Familial clustering and subsequent incidence of atrial fibrillation among first-degree relatives in Denmark

Anna Gundlund; Mia N Christiansen; Morten Lock Hansen; Jonas Bjerring Olesen; Deewa Zahir; Lars Køber; Gunnar H Gislason; Jonathan P Piccini; Eric D Peterson; Christian Torp-Pedersen; Emil Loldrup Fosbøl

doi:10.1093/europace/euv274

Familial clustering and subsequent incidence of atrial fibrillation among first-degree relatives in Denmark

Anna Gundlund, Mia N Christiansen, Morten Lock Hansen, Jonas Bjerring Olesen, Deewa Zahir, Lars Køber, Gunnar H Gislason, Jonathan P Piccini, Eric D Peterson, Christian Torp-Pedersen, Emil Loldrup Fosbøl

Department of Clinical Medicine

12 Citations (Scopus)

Abstract

AIMS: Atrial fibrillation (AF) is associated with increased morbidity and mortality. Determination and quantification of familial risk may help identify high-risk patients.

METHODS AND RESULTS: Using Danish nationwide registry data (1978-2012), we identified all first-time AF patients (probands) in Denmark. Relatives to these probands were grouped according to proband-relation: offspring from either maternal or paternal proband, and siblings to proband. Age-specific incidence of AF for these three groups of relatives and for the general Danish population was estimated. Using the general population as reference, we calculated adjusted rate ratios (RRs) of AF in the three groups of relatives. We identified 67 310, 103 822, and 11 800 AF probands who were mothers (median age 74 years, IQR 66-81), fathers (70 years, IQR 62-78), and siblings (46 years, IQR 38-52), respectively. Among those, 133 516, 221 774, and 21 448 offspring from a maternal proband, offspring from a paternal proband, and siblings, respectively, were screened for incident AF. This was recorded in 2536 (1.9%), 2906 (1.3%), and 292 (1.4%) relatives, respectively. Compared with the general Danish population, the adjusted RRs for incident AF were 3.37 [95% confidence interval (CI) 3.21-3.53] for offspring from maternal probands, 2.81 (95% CI 2.69-2.93) for offspring from paternal probands, and 5.20 (95% CI 4.61-5.85) for siblings to sibling probands. Subgroup analyses showed increased RRs with younger aged probands.

CONCLUSION: Familial AF was associated with an increased RR of AF in first-degree relatives compared with the general Danish population. This suggests that familial AF is a major risk factor for developing AF in relatives.

Original language	English
Journal	Europace
Volume	18
Issue number	5
Pages (from-to)	658-64
Number of pages	7
ISSN	1099-5129
DOIs	https://doi.org/10.1093/europace/euv274
Publication status	Published - 24 May 2016

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Journal Article

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title = "Familial clustering and subsequent incidence of atrial fibrillation among first-degree relatives in Denmark",

abstract = "AIMS: Atrial fibrillation (AF) is associated with increased morbidity and mortality. Determination and quantification of familial risk may help identify high-risk patients.METHODS AND RESULTS: Using Danish nationwide registry data (1978-2012), we identified all first-time AF patients (probands) in Denmark. Relatives to these probands were grouped according to proband-relation: offspring from either maternal or paternal proband, and siblings to proband. Age-specific incidence of AF for these three groups of relatives and for the general Danish population was estimated. Using the general population as reference, we calculated adjusted rate ratios (RRs) of AF in the three groups of relatives. We identified 67 310, 103 822, and 11 800 AF probands who were mothers (median age 74 years, IQR 66-81), fathers (70 years, IQR 62-78), and siblings (46 years, IQR 38-52), respectively. Among those, 133 516, 221 774, and 21 448 offspring from a maternal proband, offspring from a paternal proband, and siblings, respectively, were screened for incident AF. This was recorded in 2536 (1.9%), 2906 (1.3%), and 292 (1.4%) relatives, respectively. Compared with the general Danish population, the adjusted RRs for incident AF were 3.37 [95% confidence interval (CI) 3.21-3.53] for offspring from maternal probands, 2.81 (95% CI 2.69-2.93) for offspring from paternal probands, and 5.20 (95% CI 4.61-5.85) for siblings to sibling probands. Subgroup analyses showed increased RRs with younger aged probands.CONCLUSION: Familial AF was associated with an increased RR of AF in first-degree relatives compared with the general Danish population. This suggests that familial AF is a major risk factor for developing AF in relatives.",

