TY - JOUR
T1 - Familial Clustering of Venous Thromboembolism
T2 - A Danish Nationwide Cohort Study
AU - Sindet-Pedersen, Caroline
AU - Oestergaard, Louise Bruun
AU - Gundlund, Anna
AU - Fosbøl, Emil Loldrup
AU - Aasbjerg, Kristian
AU - Pallisgaard, Jannik Langtved
AU - Gislason, Gunnar
AU - Torp-Pedersen, Christian
AU - Olesen, Jonas Bjerring
PY - 2016/12
Y1 - 2016/12
N2 - Background: Identification of risk factors for venous thromboembolism (VTE) is of utmost importance to improve current prophylactic regimes and treatment guidelines. The extent to which a family history contributes to the risk of VTE needs further exploration. Objectives: To examine the relative rate of VTE in first-degree relatives compared with the general population. Methods: By crosslinking Danish nationwide registries we identified patients with VTE between 1978 and 2012, and their familial relations. The first member in a family to acquire VTE was defined as the proband. All first-degree relatives to probands were followed from the VTE date of the proband and until an event (VTE), death, emigration, 100 year birthday or end of study: 31st of December 2012, whichever came first. The relative rate of VTE was estimated by standardized incidence ratios (SIR) using time-dependent Poisson regression models, with the general population as a fixed reference. Results: We identified 70,767 children of maternal probands, 66,065 children of paternal probands, and 29,183 siblings to sibling probands. Having a maternal proband or a paternal proband were associated with a significantly increased VTE rate of 2.15 (CI: 2.00-2.30) and 2.06 (CI: 1.92-2.21), respectively. The highest estimate of VTE was observed among siblings (adjusted SIR of 2.60 [CI: 2.38-2.83]). Noteworthy, the rate of VTE increased for all first-degree relatives when the proband was diagnosed with VTE in a young age (< 50 years). Conclusion: A family history of VTE was associated with a significantly increased rate of VTE among first-degree relatives compared with the general population.
AB - Background: Identification of risk factors for venous thromboembolism (VTE) is of utmost importance to improve current prophylactic regimes and treatment guidelines. The extent to which a family history contributes to the risk of VTE needs further exploration. Objectives: To examine the relative rate of VTE in first-degree relatives compared with the general population. Methods: By crosslinking Danish nationwide registries we identified patients with VTE between 1978 and 2012, and their familial relations. The first member in a family to acquire VTE was defined as the proband. All first-degree relatives to probands were followed from the VTE date of the proband and until an event (VTE), death, emigration, 100 year birthday or end of study: 31st of December 2012, whichever came first. The relative rate of VTE was estimated by standardized incidence ratios (SIR) using time-dependent Poisson regression models, with the general population as a fixed reference. Results: We identified 70,767 children of maternal probands, 66,065 children of paternal probands, and 29,183 siblings to sibling probands. Having a maternal proband or a paternal proband were associated with a significantly increased VTE rate of 2.15 (CI: 2.00-2.30) and 2.06 (CI: 1.92-2.21), respectively. The highest estimate of VTE was observed among siblings (adjusted SIR of 2.60 [CI: 2.38-2.83]). Noteworthy, the rate of VTE increased for all first-degree relatives when the proband was diagnosed with VTE in a young age (< 50 years). Conclusion: A family history of VTE was associated with a significantly increased rate of VTE among first-degree relatives compared with the general population.
U2 - 10.1371/journal.pone.0169055
DO - 10.1371/journal.pone.0169055
M3 - Journal article
C2 - 28033406
SN - 1932-6203
VL - 11
JO - PLoS Computational Biology
JF - PLoS Computational Biology
IS - 12
M1 - e0169055
ER -
