Fetal gender and several cytokines are associated with the number of fetal cells in maternal blood: an observational study

Jacob Mørup Schlütter; Ida Kirkegaard; Olav Bjørn Petersen; Nanna Larsen; Britta Christensen; David M Hougaard; Steen Kølvraa; Niels Uldbjerg

doi:10.1371/journal.pone.0106934

Fetal gender and several cytokines are associated with the number of fetal cells in maternal blood: an observational study

Jacob Mørup Schlütter, Ida Kirkegaard, Olav Bjørn Petersen, Nanna Larsen, Britta Christensen, David M Hougaard, Steen Kølvraa, Niels Uldbjerg

11 Citations (Scopus)

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Abstract

OBJECTIVE: To identify factors influencing the number of fetal cells in maternal blood.

METHODS: A total of 57 pregnant women at a gestational age of weeks 11-14 were included. The number of fetal cells in maternal blood was assessed in 30 ml of blood using specific markers for both enrichment and subsequent identification.

RESULTS: Participants carrying male fetuses had a higher median number of fetal cells in maternal blood than those carrying female fetuses (5 vs. 3, p = 0.04). Certain cytokines (RANTES, IL-2 and IL-5) were significantly associated with the number of fetal cells in maternal blood.

CONCLUSION: The number of fetal cells in maternal blood is associated with certain cytokines and fetal gender.

Original language	English
Article number	e106934
Journal	PLoS ONE
Volume	9
Issue number	9
Number of pages	7
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0106934
Publication status	Published - 2014
Externally published	Yes

Keywords

Adult
Cell Count
Cell Lineage/immunology
Cell Separation
Cell Tracking
Chemokine CCL5/blood
Female
Fetal Blood/cytology
Fetus/cytology
Gestational Age
Humans
Interleukin-2/blood
Interleukin-5/blood
Male
Pregnancy
Sex Characteristics
Sex Factors

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journal.pone.0106934Final published version, 422 KBLicence: CC BY

Cite this

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title = "Fetal gender and several cytokines are associated with the number of fetal cells in maternal blood: an observational study",

abstract = "OBJECTIVE: To identify factors influencing the number of fetal cells in maternal blood.METHODS: A total of 57 pregnant women at a gestational age of weeks 11-14 were included. The number of fetal cells in maternal blood was assessed in 30 ml of blood using specific markers for both enrichment and subsequent identification.RESULTS: Participants carrying male fetuses had a higher median number of fetal cells in maternal blood than those carrying female fetuses (5 vs. 3, p = 0.04). Certain cytokines (RANTES, IL-2 and IL-5) were significantly associated with the number of fetal cells in maternal blood.CONCLUSION: The number of fetal cells in maternal blood is associated with certain cytokines and fetal gender.",

keywords = "Adult, Cell Count, Cell Lineage/immunology, Cell Separation, Cell Tracking, Chemokine CCL5/blood, Female, Fetal Blood/cytology, Fetus/cytology, Gestational Age, Humans, Interleukin-2/blood, Interleukin-5/blood, Male, Pregnancy, Sex Characteristics, Sex Factors",

author = "Schl{\"u}tter, {Jacob M{\o}rup} and Ida Kirkegaard and Petersen, {Olav Bj{\o}rn} and Nanna Larsen and Britta Christensen and Hougaard, {David M} and Steen K{\o}lvraa and Niels Uldbjerg",

year = "2014",

doi = "10.1371/journal.pone.0106934",

language = "English",

volume = "9",

journal = "PLoS ONE",

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TY - JOUR

T1 - Fetal gender and several cytokines are associated with the number of fetal cells in maternal blood

T2 - an observational study

AU - Schlütter, Jacob Mørup

AU - Kirkegaard, Ida

AU - Petersen, Olav Bjørn

AU - Larsen, Nanna

AU - Christensen, Britta

AU - Hougaard, David M

AU - Kølvraa, Steen

AU - Uldbjerg, Niels

PY - 2014

Y1 - 2014

N2 - OBJECTIVE: To identify factors influencing the number of fetal cells in maternal blood.METHODS: A total of 57 pregnant women at a gestational age of weeks 11-14 were included. The number of fetal cells in maternal blood was assessed in 30 ml of blood using specific markers for both enrichment and subsequent identification.RESULTS: Participants carrying male fetuses had a higher median number of fetal cells in maternal blood than those carrying female fetuses (5 vs. 3, p = 0.04). Certain cytokines (RANTES, IL-2 and IL-5) were significantly associated with the number of fetal cells in maternal blood.CONCLUSION: The number of fetal cells in maternal blood is associated with certain cytokines and fetal gender.

AB - OBJECTIVE: To identify factors influencing the number of fetal cells in maternal blood.METHODS: A total of 57 pregnant women at a gestational age of weeks 11-14 were included. The number of fetal cells in maternal blood was assessed in 30 ml of blood using specific markers for both enrichment and subsequent identification.RESULTS: Participants carrying male fetuses had a higher median number of fetal cells in maternal blood than those carrying female fetuses (5 vs. 3, p = 0.04). Certain cytokines (RANTES, IL-2 and IL-5) were significantly associated with the number of fetal cells in maternal blood.CONCLUSION: The number of fetal cells in maternal blood is associated with certain cytokines and fetal gender.

KW - Adult

KW - Cell Count

KW - Cell Lineage/immunology

KW - Cell Separation

KW - Cell Tracking

KW - Chemokine CCL5/blood

KW - Female

KW - Fetal Blood/cytology

KW - Fetus/cytology

KW - Gestational Age

KW - Humans

KW - Interleukin-2/blood

KW - Interleukin-5/blood

KW - Male

KW - Pregnancy

KW - Sex Characteristics

KW - Sex Factors

U2 - 10.1371/journal.pone.0106934

DO - 10.1371/journal.pone.0106934

M3 - Journal article

C2 - 25188498

SN - 1932-6203

VL - 9

JO - PLoS ONE

JF - PLoS ONE

IS - 9

M1 - e106934

ER -

Fetal gender and several cytokines are associated with the number of fetal cells in maternal blood: an observational study

Abstract

Keywords

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