (80%), Caucasian (83%), and proband (70%). The mean age at the time of AE was 29 ± 24 years (range 0.3–76 years). Most patients (80%) presented with aborted cardiac arrest and 6 (17%) with arrhythmic storm. Family history of sudden death, history of syncope, and spontaneous type 1 Brugada electrocardiogram were noted in 17%, 40%, and 71% of patients, respectively. Ventricular fibrillation was induced at electrophysiology study in 9 of 19 patients (47%). An SCN5A mutation was found in 14 of 28 patients (50%). The highest proportion of fever-related AE was observed in the pediatric population (age <16 years), with a disproportionally higher event rate in the very young (age 0–5 years) (65%). Males were involved in all age groups and females only in the pediatric and elderly groups. Fever-related AE affected 17 Caucasians aged <24 years, but no Asians aged <24 years. Conclusion: The risk of fever-related AE in BrS markedly varies according to age group, sex, and ethnicity. Taking these factors into account could help the clinical management of patients with BrS with fever.",

keywords = "Brugada syndrome, Children, Elderly, Ethnicity, Fever, Sex",

author = "Yoav Michowitz and Anat Milman and Georgia Sarquella-Brugada and Antoine Andorin and Jean Champagne and Postema, {Pieter G.} and Ruben Casado-Arroyo and Eran Leshem and Juang, {Jimmy J.M.} and Carla Giustetto and Jacob Tfelt-Hansen and Wijeyeratne, {Yanushi D.} and Christian Veltmann and Domenico Corrado and Kim, {Sung Hwan} and Pietro Delise and Shingo Maeda and Gourraud, {Jean Baptiste} and Frederic Sacher and Philippe Mabo and Yoshihide Takahashi and Tsukasa Kamakura and Takeshi Aiba and Giulio Conte and Aviram Hochstadt and Yuka Mizusawa and Michael Rahkovich and Elena Arbelo and Zhengrong Huang and Isabelle Denjoy and Carlo Napolitano and Ramon Brugada and Leonardo Calo and Priori, {Silvia G.} and Masahiko Takagi and Behr, {Elijah R.} and Fiorenzo Gaita and Yan, {Gan Xin} and Josep Brugada and Antoine Leenhardt and Wilde, {Arthur A.M.} and Pedro Brugada and Kusano, {Kengo F.} and Kenzo Hirao and Nam, {Gi Byoung} and Vincent Probst and Bernard Belhassen",

year = "2018",

month = sep,

day = "1",

doi = "10.1016/j.hrthm.2018.04.007",

language = "English",

volume = "15",

pages = "1394--1401",

journal = "Heart Rhythm",

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number = "9",

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T1 - Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome

AU - Michowitz, Yoav

AU - Milman, Anat

AU - Sarquella-Brugada, Georgia

AU - Andorin, Antoine

AU - Champagne, Jean

AU - Postema, Pieter G.

AU - Casado-Arroyo, Ruben

AU - Leshem, Eran

AU - Juang, Jimmy J.M.

AU - Giustetto, Carla

AU - Tfelt-Hansen, Jacob

AU - Wijeyeratne, Yanushi D.

AU - Veltmann, Christian

AU - Corrado, Domenico

AU - Kim, Sung Hwan

AU - Delise, Pietro

AU - Maeda, Shingo

AU - Gourraud, Jean Baptiste

AU - Sacher, Frederic

AU - Mabo, Philippe

AU - Takahashi, Yoshihide

AU - Kamakura, Tsukasa

AU - Aiba, Takeshi

AU - Conte, Giulio

AU - Hochstadt, Aviram

AU - Mizusawa, Yuka

AU - Rahkovich, Michael

AU - Arbelo, Elena

AU - Huang, Zhengrong

AU - Denjoy, Isabelle

AU - Napolitano, Carlo

AU - Brugada, Ramon

AU - Calo, Leonardo

AU - Priori, Silvia G.

AU - Takagi, Masahiko

AU - Behr, Elijah R.

