Family history predicts major adverse cardiovascular events (MACE) in young adults with psoriasis

TY - JOUR

T1 - Family history predicts major adverse cardiovascular events (MACE) in young adults with psoriasis

AU - Egeberg, Alexander

AU - Bruun, Louise E

AU - Mallbris, Lotus

AU - Gislason, Gunnar H

AU - Skov, Lone

AU - Wu, Jashin J

AU - Hansen, Peter R

N1 - Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - BACKGROUND: Patients with psoriasis may have increased risk of major adverse cardiovascular (CV) events (MACE), and a family history of CV disease (CVD) is an independent risk factor for MACE.OBJECTIVE: We investigated the risk of first-time MACE in patients with psoriasis with or without a family history of CVD.METHODS: Between January 1, 1997, and December 31, 2011, we identified 2,722,375 individuals, including 25,774 and 4504 patients with mild and severe psoriasis, through administrative registers. Incidence rate ratios were estimated by Poisson regression.RESULTS: Mean baseline age was 26.6 (SD 8.6) years. A family history of CVD was found among 16,080 (62.4%) and 3009 (66.8%) patients with mild and severe psoriasis, respectively. In patients with psoriasis and a family history of CVD, the adjusted incidence rate ratios (95% CI) of MACE were 1.28 (1.12-1.46) and 1.62 (1.14-2.30) for mild and severe disease, respectively. In patients with psoriasis but without a family history of CVD, there was no increased risk of MACE.LIMITATIONS: Results may not apply to late-onset psoriasis.CONCLUSIONS: A family history of CVD predicted the risk of first-time MACE in young adults with psoriasis. The findings call for increased focus on a family history of CVD in CV risk assessment of patients with psoriasis.

AB - BACKGROUND: Patients with psoriasis may have increased risk of major adverse cardiovascular (CV) events (MACE), and a family history of CV disease (CVD) is an independent risk factor for MACE.OBJECTIVE: We investigated the risk of first-time MACE in patients with psoriasis with or without a family history of CVD.METHODS: Between January 1, 1997, and December 31, 2011, we identified 2,722,375 individuals, including 25,774 and 4504 patients with mild and severe psoriasis, through administrative registers. Incidence rate ratios were estimated by Poisson regression.RESULTS: Mean baseline age was 26.6 (SD 8.6) years. A family history of CVD was found among 16,080 (62.4%) and 3009 (66.8%) patients with mild and severe psoriasis, respectively. In patients with psoriasis and a family history of CVD, the adjusted incidence rate ratios (95% CI) of MACE were 1.28 (1.12-1.46) and 1.62 (1.14-2.30) for mild and severe disease, respectively. In patients with psoriasis but without a family history of CVD, there was no increased risk of MACE.LIMITATIONS: Results may not apply to late-onset psoriasis.CONCLUSIONS: A family history of CVD predicted the risk of first-time MACE in young adults with psoriasis. The findings call for increased focus on a family history of CVD in CV risk assessment of patients with psoriasis.

KW - Adult

KW - Cardiovascular Diseases

KW - Comorbidity

KW - Denmark

KW - Female

KW - Humans

KW - Incidence

KW - Male

KW - Poisson Distribution

KW - Psoriasis

KW - Registries

KW - Risk Factors

KW - Social Class

KW - Journal Article

U2 - 10.1016/j.jaad.2016.02.1227

DO - 10.1016/j.jaad.2016.02.1227

M3 - Journal article

C2 - 27283226

SN - 0190-9622

VL - 75

SP - 340

EP - 346

JO - American Academy of Dermatology. Journal

JF - American Academy of Dermatology. Journal

IS - 2

ER -