TY - JOUR
T1 - Expression of Circadian Clock Genes in Human Colorectal Cancer Tissues Using Droplet Digital PCR
AU - Orhan, Tugba
AU - Nielsen, Peter Böhm
AU - Hviid, Thomas Vauvert F
AU - Rosen, Andreas Weinberger
AU - Gögenür, Ismail
PY - 2019/2/7
Y1 - 2019/2/7
N2 - Increasing evidence indicates that disruption of circadian rhythms may be directly linked to cancer. Here we report that the expression levels of the core clock genes Per1 and Per3 measured by droplet digital polymerase chain reaction are significantly decreased in tumour tissue from 16 patients undergoing colorectal cancer surgery compared to paired normal mucosa. No differences were observed in the expression of Per2, Bmal1, and Clock. In conclusion, abnormal expression levels of the clock genes Per1 and Per3 in CRC tissue may be related to tumourigenesis and may provide future diagnostic and prognostic information.
AB - Increasing evidence indicates that disruption of circadian rhythms may be directly linked to cancer. Here we report that the expression levels of the core clock genes Per1 and Per3 measured by droplet digital polymerase chain reaction are significantly decreased in tumour tissue from 16 patients undergoing colorectal cancer surgery compared to paired normal mucosa. No differences were observed in the expression of Per2, Bmal1, and Clock. In conclusion, abnormal expression levels of the clock genes Per1 and Per3 in CRC tissue may be related to tumourigenesis and may provide future diagnostic and prognostic information.
U2 - 10.1080/07357907.2019.1571079
DO - 10.1080/07357907.2019.1571079
M3 - Journal article
C2 - 30732490
SN - 0735-7907
SP - 1
EP - 9
JO - Cancer Investigation
JF - Cancer Investigation
ER -