AU - Gaita, Fiorenzo

AU - Yan, Gan Xin

AU - Brugada, Josep

AU - Leenhardt, Antoine

AU - Wilde, Arthur A.M.

AU - Brugada, Pedro

AU - Kusano, Kengo F.

AU - Hirao, Kenzo

AU - Nam, Gi Byoung

AU - Probst, Vincent

AU - Belhassen, Bernard

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background: The literature on fever-related arrhythmic events (AEs) in Brugada syndrome (BrS) is currently limited to few case reports and small series. Objective: The present study aimed to describe the characteristics of fever-related AE in a large cohort of patients with BrS. Methods: The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter study on 678 patients with BrS with first AE documented at the time of aborted cardiac arrest (n = 426) or after prophylactic implantable cardioverter-defibrillator implantation (n = 252). Results: In 35 of 588 patients (6%) with available information, the AE occurred during a febrile illness. Most of the 35 patients were male (80%), Caucasian (83%), and proband (70%). The mean age at the time of AE was 29 ± 24 years (range 0.3–76 years). Most patients (80%) presented with aborted cardiac arrest and 6 (17%) with arrhythmic storm. Family history of sudden death, history of syncope, and spontaneous type 1 Brugada electrocardiogram were noted in 17%, 40%, and 71% of patients, respectively. Ventricular fibrillation was induced at electrophysiology study in 9 of 19 patients (47%). An SCN5A mutation was found in 14 of 28 patients (50%). The highest proportion of fever-related AE was observed in the pediatric population (age <16 years), with a disproportionally higher event rate in the very young (age 0–5 years) (65%). Males were involved in all age groups and females only in the pediatric and elderly groups. Fever-related AE affected 17 Caucasians aged <24 years, but no Asians aged <24 years. Conclusion: The risk of fever-related AE in BrS markedly varies according to age group, sex, and ethnicity. Taking these factors into account could help the clinical management of patients with BrS with fever.

AB - Background: The literature on fever-related arrhythmic events (AEs) in Brugada syndrome (BrS) is currently limited to few case reports and small series. Objective: The present study aimed to describe the characteristics of fever-related AE in a large cohort of patients with BrS. Methods: The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter study on 678 patients with BrS with first AE documented at the time of aborted cardiac arrest (n = 426) or after prophylactic implantable cardioverter-defibrillator implantation (n = 252). Results: In 35 of 588 patients (6%) with available information, the AE occurred during a febrile illness. Most of the 35 patients were male (80%), Caucasian (83%), and proband (70%). The mean age at the time of AE was 29 ± 24 years (range 0.3–76 years). Most patients (80%) presented with aborted cardiac arrest and 6 (17%) with arrhythmic storm. Family history of sudden death, history of syncope, and spontaneous type 1 Brugada electrocardiogram were noted in 17%, 40%, and 71% of patients, respectively. Ventricular fibrillation was induced at electrophysiology study in 9 of 19 patients (47%). An SCN5A mutation was found in 14 of 28 patients (50%). The highest proportion of fever-related AE was observed in the pediatric population (age <16 years), with a disproportionally higher event rate in the very young (age 0–5 years) (65%). Males were involved in all age groups and females only in the pediatric and elderly groups. Fever-related AE affected 17 Caucasians aged <24 years, but no Asians aged <24 years. Conclusion: The risk of fever-related AE in BrS markedly varies according to age group, sex, and ethnicity. Taking these factors into account could help the clinical management of patients with BrS with fever.

KW - Brugada syndrome

KW - Children

KW - Elderly

KW - Ethnicity

KW - Fever

KW - Sex

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U2 - 10.1016/j.hrthm.2018.04.007

DO - 10.1016/j.hrthm.2018.04.007

M3 - Journal article

C2 - 29649615

AN - SCOPUS:85047178178

SN - 1547-5271

VL - 15

SP - 1394

EP - 1401

JO - Heart Rhythm

JF - Heart Rhythm

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ER -

Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome

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Keywords

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