Exercise training and work task induced metabolic and stress-related mRNA and protein responses in myalgic muscles

TY - JOUR

T1 - Exercise training and work task induced metabolic and stress-related mRNA and protein responses in myalgic muscles

AU - Sjøgaard, Gisela

AU - Zebis, Mette Kreutzfeldt

AU - Kiilerich, Kristian

AU - Saltin, Bengt

AU - Pilegaard, Henriette

PY - 2013

Y1 - 2013

N2 - The aim was to assess mRNA and/or protein levels of heat shock proteins, cytokines, growth regulating, and metabolic proteins in myalgic muscle at rest and in response to work tasks and prolonged exercise training. A randomized controlled trial included 28 females with trapezius myalgia and 16 healthy controls. Those with myalgia performed 7 hrs repetitive stressful work and were subsequently randomized to 10 weeks of specific strength training, general fitness training, or reference intervention. Muscles biopsies were taken from the trapezius muscle at baseline, after work and after 10 weeks intervention. The main findings are that the capacity of carbohydrate oxidation was reduced in myalgic compared with healthy muscle. Repetitive stressful work increased mRNA content for heat shock proteins and decreased levels of key regulators for growth and oxidative metabolism. In contrast, prolonged general fitness as well as specific strength training decreased mRNA content of heat shock protein while the capacity of carbohydrate oxidation was increased only after specific strength training.

AB - The aim was to assess mRNA and/or protein levels of heat shock proteins, cytokines, growth regulating, and metabolic proteins in myalgic muscle at rest and in response to work tasks and prolonged exercise training. A randomized controlled trial included 28 females with trapezius myalgia and 16 healthy controls. Those with myalgia performed 7 hrs repetitive stressful work and were subsequently randomized to 10 weeks of specific strength training, general fitness training, or reference intervention. Muscles biopsies were taken from the trapezius muscle at baseline, after work and after 10 weeks intervention. The main findings are that the capacity of carbohydrate oxidation was reduced in myalgic compared with healthy muscle. Repetitive stressful work increased mRNA content for heat shock proteins and decreased levels of key regulators for growth and oxidative metabolism. In contrast, prolonged general fitness as well as specific strength training decreased mRNA content of heat shock protein while the capacity of carbohydrate oxidation was increased only after specific strength training.

U2 - 10.1155/2013/984523

DO - 10.1155/2013/984523

M3 - Journal article

C2 - 23509827

SN - 1110-7243

VL - 2013

JO - Journal of Biomedicine and Biotechnology

JF - Journal of Biomedicine and Biotechnology

M1 - 984523

ER -