Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing

D Andrew Crain, Sarah J Janssen, Thea M Edwards, Jerrold Heindel, Shuk-mei Ho, Patricia Hunt, Taisen Iguchi, Anders Juul, John A McLachlan, Jackie Schwartz, Niels Skakkebaek, Ana M Soto, Shanna Swan, Cheryl Walker, Teresa K Woodruff, Tracey J Woodruff, Linda C Giudice, Louis J Guillette

296 Citations (Scopus)

Abstract

To evaluate the possible role of endocrine-disrupting compounds (EDCs) on female reproductive disorders emphasizing developmental plasticity and the complexity of endocrine-dependent ontogeny of reproductive organs. Declining conception rates and the high incidence of female reproductive disruptions warrant evaluation of the impact of EDCs on female reproductive health.
Original languageEnglish
JournalFertility and Sterility
Volume90
Issue number4
Pages (from-to)911-40
Number of pages30
ISSN0015-0282
DOIs
Publication statusPublished - 2008

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