FcGammaRIIa polymorphism and anti-malaria specific IgG and IgG subclass responses in populations differing in susceptibility to malaria in Burkina Faso

Mariama K Cherif; Guillaume S Sanou; Boubakar Maiga; Israelsson Elisabeth; André Lin Ouédraogo; Edith C Bougouma; Amidou Diarra; Alphonse Ouédraogo; Aboubacar S Ouattara; Marita Troye-Blomberg; Amagana Dolo; David R Cavanagh; Michael Theisen; David Modiano; Sodiomon B Sirima; Issa Nebié

doi:10.1111/j.1365-3083.2012.02690.x

FcGammaRIIa polymorphism and anti-malaria specific IgG and IgG subclass responses in populations differing in susceptibility to malaria in Burkina Faso

Mariama K Cherif, Guillaume S Sanou, Boubakar Maiga, Israelsson Elisabeth, André Lin Ouédraogo, Edith C Bougouma, Amidou Diarra, Alphonse Ouédraogo, Aboubacar S Ouattara, Marita Troye-Blomberg, Amagana Dolo, David R Cavanagh, Michael Theisen, David Modiano, Sodiomon B Sirima, Issa Nebié

11 Citations (Scopus)

Abstract

FcγRIIa is known to be polymorphic; and certain variants are associated with different susceptibilities to malaria. Studies involving the Fulani ethnic group reported an ethnic difference in FcγRIIa-R131H genotype frequencies between the Fulani and other sympatric groups. No previous studies have addressed these questions in Burkina Faso. This study aimed to assess the influence of FcγRIIa-R131H polymorphism on anti-falciparum malaria IgG and IgG subclass responses in the Fulani and the Mossi ethnic groups living in Burkina Faso. Healthy adults more than 20years old belonging to the Mossi or the Fulani ethnic groups were enrolled for the assessment of selected parasitological, immunological and genetic variables in relation to their susceptibility to malaria. The prevalence of the Plasmodium falciparum infection frequency was relatively low in the Fulani ethnic group compared to the Mossi ethnic group. For all tested antigens, the Fulani had higher antibody levels than the Mossi group. In both ethnic groups, a similar distribution of FcγRIIa R131H polymorphism was found. Individuals with the R allele of FcγRIIa had higher antibody levels than those with the H allele. This study confirmed that malaria infection affected less the Fulani group than the Mossi group. FcγRIIa-R131H allele distribution is similar in both ethnic groups, and higher antibody levels are associated with the FcγRIIa R allele compared to the H allele.

Original language	English
Journal	Scandinavian Journal of Immunology
Volume	75
Issue number	6
Pages (from-to)	606-613
ISSN	0300-9475
DOIs	https://doi.org/10.1111/j.1365-3083.2012.02690.x
Publication status	Published - Jun 2012

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Cherif, M. K., Sanou, G. S., Maiga, B., Elisabeth, I., Ouédraogo, A. L., Bougouma, E. C., Diarra, A., Ouédraogo, A., Ouattara, A. S., Troye-Blomberg, M., Dolo, A., Cavanagh, D. R., Theisen, M., Modiano, D., Sirima, S. B., & Nebié, I. (2012). FcGammaRIIa polymorphism and anti-malaria specific IgG and IgG subclass responses in populations differing in susceptibility to malaria in Burkina Faso. Scandinavian Journal of Immunology, 75(6), 606-613. https://doi.org/10.1111/j.1365-3083.2012.02690.x

FcGammaRIIa polymorphism and anti-malaria specific IgG and IgG subclass responses in populations differing in susceptibility to malaria in Burkina Faso. / Cherif, Mariama K; Sanou, Guillaume S; Maiga, Boubakar et al.

In: Scandinavian Journal of Immunology, Vol. 75, No. 6, 06.2012, p. 606-613.

Research output: Contribution to journal › Journal article › Research › peer-review

Cherif, MK, Sanou, GS, Maiga, B, Elisabeth, I, Ouédraogo, AL, Bougouma, EC, Diarra, A, Ouédraogo, A, Ouattara, AS, Troye-Blomberg, M, Dolo, A, Cavanagh, DR, Theisen, M, Modiano, D, Sirima, SB & Nebié, I 2012, 'FcGammaRIIa polymorphism and anti-malaria specific IgG and IgG subclass responses in populations differing in susceptibility to malaria in Burkina Faso', Scandinavian Journal of Immunology, vol. 75, no. 6, pp. 606-613. https://doi.org/10.1111/j.1365-3083.2012.02690.x

