Familial occurrence of inflammatory bowel disease

M Orholm; P Munkholm; E Langholz; O H Nielsen; T I Sørensen; V Binder

doi:10.1056/NEJM199101103240203

Familial occurrence of inflammatory bowel disease

M Orholm, P Munkholm, E Langholz, O H Nielsen, T I Sørensen, V Binder

Department of Clinical Medicine

517 Citations (Scopus)

Abstract

BACKGROUND AND METHODS: We assessed the familial occurrence of inflammatory bowel disease in Copenhagen County, where there has been a long-term interest in the epidemiology of such disorders. In 1987 we interviewed 662 patients in whom inflammatory bowel disease had been diagnosed before 1979, asking whether their first- and second-degree relatives had this disorder. Ninety-six percent of the patients (504 with ulcerative colitis and 133 with Crohn's disease) provided adequate information.

RESULTS: As compared with the general population, the first-degree relatives of the 637 patients with ulcerative colitis or Crohn's disease had a 10-fold increase in the risk of having the same disease as the patients, after standardization for age and sex. The risk of having the other of the two diseases was also increased, but less so, and the increase in the risk of having Crohn's disease was not significant in the relatives of patients with ulcerative colitis. The risk of ulcerative colitis in first-degree relatives of patients with ulcerative colitis appeared to be virtually independent of the generation to which the first-degree relative belonged and of the sex of the patient and the relative. The risk of ulcerative colitis in first-degree relatives tended to be higher if the disease had been diagnosed in the patient before the age of 50, but the risk seemed to be independent of the current age of the relatives. The prevalence of the same disease as that of the patient (either ulcerative colitis or Crohn's disease) among second-degree relatives was increased; the prevalence of the other disease was not increased.

CONCLUSIONS: The 10-fold increase in the familial risk of ulcerative colitis and Crohn's disease strongly suggests that these disorders have a genetic cause.

Original language	English
Journal	New England Journal of Medicine
Volume	324
Issue number	2
Pages (from-to)	84-8
Number of pages	5
ISSN	0028-4793
DOIs	https://doi.org/10.1056/NEJM199101103240203
Publication status	Published - 10 Jan 1991

Keywords

Adult
Age Factors
Aged
Colitis, Ulcerative
Crohn Disease
Denmark
Female
Humans
Inflammatory Bowel Diseases
Male
Middle Aged
Prevalence
Probability
Risk
Sex Factors
Journal Article

Access to Document

10.1056/NEJM199101103240203

Cite this

@article{9c0bfd7dbd2c47fb9a61468512ff8453,

title = "Familial occurrence of inflammatory bowel disease",

abstract = "BACKGROUND AND METHODS: We assessed the familial occurrence of inflammatory bowel disease in Copenhagen County, where there has been a long-term interest in the epidemiology of such disorders. In 1987 we interviewed 662 patients in whom inflammatory bowel disease had been diagnosed before 1979, asking whether their first- and second-degree relatives had this disorder. Ninety-six percent of the patients (504 with ulcerative colitis and 133 with Crohn's disease) provided adequate information.RESULTS: As compared with the general population, the first-degree relatives of the 637 patients with ulcerative colitis or Crohn's disease had a 10-fold increase in the risk of having the same disease as the patients, after standardization for age and sex. The risk of having the other of the two diseases was also increased, but less so, and the increase in the risk of having Crohn's disease was not significant in the relatives of patients with ulcerative colitis. The risk of ulcerative colitis in first-degree relatives of patients with ulcerative colitis appeared to be virtually independent of the generation to which the first-degree relative belonged and of the sex of the patient and the relative. The risk of ulcerative colitis in first-degree relatives tended to be higher if the disease had been diagnosed in the patient before the age of 50, but the risk seemed to be independent of the current age of the relatives. The prevalence of the same disease as that of the patient (either ulcerative colitis or Crohn's disease) among second-degree relatives was increased; the prevalence of the other disease was not increased.CONCLUSIONS: The 10-fold increase in the familial risk of ulcerative colitis and Crohn's disease strongly suggests that these disorders have a genetic cause.",

keywords = "Adult, Age Factors, Aged, Colitis, Ulcerative, Crohn Disease, Denmark, Female, Humans, Inflammatory Bowel Diseases, Male, Middle Aged, Prevalence, Probability, Risk, Sex Factors, Journal Article",

