Familial hypercholesterolaemia: cholesterol efflux and coronary disease

Jorie Versmissen; Ranitha Vongpromek; Reyhana Yahya; Jeroen B van der Net; Leonie van Vark-van der Zee; Jeannette Blommesteijn-Touw; Darcos Wattimena; Trinet Rietveld; Clive R Pullinger; Christina Christoffersen; Björn Dahlbäck; John P Kane; Monique Mulder; Eric J G Sijbrands

doi:10.1111/eci.12643

Familial hypercholesterolaemia: cholesterol efflux and coronary disease

Jorie Versmissen, Ranitha Vongpromek, Reyhana Yahya, Jeroen B van der Net, Leonie van Vark-van der Zee, Jeannette Blommesteijn-Touw, Darcos Wattimena, Trinet Rietveld, Clive R Pullinger, Christina Christoffersen, Björn Dahlbäck, John P Kane, Monique Mulder, Eric J G Sijbrands

Physiology of circulation, kidney and lung

16 Citations (Scopus)

Abstract

BACKGROUND: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux.

MATERIALS AND METHODS: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM).

RESULTS: Seven FH patients were asymptomatic and six had experienced a cardiac event at a mean age of 39 years. Compared to their non-FH brothers, cholesterol efflux from macrophages to plasma from the FH patients without CHD was 16 ± 22% (mean ± SD) higher and to plasma from the FH patients with CHD was 7 ± 8% lower (P = 0·03, CHD vs. non-CHD). Compared to their non-FH brothers, FH patients without CHD displayed significantly higher levels of HDL-cholesterol, HDL-S1P and apoM, while FH patients with CHD displayed lower levels than their non-FH brothers.

CONCLUSIONS: A higher plasma cholesterol efflux capacity and higher S1P and apoM content of HDL in asymptomatic FH patients may play a role in their apparent protection from premature CHD.

Original language	English
Journal	European Journal of Clinical Investigation
Volume	46
Issue number	7
Pages (from-to)	643-50
Number of pages	8
ISSN	0014-2972
DOIs	https://doi.org/10.1111/eci.12643
Publication status	Published - 1 Jul 2016

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Journal Article

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Versmissen, J., Vongpromek, R., Yahya, R., van der Net, J. B., van Vark-van der Zee, L., Blommesteijn-Touw, J., Wattimena, D., Rietveld, T., Pullinger, C. R., Christoffersen, C., Dahlbäck, B., Kane, J. P., Mulder, M., & Sijbrands, E. J. G. (2016). Familial hypercholesterolaemia: cholesterol efflux and coronary disease. European Journal of Clinical Investigation, 46(7), 643-50. https://doi.org/10.1111/eci.12643

Versmissen, J, Vongpromek, R, Yahya, R, van der Net, JB, van Vark-van der Zee, L, Blommesteijn-Touw, J, Wattimena, D, Rietveld, T, Pullinger, CR, Christoffersen, C, Dahlbäck, B, Kane, JP, Mulder, M & Sijbrands, EJG 2016, 'Familial hypercholesterolaemia: cholesterol efflux and coronary disease', European Journal of Clinical Investigation, vol. 46, no. 7, pp. 643-50. https://doi.org/10.1111/eci.12643

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title = "Familial hypercholesterolaemia: cholesterol efflux and coronary disease",

abstract = "BACKGROUND: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux.MATERIALS AND METHODS: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM).RESULTS: Seven FH patients were asymptomatic and six had experienced a cardiac event at a mean age of 39 years. Compared to their non-FH brothers, cholesterol efflux from macrophages to plasma from the FH patients without CHD was 16 ± 22% (mean ± SD) higher and to plasma from the FH patients with CHD was 7 ± 8% lower (P = 0·03, CHD vs. non-CHD). Compared to their non-FH brothers, FH patients without CHD displayed significantly higher levels of HDL-cholesterol, HDL-S1P and apoM, while FH patients with CHD displayed lower levels than their non-FH brothers.CONCLUSIONS: A higher plasma cholesterol efflux capacity and higher S1P and apoM content of HDL in asymptomatic FH patients may play a role in their apparent protection from premature CHD.",

keywords = "Journal Article",

author = "Jorie Versmissen and Ranitha Vongpromek and Reyhana Yahya and {van der Net}, {Jeroen B} and {van Vark-van der Zee}, Leonie and Jeannette Blommesteijn-Touw and Darcos Wattimena and Trinet Rietveld and Pullinger, {Clive R} and Christina Christoffersen and Bj{\"o}rn Dahlb{\"a}ck and Kane, {John P} and Monique Mulder and Sijbrands, {Eric J G}",

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year = "2016",

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doi = "10.1111/eci.12643",

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TY - JOUR

T1 - Familial hypercholesterolaemia

T2 - cholesterol efflux and coronary disease

AU - Versmissen, Jorie

AU - Vongpromek, Ranitha

AU - Yahya, Reyhana

AU - van der Net, Jeroen B

AU - van Vark-van der Zee, Leonie

AU - Blommesteijn-Touw, Jeannette

AU - Wattimena, Darcos

AU - Rietveld, Trinet

AU - Pullinger, Clive R

AU - Christoffersen, Christina

AU - Dahlbäck, Björn

AU - Kane, John P

AU - Mulder, Monique

AU - Sijbrands, Eric J G

PY - 2016/7/1

Y1 - 2016/7/1

N2 - BACKGROUND: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux.MATERIALS AND METHODS: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM).RESULTS: Seven FH patients were asymptomatic and six had experienced a cardiac event at a mean age of 39 years. Compared to their non-FH brothers, cholesterol efflux from macrophages to plasma from the FH patients without CHD was 16 ± 22% (mean ± SD) higher and to plasma from the FH patients with CHD was 7 ± 8% lower (P = 0·03, CHD vs. non-CHD). Compared to their non-FH brothers, FH patients without CHD displayed significantly higher levels of HDL-cholesterol, HDL-S1P and apoM, while FH patients with CHD displayed lower levels than their non-FH brothers.CONCLUSIONS: A higher plasma cholesterol efflux capacity and higher S1P and apoM content of HDL in asymptomatic FH patients may play a role in their apparent protection from premature CHD.

AB - BACKGROUND: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux.MATERIALS AND METHODS: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM).RESULTS: Seven FH patients were asymptomatic and six had experienced a cardiac event at a mean age of 39 years. Compared to their non-FH brothers, cholesterol efflux from macrophages to plasma from the FH patients without CHD was 16 ± 22% (mean ± SD) higher and to plasma from the FH patients with CHD was 7 ± 8% lower (P = 0·03, CHD vs. non-CHD). Compared to their non-FH brothers, FH patients without CHD displayed significantly higher levels of HDL-cholesterol, HDL-S1P and apoM, while FH patients with CHD displayed lower levels than their non-FH brothers.CONCLUSIONS: A higher plasma cholesterol efflux capacity and higher S1P and apoM content of HDL in asymptomatic FH patients may play a role in their apparent protection from premature CHD.

KW - Journal Article

U2 - 10.1111/eci.12643

DO - 10.1111/eci.12643

M3 - Journal article

C2 - 27208892

SN - 0014-2972

VL - 46

SP - 643

EP - 650

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

IS - 7

ER -

Familial hypercholesterolaemia: cholesterol efflux and coronary disease

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