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title = "FcGammaRIIa polymorphism and anti-malaria specific IgG and IgG subclass responses in populations differing in susceptibility to malaria in Burkina Faso",

abstract = "FcγRIIa is known to be polymorphic; and certain variants are associated with different susceptibilities to malaria. Studies involving the Fulani ethnic group reported an ethnic difference in FcγRIIa-R131H genotype frequencies between the Fulani and other sympatric groups. No previous studies have addressed these questions in Burkina Faso. This study aimed to assess the influence of FcγRIIa-R131H polymorphism on anti-falciparum malaria IgG and IgG subclass responses in the Fulani and the Mossi ethnic groups living in Burkina Faso. Healthy adults more than 20years old belonging to the Mossi or the Fulani ethnic groups were enrolled for the assessment of selected parasitological, immunological and genetic variables in relation to their susceptibility to malaria. The prevalence of the Plasmodium falciparum infection frequency was relatively low in the Fulani ethnic group compared to the Mossi ethnic group. For all tested antigens, the Fulani had higher antibody levels than the Mossi group. In both ethnic groups, a similar distribution of FcγRIIa R131H polymorphism was found. Individuals with the R allele of FcγRIIa had higher antibody levels than those with the H allele. This study confirmed that malaria infection affected less the Fulani group than the Mossi group. FcγRIIa-R131H allele distribution is similar in both ethnic groups, and higher antibody levels are associated with the FcγRIIa R allele compared to the H allele.",

author = "Cherif, {Mariama K} and Sanou, {Guillaume S} and Boubakar Maiga and Israelsson Elisabeth and Ou{\'e}draogo, {Andr{\'e} Lin} and Bougouma, {Edith C} and Amidou Diarra and Alphonse Ou{\'e}draogo and Ouattara, {Aboubacar S} and Marita Troye-Blomberg and Amagana Dolo and Cavanagh, {David R} and Michael Theisen and David Modiano and Sirima, {Sodiomon B} and Issa Nebi{\'e}",

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T1 - FcGammaRIIa polymorphism and anti-malaria specific IgG and IgG subclass responses in populations differing in susceptibility to malaria in Burkina Faso

AU - Cherif, Mariama K

AU - Sanou, Guillaume S

AU - Maiga, Boubakar

AU - Elisabeth, Israelsson

AU - Ouédraogo, André Lin

AU - Bougouma, Edith C

AU - Diarra, Amidou

AU - Ouédraogo, Alphonse

AU - Ouattara, Aboubacar S

AU - Troye-Blomberg, Marita

AU - Dolo, Amagana

AU - Cavanagh, David R

AU - Theisen, Michael

AU - Modiano, David

AU - Sirima, Sodiomon B

AU - Nebié, Issa

PY - 2012/6

Y1 - 2012/6

N2 - FcγRIIa is known to be polymorphic; and certain variants are associated with different susceptibilities to malaria. Studies involving the Fulani ethnic group reported an ethnic difference in FcγRIIa-R131H genotype frequencies between the Fulani and other sympatric groups. No previous studies have addressed these questions in Burkina Faso. This study aimed to assess the influence of FcγRIIa-R131H polymorphism on anti-falciparum malaria IgG and IgG subclass responses in the Fulani and the Mossi ethnic groups living in Burkina Faso. Healthy adults more than 20years old belonging to the Mossi or the Fulani ethnic groups were enrolled for the assessment of selected parasitological, immunological and genetic variables in relation to their susceptibility to malaria. The prevalence of the Plasmodium falciparum infection frequency was relatively low in the Fulani ethnic group compared to the Mossi ethnic group. For all tested antigens, the Fulani had higher antibody levels than the Mossi group. In both ethnic groups, a similar distribution of FcγRIIa R131H polymorphism was found. Individuals with the R allele of FcγRIIa had higher antibody levels than those with the H allele. This study confirmed that malaria infection affected less the Fulani group than the Mossi group. FcγRIIa-R131H allele distribution is similar in both ethnic groups, and higher antibody levels are associated with the FcγRIIa R allele compared to the H allele.

AB - FcγRIIa is known to be polymorphic; and certain variants are associated with different susceptibilities to malaria. Studies involving the Fulani ethnic group reported an ethnic difference in FcγRIIa-R131H genotype frequencies between the Fulani and other sympatric groups. No previous studies have addressed these questions in Burkina Faso. This study aimed to assess the influence of FcγRIIa-R131H polymorphism on anti-falciparum malaria IgG and IgG subclass responses in the Fulani and the Mossi ethnic groups living in Burkina Faso. Healthy adults more than 20years old belonging to the Mossi or the Fulani ethnic groups were enrolled for the assessment of selected parasitological, immunological and genetic variables in relation to their susceptibility to malaria. The prevalence of the Plasmodium falciparum infection frequency was relatively low in the Fulani ethnic group compared to the Mossi ethnic group. For all tested antigens, the Fulani had higher antibody levels than the Mossi group. In both ethnic groups, a similar distribution of FcγRIIa R131H polymorphism was found. Individuals with the R allele of FcγRIIa had higher antibody levels than those with the H allele. This study confirmed that malaria infection affected less the Fulani group than the Mossi group. FcγRIIa-R131H allele distribution is similar in both ethnic groups, and higher antibody levels are associated with the FcγRIIa R allele compared to the H allele.

U2 - 10.1111/j.1365-3083.2012.02690.x

DO - 10.1111/j.1365-3083.2012.02690.x

M3 - Journal article

C2 - 22268665

SN - 0301-6323

VL - 75

SP - 606

EP - 613

JO - Scandinavian Journal of Immunology, Supplement

JF - Scandinavian Journal of Immunology, Supplement

IS - 6

ER -

FcGammaRIIa polymorphism and anti-malaria specific IgG and IgG subclass responses in populations differing in susceptibility to malaria in Burkina Faso

Abstract

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