FAP finds FGF21 easy to digest

Matthew P Gillum; Matthew J Potthoff

doi:10.1042/BCJ20160004

FAP finds FGF21 easy to digest

Matthew P Gillum, Matthew J Potthoff

Department of Biomedical Sciences

4 Citations (Scopus)

Abstract

Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates carbohydrate and lipid metabolism. In humans, circulating FGF21 is inactivated by proteolytic cleavage of its C-terminus, thereby preventing signalling through a receptor complex. The mechanism for this cleavage event and the factors contributing to the post-translational regulation of FGF21 activity has previously been unknown. In a recent issue of the Biochemical Journal, Zhen et al. have identified fibroblast activation protein (FAP) as the endopeptidase responsible for this site-specific cleavage of human FGF21 (hFGF21), and propose that inhibition of FAP may be a therapeutic strategy to increase endogenous levels of active FGF21.

Original language	English
Journal	Biochemical Journal
Volume	473
Issue number	9
Pages (from-to)	1125-7
Number of pages	3
ISSN	0264-6021
DOIs	https://doi.org/10.1042/BCJ20160004
Publication status	Published - 1 May 2016

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10.1042/BCJ20160004

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title = "FAP finds FGF21 easy to digest",

abstract = "Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates carbohydrate and lipid metabolism. In humans, circulating FGF21 is inactivated by proteolytic cleavage of its C-terminus, thereby preventing signalling through a receptor complex. The mechanism for this cleavage event and the factors contributing to the post-translational regulation of FGF21 activity has previously been unknown. In a recent issue of the Biochemical Journal, Zhen et al. have identified fibroblast activation protein (FAP) as the endopeptidase responsible for this site-specific cleavage of human FGF21 (hFGF21), and propose that inhibition of FAP may be a therapeutic strategy to increase endogenous levels of active FGF21.",

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T1 - FAP finds FGF21 easy to digest

AU - Gillum, Matthew P

AU - Potthoff, Matthew J

PY - 2016/5/1

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N2 - Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates carbohydrate and lipid metabolism. In humans, circulating FGF21 is inactivated by proteolytic cleavage of its C-terminus, thereby preventing signalling through a receptor complex. The mechanism for this cleavage event and the factors contributing to the post-translational regulation of FGF21 activity has previously been unknown. In a recent issue of the Biochemical Journal, Zhen et al. have identified fibroblast activation protein (FAP) as the endopeptidase responsible for this site-specific cleavage of human FGF21 (hFGF21), and propose that inhibition of FAP may be a therapeutic strategy to increase endogenous levels of active FGF21.

AB - Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates carbohydrate and lipid metabolism. In humans, circulating FGF21 is inactivated by proteolytic cleavage of its C-terminus, thereby preventing signalling through a receptor complex. The mechanism for this cleavage event and the factors contributing to the post-translational regulation of FGF21 activity has previously been unknown. In a recent issue of the Biochemical Journal, Zhen et al. have identified fibroblast activation protein (FAP) as the endopeptidase responsible for this site-specific cleavage of human FGF21 (hFGF21), and propose that inhibition of FAP may be a therapeutic strategy to increase endogenous levels of active FGF21.

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U2 - 10.1042/BCJ20160004

DO - 10.1042/BCJ20160004

M3 - Comment/debate

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VL - 473

SP - 1125

EP - 1127

JO - Biochemical Journal

JF - Biochemical Journal

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FAP finds FGF21 easy to digest

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