TY - JOUR
T1 - Factors influencing serum total tryptase concentrations in a general adult population
AU - Gonzalez-Quintela, Arturo
AU - Vizcaino, Luis
AU - Gude, Francisco
AU - Rey, Jesus
AU - Meijide, Luis
AU - Fernandez-Merino, Carmen
AU - Linneberg, Allan
AU - Vidal, Carmen
PY - 2010/5/1
Y1 - 2010/5/1
N2 - Background: Serum tryptase measurements are increasingly being used in clinical practice. However, there is a paucity of studies focused on factors that influence tryptase concentrations. We investigated the relationships between total tryptase concentrations and age, gender, atopy, alcohol consumption, smoking, and common metabolic abnormalities in adults. Methods: This was a cross-sectional study of a random sample from an adult population (n=420, age 18-92 years, 45% males) from a single municipality. Serum total tryptase was measured using a fluoro-enzyme immunoassay. Results: The median tryptase concentration was 5.1 μg/L (range, <1-30.7 μg/L). There was a significant (p<0.0001) continual increase in tryptase with age; the median concentrations were 4.0 μg/L in 18-30 years old and 6.6 μg/L in those >80 years. Female gender and heavy ethanol use were negatively and independently associated with tryptase concentrations. Tryptase was higher in individuals that were non-atopic, overweight, or had metabolic syndrome compared to individuals that were atopic, normal weight, or did not have the metabolic syndrome. However, these associations were attenuated after adjusting for age. Conclusions: Serum total tryptase concentrations in adults are not significantly modified by atopy status, but may be modified by lifestyle factors, such as alcohol consumption and gender. Serum total tryptase concentrations are particularly dependent on age.
AB - Background: Serum tryptase measurements are increasingly being used in clinical practice. However, there is a paucity of studies focused on factors that influence tryptase concentrations. We investigated the relationships between total tryptase concentrations and age, gender, atopy, alcohol consumption, smoking, and common metabolic abnormalities in adults. Methods: This was a cross-sectional study of a random sample from an adult population (n=420, age 18-92 years, 45% males) from a single municipality. Serum total tryptase was measured using a fluoro-enzyme immunoassay. Results: The median tryptase concentration was 5.1 μg/L (range, <1-30.7 μg/L). There was a significant (p<0.0001) continual increase in tryptase with age; the median concentrations were 4.0 μg/L in 18-30 years old and 6.6 μg/L in those >80 years. Female gender and heavy ethanol use were negatively and independently associated with tryptase concentrations. Tryptase was higher in individuals that were non-atopic, overweight, or had metabolic syndrome compared to individuals that were atopic, normal weight, or did not have the metabolic syndrome. However, these associations were attenuated after adjusting for age. Conclusions: Serum total tryptase concentrations in adults are not significantly modified by atopy status, but may be modified by lifestyle factors, such as alcohol consumption and gender. Serum total tryptase concentrations are particularly dependent on age.
U2 - 10.1515/cclm.2010.124
DO - 10.1515/cclm.2010.124
M3 - Journal article
SN - 1434-6621
VL - 48
SP - 701
EP - 706
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
IS - 5
ER -