Fc Gamma Receptor 3B (FCGR3Bc.233C>A-rs5030738)
Polymorphism Modifies the
Protective Effect of Malaria Specific
Antibodies in Ghanaian Children

Bright Adu; Micha Phill Grønholm Jepsen; Thomas A Gerds; Eric Kyei-Baafour; Michael Christiansen; Daniel Dodoo; Michael Theisen

doi:10.1093/infdis/jit422

Fc Gamma Receptor 3B (FCGR3Bc.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children

Bright Adu, Micha Phill Grønholm Jepsen, Thomas A Gerds, Eric Kyei-Baafour, Michael Christiansen, Daniel Dodoo, Michael Theisen

20 Citations (Scopus)

Abstract

Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.

Original language	English
Journal	The Journal of Infectious Diseases
Volume	209
Issue number	2
Pages (from-to)	285-9
Number of pages	5
ISSN	0022-1899
DOIs	https://doi.org/10.1093/infdis/jit422
Publication status	Published - 15 Jan 2014

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https://academic.oup.com/jid/article-pdf/209/2/285/13804204/jit422.pdf

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Fc Gamma Receptor 3B (FCGR3Bc.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children. / Adu, Bright; Jepsen, Micha Phill Grønholm; Gerds, Thomas A et al.
In: The Journal of Infectious Diseases, Vol. 209, No. 2, 15.01.2014, p. 285-9.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.",

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AU - Adu, Bright

AU - Jepsen, Micha Phill Grønholm

AU - Gerds, Thomas A

AU - Kyei-Baafour, Eric

AU - Christiansen, Michael

AU - Dodoo, Daniel

AU - Theisen, Michael

PY - 2014/1/15

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N2 - Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.

AB - Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.

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Fc Gamma Receptor 3B (FCGR3Bc.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children

Abstract

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