Expression of filaggrin in normal and keratinized conjunctiva

Anne Sofie Kragegaard Lund; Steffen Heegaard; Jan Ulrik Prause; Peter Bjerre Toft; Lone Skov

doi:10.2174/1874364101206010137

Expression of filaggrin in normal and keratinized conjunctiva

Anne Sofie Kragegaard Lund, Steffen Heegaard, Jan Ulrik Prause, Peter Bjerre Toft, Lone Skov

2 Citations (Scopus)

Abstract

Purpose: We wanted to investigate filaggrin expression in normal conjunctiva and in conjunctiva exposed to different degrees of mechanical stress. Mechanical stress results in parakeratinization of the conjunctiva. If filaggrin is expressed in the milder forms of parakeratinization, it might be used as a sensitive marker of mechanical stress. Methods: Immunohistochemical staining using antibodies to filaggrin was performed on paraffin sections of normal human conjunctiva, and on conjunctiva with different degrees of mechanical conjunctival stress. Results: Filaggrin was not expressed in the normal conjunctiva, nor in conjunctiva with milder forms of mechanical stress. Intense staining of filaggrin was seen in the conjunctiva of a patient with Stevens-Johnson syndrome, and marked expression of filaggrin was found in the conjunctival epithelium of a patient with moderate dysplasia of the conjunctiva. Conclusion: Filaggrin is not a sensitive marker of mechanical stress; it is, however, expressed in some moderate and severe forms of parakeratinization of the conjunctiva.

Original language	English
Journal	The Open Ophthalmology Journal
Volume	6
Pages (from-to)	137-40
Number of pages	4
ISSN	1874-3641
DOIs	https://doi.org/10.2174/1874364101206010137
Publication status	Published - 2012

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title = "Expression of filaggrin in normal and keratinized conjunctiva",

abstract = "Purpose: We wanted to investigate filaggrin expression in normal conjunctiva and in conjunctiva exposed to different degrees of mechanical stress. Mechanical stress results in parakeratinization of the conjunctiva. If filaggrin is expressed in the milder forms of parakeratinization, it might be used as a sensitive marker of mechanical stress. Methods: Immunohistochemical staining using antibodies to filaggrin was performed on paraffin sections of normal human conjunctiva, and on conjunctiva with different degrees of mechanical conjunctival stress. Results: Filaggrin was not expressed in the normal conjunctiva, nor in conjunctiva with milder forms of mechanical stress. Intense staining of filaggrin was seen in the conjunctiva of a patient with Stevens-Johnson syndrome, and marked expression of filaggrin was found in the conjunctival epithelium of a patient with moderate dysplasia of the conjunctiva. Conclusion: Filaggrin is not a sensitive marker of mechanical stress; it is, however, expressed in some moderate and severe forms of parakeratinization of the conjunctiva.",

author = "Lund, {Anne Sofie Kragegaard} and Steffen Heegaard and Prause, {Jan Ulrik} and Toft, {Peter Bjerre} and Lone Skov",

year = "2012",

doi = "10.2174/1874364101206010137",

language = "English",

volume = "6",

pages = "137--40",

journal = "The Open Ophthalmology Journal",

issn = "1874-3641",

publisher = "Bentham Open",

}

TY - JOUR

T1 - Expression of filaggrin in normal and keratinized conjunctiva

AU - Lund, Anne Sofie Kragegaard

AU - Heegaard, Steffen

AU - Prause, Jan Ulrik

AU - Toft, Peter Bjerre

AU - Skov, Lone

PY - 2012

Y1 - 2012

N2 - Purpose: We wanted to investigate filaggrin expression in normal conjunctiva and in conjunctiva exposed to different degrees of mechanical stress. Mechanical stress results in parakeratinization of the conjunctiva. If filaggrin is expressed in the milder forms of parakeratinization, it might be used as a sensitive marker of mechanical stress. Methods: Immunohistochemical staining using antibodies to filaggrin was performed on paraffin sections of normal human conjunctiva, and on conjunctiva with different degrees of mechanical conjunctival stress. Results: Filaggrin was not expressed in the normal conjunctiva, nor in conjunctiva with milder forms of mechanical stress. Intense staining of filaggrin was seen in the conjunctiva of a patient with Stevens-Johnson syndrome, and marked expression of filaggrin was found in the conjunctival epithelium of a patient with moderate dysplasia of the conjunctiva. Conclusion: Filaggrin is not a sensitive marker of mechanical stress; it is, however, expressed in some moderate and severe forms of parakeratinization of the conjunctiva.

AB - Purpose: We wanted to investigate filaggrin expression in normal conjunctiva and in conjunctiva exposed to different degrees of mechanical stress. Mechanical stress results in parakeratinization of the conjunctiva. If filaggrin is expressed in the milder forms of parakeratinization, it might be used as a sensitive marker of mechanical stress. Methods: Immunohistochemical staining using antibodies to filaggrin was performed on paraffin sections of normal human conjunctiva, and on conjunctiva with different degrees of mechanical conjunctival stress. Results: Filaggrin was not expressed in the normal conjunctiva, nor in conjunctiva with milder forms of mechanical stress. Intense staining of filaggrin was seen in the conjunctiva of a patient with Stevens-Johnson syndrome, and marked expression of filaggrin was found in the conjunctival epithelium of a patient with moderate dysplasia of the conjunctiva. Conclusion: Filaggrin is not a sensitive marker of mechanical stress; it is, however, expressed in some moderate and severe forms of parakeratinization of the conjunctiva.

U2 - 10.2174/1874364101206010137

DO - 10.2174/1874364101206010137

M3 - Journal article

C2 - 23304250

SN - 1874-3641

VL - 6

SP - 137

EP - 140

JO - The Open Ophthalmology Journal

JF - The Open Ophthalmology Journal

ER -

Expression of filaggrin in normal and keratinized conjunctiva

Abstract

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