Extrastriatal dopamine D2/3 receptors and cortical grey matter volumes in antipsychotic-naïve schizophrenia patients before and after initial antipsychotic treatment

Henrik Nørbak-Emig; Lars Hageman Pinborg; Jayachandra Mitta Raghava; Claus Svarer; William Frans Christian Baaré; Peter Allerup; Lars Friberg; Egill Rostrup; Birte Yding Glenthøj; Bjørn Hylsebeck Ebdrup

doi:10.1080/15622975.2016.1237042

Extrastriatal dopamine D_2/3 receptors and cortical grey matter volumes in antipsychotic-naïve schizophrenia patients before and after initial antipsychotic treatment

Henrik Nørbak-Emig, Lars Hageman Pinborg, Jayachandra Mitta Raghava, Claus Svarer, William Frans Christian Baaré, Peter Allerup, Lars Friberg, Egill Rostrup, Birte Yding Glenthøj, Bjørn Hylsebeck Ebdrup

Department of Clinical Medicine

4 Citations (Scopus)

Abstract

OBJECTIVES: Long-term dopamine D2/3 receptor blockade, common to all antipsychotics, may underlie progressive brain volume changes observed in patients with chronic schizophrenia. In the present study, we examined associations between cortical volume changes and extrastriatal dopamine D2/3 receptor binding potentials (BPND) in first-episode schizophrenia patents at baseline and after antipsychotic treatment.

METHODS: Twenty-two initially antipsychotic-naïve patients underwent magnetic resonance imaging (MRI), [(123)I]epidepride single-photon emission computerised tomography (SPECT), and psychopathology assessments before and after 3 months of treatment with either risperidone (N = 13) or zuclopenthixol (N = 9). Twenty healthy controls matched on age, gender and parental socioeconomic status underwent baseline MRI and SPECT.

RESULTS: Neither extrastriatal D2/3 receptor BPND at baseline, nor blockade at follow-up, was related to regional cortical volume changes. In post-hoc analyses excluding three patients with cannabis use we found that higher D2/3 receptor occupancy was significantly associated with an increase in right frontal grey matter volume.

CONCLUSIONS: The present data do not support an association between extrastriatal D2/3 receptor blockade and extrastriatal grey matter loss in the early phases of schizophrenia. Although inconclusive, our exclusion of patients tested positive for cannabis use speaks to keeping attention to potential confounding factors in imaging studies.

Original language	English
Journal	World Journal of Biological Psychiatry
Volume	18
Issue number	7
Pages (from-to)	539-549
Number of pages	11
ISSN	1562-2975
DOIs	https://doi.org/10.1080/15622975.2016.1237042
Publication status	Published - 3 Oct 2017

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Journal Article

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10.1080/15622975.2016.1237042

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Nørbak-Emig, H., Pinborg, L. H., Raghava, J. M., Svarer, C., Baaré, W. F. C., Allerup, P., Friberg, L., Rostrup, E., Glenthøj, B. Y., & Ebdrup, B. H. (2017). Extrastriatal dopamine D_2/3 receptors and cortical grey matter volumes in antipsychotic-naïve schizophrenia patients before and after initial antipsychotic treatment. World Journal of Biological Psychiatry, 18(7), 539-549. https://doi.org/10.1080/15622975.2016.1237042

Extrastriatal dopamine D_2/3 receptors and cortical grey matter volumes in antipsychotic-naïve schizophrenia patients before and after initial antipsychotic treatment. / Nørbak-Emig, Henrik; Pinborg, Lars Hageman; Raghava, Jayachandra Mitta et al.

In: World Journal of Biological Psychiatry, Vol. 18, No. 7, 03.10.2017, p. 539-549.

Research output: Contribution to journal › Journal article › Research › peer-review

Nørbak-Emig, H, Pinborg, LH, Raghava, JM, Svarer, C, Baaré, WFC, Allerup, P, Friberg, L, Rostrup, E, Glenthøj, BY & Ebdrup, BH 2017, 'Extrastriatal dopamine D_2/3 receptors and cortical grey matter volumes in antipsychotic-naïve schizophrenia patients before and after initial antipsychotic treatment', World Journal of Biological Psychiatry, vol. 18, no. 7, pp. 539-549. https://doi.org/10.1080/15622975.2016.1237042

