Factors of importance for a successful delivery system for proteins

Marco van de Weert; Lene Jorgensen; Eva Horn Moeller; Sven Frokjaer

doi:10.1517/17425247.2.6.1029

Factors of importance for a successful delivery system for proteins

Marco van de Weert, Lene Jorgensen, Eva Horn Moeller, Sven Frokjaer

35 Citations (Scopus)

Abstract

Protein pharmaceuticals have matured into an important class of drugs, now comprising one in three novel drugs introduced on the market. However, significant gains are still to be made in reducing the costs of production, ensuring proper pharmacokinetics and efficacy, increasing patient compliance and convenience, and reducing side effects such as immunogenicity. This review summarises these issues and provides recent examples of methods to reduce costs, alter pharmacokinetics and increase patient compliance. It also discusses the increasing interest in understanding immunogenicity in order to prevent failure of the protein drug or serious life-threatening side effects due to autoimmunogenicity.

Original language	English
Journal	Expert Opinion on Drug Delivery
Volume	2
Issue number	6
Pages (from-to)	1029-37
Number of pages	9
ISSN	1742-5247
DOIs	https://doi.org/10.1517/17425247.2.6.1029
Publication status	Published - Nov 2005

Keywords

Animals
Antibody Formation
Chemistry, Pharmaceutical
Drug Administration Routes
Drug Delivery Systems
Drug Stability
Erythropoietin
Humans
Patient Compliance
Proteins
Recombinant Proteins
Red-Cell Aplasia, Pure

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10.1517/17425247.2.6.1029

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title = "Factors of importance for a successful delivery system for proteins",

abstract = "Protein pharmaceuticals have matured into an important class of drugs, now comprising one in three novel drugs introduced on the market. However, significant gains are still to be made in reducing the costs of production, ensuring proper pharmacokinetics and efficacy, increasing patient compliance and convenience, and reducing side effects such as immunogenicity. This review summarises these issues and provides recent examples of methods to reduce costs, alter pharmacokinetics and increase patient compliance. It also discusses the increasing interest in understanding immunogenicity in order to prevent failure of the protein drug or serious life-threatening side effects due to autoimmunogenicity.",

keywords = "Animals, Antibody Formation, Chemistry, Pharmaceutical, Drug Administration Routes, Drug Delivery Systems, Drug Stability, Erythropoietin, Humans, Patient Compliance, Proteins, Recombinant Proteins, Red-Cell Aplasia, Pure",

author = "{van de Weert}, Marco and Lene Jorgensen and {Horn Moeller}, Eva and Sven Frokjaer",

year = "2005",

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language = "English",

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AU - van de Weert, Marco

AU - Jorgensen, Lene

AU - Horn Moeller, Eva

AU - Frokjaer, Sven

PY - 2005/11

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N2 - Protein pharmaceuticals have matured into an important class of drugs, now comprising one in three novel drugs introduced on the market. However, significant gains are still to be made in reducing the costs of production, ensuring proper pharmacokinetics and efficacy, increasing patient compliance and convenience, and reducing side effects such as immunogenicity. This review summarises these issues and provides recent examples of methods to reduce costs, alter pharmacokinetics and increase patient compliance. It also discusses the increasing interest in understanding immunogenicity in order to prevent failure of the protein drug or serious life-threatening side effects due to autoimmunogenicity.

AB - Protein pharmaceuticals have matured into an important class of drugs, now comprising one in three novel drugs introduced on the market. However, significant gains are still to be made in reducing the costs of production, ensuring proper pharmacokinetics and efficacy, increasing patient compliance and convenience, and reducing side effects such as immunogenicity. This review summarises these issues and provides recent examples of methods to reduce costs, alter pharmacokinetics and increase patient compliance. It also discusses the increasing interest in understanding immunogenicity in order to prevent failure of the protein drug or serious life-threatening side effects due to autoimmunogenicity.

KW - Animals

KW - Antibody Formation

KW - Chemistry, Pharmaceutical

KW - Drug Administration Routes

KW - Drug Delivery Systems

KW - Drug Stability

KW - Erythropoietin

KW - Humans

KW - Patient Compliance

KW - Proteins

KW - Recombinant Proteins

KW - Red-Cell Aplasia, Pure

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DO - 10.1517/17425247.2.6.1029

M3 - Review

C2 - 16296807

SN - 1742-5247

VL - 2

SP - 1029

EP - 1037

JO - Expert Opinion on Drug Delivery

JF - Expert Opinion on Drug Delivery

IS - 6

ER -

Factors of importance for a successful delivery system for proteins

Abstract

Keywords

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