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author = "Anna Gundlund and Christiansen, {Mia N} and Hansen, {Morten Lock} and Olesen, {Jonas Bjerring} and Deewa Zahir and Lars K{\o}ber and Gislason, {Gunnar H} and Piccini, {Jonathan P} and Peterson, {Eric D} and Christian Torp-Pedersen and Fosb{\o}l, {Emil Loldrup}",

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doi = "10.1093/europace/euv274",

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TY - JOUR

T1 - Familial clustering and subsequent incidence of atrial fibrillation among first-degree relatives in Denmark

AU - Gundlund, Anna

AU - Christiansen, Mia N

AU - Hansen, Morten Lock

AU - Olesen, Jonas Bjerring

AU - Zahir, Deewa

AU - Køber, Lars

AU - Gislason, Gunnar H

AU - Piccini, Jonathan P

AU - Peterson, Eric D

AU - Torp-Pedersen, Christian

AU - Fosbøl, Emil Loldrup

PY - 2016/5/24

Y1 - 2016/5/24

N2 - AIMS: Atrial fibrillation (AF) is associated with increased morbidity and mortality. Determination and quantification of familial risk may help identify high-risk patients.METHODS AND RESULTS: Using Danish nationwide registry data (1978-2012), we identified all first-time AF patients (probands) in Denmark. Relatives to these probands were grouped according to proband-relation: offspring from either maternal or paternal proband, and siblings to proband. Age-specific incidence of AF for these three groups of relatives and for the general Danish population was estimated. Using the general population as reference, we calculated adjusted rate ratios (RRs) of AF in the three groups of relatives. We identified 67 310, 103 822, and 11 800 AF probands who were mothers (median age 74 years, IQR 66-81), fathers (70 years, IQR 62-78), and siblings (46 years, IQR 38-52), respectively. Among those, 133 516, 221 774, and 21 448 offspring from a maternal proband, offspring from a paternal proband, and siblings, respectively, were screened for incident AF. This was recorded in 2536 (1.9%), 2906 (1.3%), and 292 (1.4%) relatives, respectively. Compared with the general Danish population, the adjusted RRs for incident AF were 3.37 [95% confidence interval (CI) 3.21-3.53] for offspring from maternal probands, 2.81 (95% CI 2.69-2.93) for offspring from paternal probands, and 5.20 (95% CI 4.61-5.85) for siblings to sibling probands. Subgroup analyses showed increased RRs with younger aged probands.CONCLUSION: Familial AF was associated with an increased RR of AF in first-degree relatives compared with the general Danish population. This suggests that familial AF is a major risk factor for developing AF in relatives.

AB - AIMS: Atrial fibrillation (AF) is associated with increased morbidity and mortality. Determination and quantification of familial risk may help identify high-risk patients.METHODS AND RESULTS: Using Danish nationwide registry data (1978-2012), we identified all first-time AF patients (probands) in Denmark. Relatives to these probands were grouped according to proband-relation: offspring from either maternal or paternal proband, and siblings to proband. Age-specific incidence of AF for these three groups of relatives and for the general Danish population was estimated. Using the general population as reference, we calculated adjusted rate ratios (RRs) of AF in the three groups of relatives. We identified 67 310, 103 822, and 11 800 AF probands who were mothers (median age 74 years, IQR 66-81), fathers (70 years, IQR 62-78), and siblings (46 years, IQR 38-52), respectively. Among those, 133 516, 221 774, and 21 448 offspring from a maternal proband, offspring from a paternal proband, and siblings, respectively, were screened for incident AF. This was recorded in 2536 (1.9%), 2906 (1.3%), and 292 (1.4%) relatives, respectively. Compared with the general Danish population, the adjusted RRs for incident AF were 3.37 [95% confidence interval (CI) 3.21-3.53] for offspring from maternal probands, 2.81 (95% CI 2.69-2.93) for offspring from paternal probands, and 5.20 (95% CI 4.61-5.85) for siblings to sibling probands. Subgroup analyses showed increased RRs with younger aged probands.CONCLUSION: Familial AF was associated with an increased RR of AF in first-degree relatives compared with the general Danish population. This suggests that familial AF is a major risk factor for developing AF in relatives.

KW - Journal Article

U2 - 10.1093/europace/euv274

DO - 10.1093/europace/euv274

M3 - Journal article

C2 - 26559919

SN - 1099-5129

VL - 18

SP - 658

EP - 664

JO - Europace

JF - Europace

IS - 5

ER -

Familial clustering and subsequent incidence of atrial fibrillation among first-degree relatives in Denmark

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