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abstract = "OBJECTIVES: Long-term dopamine D2/3 receptor blockade, common to all antipsychotics, may underlie progressive brain volume changes observed in patients with chronic schizophrenia. In the present study, we examined associations between cortical volume changes and extrastriatal dopamine D2/3 receptor binding potentials (BPND) in first-episode schizophrenia patents at baseline and after antipsychotic treatment.METHODS: Twenty-two initially antipsychotic-na{\"i}ve patients underwent magnetic resonance imaging (MRI), [(123)I]epidepride single-photon emission computerised tomography (SPECT), and psychopathology assessments before and after 3 months of treatment with either risperidone (N = 13) or zuclopenthixol (N = 9). Twenty healthy controls matched on age, gender and parental socioeconomic status underwent baseline MRI and SPECT.RESULTS: Neither extrastriatal D2/3 receptor BPND at baseline, nor blockade at follow-up, was related to regional cortical volume changes. In post-hoc analyses excluding three patients with cannabis use we found that higher D2/3 receptor occupancy was significantly associated with an increase in right frontal grey matter volume.CONCLUSIONS: The present data do not support an association between extrastriatal D2/3 receptor blockade and extrastriatal grey matter loss in the early phases of schizophrenia. Although inconclusive, our exclusion of patients tested positive for cannabis use speaks to keeping attention to potential confounding factors in imaging studies.",

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AU - Nørbak-Emig, Henrik

AU - Pinborg, Lars Hageman

AU - Raghava, Jayachandra Mitta

AU - Svarer, Claus

AU - Baaré, William Frans Christian

AU - Allerup, Peter

AU - Friberg, Lars

AU - Rostrup, Egill

AU - Glenthøj, Birte Yding

AU - Ebdrup, Bjørn Hylsebeck

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N2 - OBJECTIVES: Long-term dopamine D2/3 receptor blockade, common to all antipsychotics, may underlie progressive brain volume changes observed in patients with chronic schizophrenia. In the present study, we examined associations between cortical volume changes and extrastriatal dopamine D2/3 receptor binding potentials (BPND) in first-episode schizophrenia patents at baseline and after antipsychotic treatment.METHODS: Twenty-two initially antipsychotic-naïve patients underwent magnetic resonance imaging (MRI), [(123)I]epidepride single-photon emission computerised tomography (SPECT), and psychopathology assessments before and after 3 months of treatment with either risperidone (N = 13) or zuclopenthixol (N = 9). Twenty healthy controls matched on age, gender and parental socioeconomic status underwent baseline MRI and SPECT.RESULTS: Neither extrastriatal D2/3 receptor BPND at baseline, nor blockade at follow-up, was related to regional cortical volume changes. In post-hoc analyses excluding three patients with cannabis use we found that higher D2/3 receptor occupancy was significantly associated with an increase in right frontal grey matter volume.CONCLUSIONS: The present data do not support an association between extrastriatal D2/3 receptor blockade and extrastriatal grey matter loss in the early phases of schizophrenia. Although inconclusive, our exclusion of patients tested positive for cannabis use speaks to keeping attention to potential confounding factors in imaging studies.

AB - OBJECTIVES: Long-term dopamine D2/3 receptor blockade, common to all antipsychotics, may underlie progressive brain volume changes observed in patients with chronic schizophrenia. In the present study, we examined associations between cortical volume changes and extrastriatal dopamine D2/3 receptor binding potentials (BPND) in first-episode schizophrenia patents at baseline and after antipsychotic treatment.METHODS: Twenty-two initially antipsychotic-naïve patients underwent magnetic resonance imaging (MRI), [(123)I]epidepride single-photon emission computerised tomography (SPECT), and psychopathology assessments before and after 3 months of treatment with either risperidone (N = 13) or zuclopenthixol (N = 9). Twenty healthy controls matched on age, gender and parental socioeconomic status underwent baseline MRI and SPECT.RESULTS: Neither extrastriatal D2/3 receptor BPND at baseline, nor blockade at follow-up, was related to regional cortical volume changes. In post-hoc analyses excluding three patients with cannabis use we found that higher D2/3 receptor occupancy was significantly associated with an increase in right frontal grey matter volume.CONCLUSIONS: The present data do not support an association between extrastriatal D2/3 receptor blockade and extrastriatal grey matter loss in the early phases of schizophrenia. Although inconclusive, our exclusion of patients tested positive for cannabis use speaks to keeping attention to potential confounding factors in imaging studies.

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