Fat oxidation at rest predicts peak fat oxidation during exercise and metabolic phenotype in overweight men

TY - JOUR

T1 - Fat oxidation at rest predicts peak fat oxidation during exercise and metabolic phenotype in overweight men

AU - Rosenkilde, M

AU - Nordby, P

AU - Nielsen, L B

AU - Stallknecht, B M

AU - Helge, J W

PY - 2010/5

Y1 - 2010/5

N2 - Objective:To elucidate if fat oxidation at rest predicts peak fat oxidation during exercise and/or metabolic phenotype in moderately overweight, sedentary men.Design:Cross-sectional study.Subjects:We measured respiratory exchange ratio (RER) at rest in 44 moderately overweight, normotensive and normoglycemic men and selected 8 subjects with a low RER (L-RER, body mass index (BMI): 27.9±0.9 kg m-2, RER: 0.76±0.02) and 8 with a high RER (H-RER; BMI 28.±11.1 kg m-2, RER: 0.89±0.02). After an overnight fast, a venous blood sample was obtained and a graded exercise test was performed. Fat oxidation during exercise was quantified using indirect calorimetry.Results:Peak fat oxidation during exercise was higher in L-RER than in H-RER (0.333±0.096 vs 0.169±0.028 g min-1; P<0.01) and occurred at a higher relative intensity (36.26.6 vs 28.23.1% VO2max, P<0.05). Using the International Diabetes Federation criteria, we found that there was a lower accumulation of metabolic risk factors in L-RER than in H-RER (1.6 vs 3.5, P=0.028), and no subjects in L-RER and four of eight subjects in H-RER had the metabolic syndrome. Resting RER was positively correlated with plasma triglycerides (P<0.01) and negatively with plasma free fatty acids (P<0.05), and peak fat oxidation during exercise was positively correlated with plasma free fatty acid concentration at rest (P<0.05).Conclusion:A low RER at rest predicts a high peak fat oxidation during exercise and a healthy metabolic phenotype in moderately overweight, sedentary men.

AB - Objective:To elucidate if fat oxidation at rest predicts peak fat oxidation during exercise and/or metabolic phenotype in moderately overweight, sedentary men.Design:Cross-sectional study.Subjects:We measured respiratory exchange ratio (RER) at rest in 44 moderately overweight, normotensive and normoglycemic men and selected 8 subjects with a low RER (L-RER, body mass index (BMI): 27.9±0.9 kg m-2, RER: 0.76±0.02) and 8 with a high RER (H-RER; BMI 28.±11.1 kg m-2, RER: 0.89±0.02). After an overnight fast, a venous blood sample was obtained and a graded exercise test was performed. Fat oxidation during exercise was quantified using indirect calorimetry.Results:Peak fat oxidation during exercise was higher in L-RER than in H-RER (0.333±0.096 vs 0.169±0.028 g min-1; P<0.01) and occurred at a higher relative intensity (36.26.6 vs 28.23.1% VO2max, P<0.05). Using the International Diabetes Federation criteria, we found that there was a lower accumulation of metabolic risk factors in L-RER than in H-RER (1.6 vs 3.5, P=0.028), and no subjects in L-RER and four of eight subjects in H-RER had the metabolic syndrome. Resting RER was positively correlated with plasma triglycerides (P<0.01) and negatively with plasma free fatty acids (P<0.05), and peak fat oxidation during exercise was positively correlated with plasma free fatty acid concentration at rest (P<0.05).Conclusion:A low RER at rest predicts a high peak fat oxidation during exercise and a healthy metabolic phenotype in moderately overweight, sedentary men.

U2 - 10.1038/ijo.2010.11

DO - 10.1038/ijo.2010.11

M3 - Journal article

C2 - 20157319

SN - 0307-0565

VL - 34

SP - 871

EP - 877

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 5

ER -