Hofvind, S., Ponti, A., Patnick, J., Ascunce, N., Njor, S. H., Broeders, M., Giordano, L., Frigerio, A., Törnberg, S., Van Hal, G., Martens, P., Májek, O., Danes, J., von Euler-Chelpin, M., Aasmaa, A., Anttila, A., Becker, N., Péntek, Z., Budai, A., ... EUNICE Project and Euroscreen Working Groups (2012). False-positive results in mammographic screening for breast cancer in Europe: a literature review and survey of service screening programmes. Journal of Medical Screening, 19 Suppl 1, 57-66. https://doi.org/10.1258/jms.2012.012083
Hofvind, S, Ponti, A, Patnick, J, Ascunce, N, Njor, SH, Broeders, M, Giordano, L, Frigerio, A, Törnberg, S, Van Hal, G, Martens, P, Májek, O, Danes, J, von Euler-Chelpin, M, Aasmaa, A, Anttila, A, Becker, N, Péntek, Z, Budai, A, Mádai, S, Fitzpatrick, P, Mooney, T, Zappa, M, Ventura, L, Scharpantgen, A, Hofvind, S, Seroczynski, P, Morais, A, Rodrigues, V, Bento, MJ, Gomes de Carvalho, J, Natal, C, Prieto, M, Sánchez-Contador Escudero, C, Zubizarreta Alberti, R, Fernández Llanes, SB, Ascunce, N, Ederra Sanza, M, Sarriugarte Irigoien, G, Salas Trejo, D, Ibáñez Cabanell, J, Wiege, M, Ohlsson, G, Törnberg, S, Korzeniewska, M, de Wolf, C, Fracheboud, J, Patnick, J, Lancucki, L, Ducarroz, S & EUNICE Project and Euroscreen Working Groups 2012, 'False-positive results in mammographic screening for breast cancer in Europe: a literature review and survey of service screening programmes', Journal of Medical Screening, vol. 19 Suppl 1, pp. 57-66. https://doi.org/10.1258/jms.2012.012083
@article{9e307c69665344a9843882a82a6fe32b,
title = "False-positive results in mammographic screening for breast cancer in Europe: a literature review and survey of service screening programmes",
abstract = "Objective To estimate the cumulative risk of a false-positive screening result in European mammographic screening programmes, and examine the rates and procedures of further assessment. Methods A literature review was conducted to identify studies of the cumulative risk of a false-positive result in European screening programmes (390,000 women). We then examined aggregate data, cross-sectional information about further assessment procedures among women with positive results in 20 mammographic screening programmes from 17 countries (1.7 million initial screens, 5.9 million subsequent screens), collected by the European Network for Information on Cancer project (EUNICE). Results The estimated cumulative risk of a false-positive screening result in women aged 50-69 undergoing 10 biennial screening tests varied from 8% to 21% in the three studies examined (pooled estimate 19.7%). The cumulative risk of an invasive procedure with benign outcome ranged from 1.8% to 6.3% (pooled estimate 2.9%). The risk of undergoing surgical intervention with benign outcome was 0.9% (one study only). From the EUNICE project, the proportions of all screening examinations in the programmes resulting in needle biopsy were 2.2% and 1.1% for initial and subsequent screens, respectively, though the rates differed between countries; the corresponding rates of surgical interventions among women without breast cancer were 0.19% and 0.07%. Conclusion The specific investigative procedures following a recall should be considered when examining the cumulative risk of a false-positive screening result. Most women with a positive screening test undergo a non-invasive assessment procedure. Only a small proportion of recalled women undergo needle biopsy, and even fewer undergo surgical intervention.",
keywords = "Breast Neoplasms, False Positive Reactions, Female, Humans, Mammography, Mass Screening",
author = "Solveig Hofvind and Antonio Ponti and Julietta Patnick and Nieves Ascunce and Njor, {Sisse Helle} and Mireille Broeders and Livia Giordano and Alfonso Frigerio and Sven T{\"o}rnberg and {Van Hal}, G and P Martens and O M{\'a}jek and J Danes and {von Euler-Chelpin}, M and A Aasmaa and A Anttila and N Becker and Z P{\'e}ntek and A Budai and S M{\'a}dai and P Fitzpatrick and T Mooney and M Zappa and L Ventura and A Scharpantgen and S Hofvind and P Seroczynski and A Morais and V Rodrigues and Bento, {M J} and {Gomes de Carvalho}, J and C Natal and M Prieto and {S{\'a}nchez-Contador Escudero}, C and {Zubizarreta Alberti}, R and {Fern{\'a}ndez Llanes}, {S B} and N Ascunce and {Ederra Sanza}, M and {Sarriugarte Irigoien}, G and {Salas Trejo}, D and {Ib{\'a}{\~n}ez Cabanell}, J and M Wiege and G Ohlsson and S T{\"o}rnberg and M Korzeniewska and {de Wolf}, C and J Fracheboud and J Patnick and L Lancucki and S Ducarroz and {EUNICE Project and Euroscreen Working Groups}",
year = "2012",
month = sep,
doi = "10.1258/jms.2012.012083",
language = "English",
volume = "19 Suppl 1",
pages = "57--66",
journal = "Journal of Medical Screening",
issn = "1475-5793",
publisher = "SAGE Publications",
}
TY - JOUR
T1 - False-positive results in mammographic screening for breast cancer in Europe
T2 - a literature review and survey of service screening programmes