author = "M Orholm and P Munkholm and E Langholz and Nielsen, {O H} and S{\o}rensen, {T I} and V Binder",

year = "1991",

month = jan,

day = "10",

doi = "10.1056/NEJM199101103240203",

language = "English",

volume = "324",

pages = "84--8",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachusetts Medical Society",

number = "2",

}

TY - JOUR

T1 - Familial occurrence of inflammatory bowel disease

AU - Orholm, M

AU - Munkholm, P

AU - Langholz, E

AU - Nielsen, O H

AU - Sørensen, T I

AU - Binder, V

PY - 1991/1/10

Y1 - 1991/1/10

N2 - BACKGROUND AND METHODS: We assessed the familial occurrence of inflammatory bowel disease in Copenhagen County, where there has been a long-term interest in the epidemiology of such disorders. In 1987 we interviewed 662 patients in whom inflammatory bowel disease had been diagnosed before 1979, asking whether their first- and second-degree relatives had this disorder. Ninety-six percent of the patients (504 with ulcerative colitis and 133 with Crohn's disease) provided adequate information.RESULTS: As compared with the general population, the first-degree relatives of the 637 patients with ulcerative colitis or Crohn's disease had a 10-fold increase in the risk of having the same disease as the patients, after standardization for age and sex. The risk of having the other of the two diseases was also increased, but less so, and the increase in the risk of having Crohn's disease was not significant in the relatives of patients with ulcerative colitis. The risk of ulcerative colitis in first-degree relatives of patients with ulcerative colitis appeared to be virtually independent of the generation to which the first-degree relative belonged and of the sex of the patient and the relative. The risk of ulcerative colitis in first-degree relatives tended to be higher if the disease had been diagnosed in the patient before the age of 50, but the risk seemed to be independent of the current age of the relatives. The prevalence of the same disease as that of the patient (either ulcerative colitis or Crohn's disease) among second-degree relatives was increased; the prevalence of the other disease was not increased.CONCLUSIONS: The 10-fold increase in the familial risk of ulcerative colitis and Crohn's disease strongly suggests that these disorders have a genetic cause.

AB - BACKGROUND AND METHODS: We assessed the familial occurrence of inflammatory bowel disease in Copenhagen County, where there has been a long-term interest in the epidemiology of such disorders. In 1987 we interviewed 662 patients in whom inflammatory bowel disease had been diagnosed before 1979, asking whether their first- and second-degree relatives had this disorder. Ninety-six percent of the patients (504 with ulcerative colitis and 133 with Crohn's disease) provided adequate information.RESULTS: As compared with the general population, the first-degree relatives of the 637 patients with ulcerative colitis or Crohn's disease had a 10-fold increase in the risk of having the same disease as the patients, after standardization for age and sex. The risk of having the other of the two diseases was also increased, but less so, and the increase in the risk of having Crohn's disease was not significant in the relatives of patients with ulcerative colitis. The risk of ulcerative colitis in first-degree relatives of patients with ulcerative colitis appeared to be virtually independent of the generation to which the first-degree relative belonged and of the sex of the patient and the relative. The risk of ulcerative colitis in first-degree relatives tended to be higher if the disease had been diagnosed in the patient before the age of 50, but the risk seemed to be independent of the current age of the relatives. The prevalence of the same disease as that of the patient (either ulcerative colitis or Crohn's disease) among second-degree relatives was increased; the prevalence of the other disease was not increased.CONCLUSIONS: The 10-fold increase in the familial risk of ulcerative colitis and Crohn's disease strongly suggests that these disorders have a genetic cause.

KW - Adult

KW - Age Factors

KW - Aged

KW - Colitis, Ulcerative

KW - Crohn Disease

KW - Denmark

KW - Female

KW - Humans

KW - Inflammatory Bowel Diseases

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Probability

KW - Risk

KW - Sex Factors

KW - Journal Article

U2 - 10.1056/NEJM199101103240203

DO - 10.1056/NEJM199101103240203

M3 - Journal article

C2 - 1984188

SN - 0028-4793

VL - 324

SP - 84

EP - 88

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 2

ER -

Familial occurrence of inflammatory bowel disease

Abstract

Keywords

Access to Document

Fingerprint

Cite this