AU - Hofvind, Solveig
AU - Ponti, Antonio
AU - Patnick, Julietta
AU - Ascunce, Nieves
AU - Njor, Sisse Helle
AU - Broeders, Mireille
AU - Giordano, Livia
AU - Frigerio, Alfonso
AU - Törnberg, Sven
AU - Van Hal, G
AU - Martens, P
AU - Májek, O
AU - Danes, J
AU - von Euler-Chelpin, M
AU - Aasmaa, A
AU - Anttila, A
AU - Becker, N
AU - Péntek, Z
AU - Budai, A
AU - Mádai, S
AU - Fitzpatrick, P
AU - Mooney, T
AU - Zappa, M
AU - Ventura, L
AU - Scharpantgen, A
AU - Hofvind, S
AU - Seroczynski, P
AU - Morais, A
AU - Rodrigues, V
AU - Bento, M J
AU - Gomes de Carvalho, J
AU - Natal, C
AU - Prieto, M
AU - Sánchez-Contador Escudero, C
AU - Zubizarreta Alberti, R
AU - Fernández Llanes, S B
AU - Ascunce, N
AU - Ederra Sanza, M
AU - Sarriugarte Irigoien, G
AU - Salas Trejo, D
AU - Ibáñez Cabanell, J
AU - Wiege, M
AU - Ohlsson, G
AU - Törnberg, S
AU - Korzeniewska, M
AU - de Wolf, C
AU - Fracheboud, J
AU - Patnick, J
AU - Lancucki, L
AU - Ducarroz, S
AU - EUNICE Project and Euroscreen Working Groups
PY - 2012/9
Y1 - 2012/9
N2 - Objective To estimate the cumulative risk of a false-positive screening result in European mammographic screening programmes, and examine the rates and procedures of further assessment. Methods A literature review was conducted to identify studies of the cumulative risk of a false-positive result in European screening programmes (390,000 women). We then examined aggregate data, cross-sectional information about further assessment procedures among women with positive results in 20 mammographic screening programmes from 17 countries (1.7 million initial screens, 5.9 million subsequent screens), collected by the European Network for Information on Cancer project (EUNICE). Results The estimated cumulative risk of a false-positive screening result in women aged 50-69 undergoing 10 biennial screening tests varied from 8% to 21% in the three studies examined (pooled estimate 19.7%). The cumulative risk of an invasive procedure with benign outcome ranged from 1.8% to 6.3% (pooled estimate 2.9%). The risk of undergoing surgical intervention with benign outcome was 0.9% (one study only). From the EUNICE project, the proportions of all screening examinations in the programmes resulting in needle biopsy were 2.2% and 1.1% for initial and subsequent screens, respectively, though the rates differed between countries; the corresponding rates of surgical interventions among women without breast cancer were 0.19% and 0.07%. Conclusion The specific investigative procedures following a recall should be considered when examining the cumulative risk of a false-positive screening result. Most women with a positive screening test undergo a non-invasive assessment procedure. Only a small proportion of recalled women undergo needle biopsy, and even fewer undergo surgical intervention.
AB - Objective To estimate the cumulative risk of a false-positive screening result in European mammographic screening programmes, and examine the rates and procedures of further assessment. Methods A literature review was conducted to identify studies of the cumulative risk of a false-positive result in European screening programmes (390,000 women). We then examined aggregate data, cross-sectional information about further assessment procedures among women with positive results in 20 mammographic screening programmes from 17 countries (1.7 million initial screens, 5.9 million subsequent screens), collected by the European Network for Information on Cancer project (EUNICE). Results The estimated cumulative risk of a false-positive screening result in women aged 50-69 undergoing 10 biennial screening tests varied from 8% to 21% in the three studies examined (pooled estimate 19.7%). The cumulative risk of an invasive procedure with benign outcome ranged from 1.8% to 6.3% (pooled estimate 2.9%). The risk of undergoing surgical intervention with benign outcome was 0.9% (one study only). From the EUNICE project, the proportions of all screening examinations in the programmes resulting in needle biopsy were 2.2% and 1.1% for initial and subsequent screens, respectively, though the rates differed between countries; the corresponding rates of surgical interventions among women without breast cancer were 0.19% and 0.07%. Conclusion The specific investigative procedures following a recall should be considered when examining the cumulative risk of a false-positive screening result. Most women with a positive screening test undergo a non-invasive assessment procedure. Only a small proportion of recalled women undergo needle biopsy, and even fewer undergo surgical intervention.
KW - Breast Neoplasms
KW - False Positive Reactions
KW - Female
KW - Humans
KW - Mammography
KW - Mass Screening
U2 - 10.1258/jms.2012.012083
DO - 10.1258/jms.2012.012083
M3 - Journal article
C2 - 22972811
SN - 1475-5793
VL - 19 Suppl 1
SP - 57
EP - 66
JO - Journal of Medical Screening
JF - Journal of Medical Screening
ER -
