TY - JOUR
T1 - Exercise-induced regulation of matrix metalloproteinases in the skeletal muscle of subjects with type 2 diabetes
AU - Scheede-Bergdahl, Celena
AU - Bergdahl, Andreas
AU - Schjerling, Peter
AU - Qvortrup, Klaus
AU - Koskinen, Satu O
AU - Dela, Flemming
N1 - © The Author(s) 2014.
PY - 2014/9
Y1 - 2014/9
N2 - Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMP) play a critical role during vascular remodelling, in both health and disease. Impaired MMP regulation is associated with many diabetes-related complications. This study examined whether exercise-induced regulation of MMPs is maintained in the skeletal muscle of patients with uncomplicated type 2 diabetes (T2DM). Subjects [12 T2DM, 9 healthy control subjects (CON)] underwent 8 weeks of physical training. Messenger RNA (mRNA) was measured at baseline, during and after 8 weeks of training. Protein was measured pre- and post-training. At baseline, there were no effects of diabetes on MMP or TIMP mRNA or protein. mRNA and protein response to training was similar in both groups, except active MMP-2 protein was elevated post training in T2DM only. Our results indicate that exercise-induced stimulation of MMPs is preserved in skeletal muscle of patients with T2DM. This early stage of diabetes may provide an opportunity for intervention and prevention of complications.
AB - Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMP) play a critical role during vascular remodelling, in both health and disease. Impaired MMP regulation is associated with many diabetes-related complications. This study examined whether exercise-induced regulation of MMPs is maintained in the skeletal muscle of patients with uncomplicated type 2 diabetes (T2DM). Subjects [12 T2DM, 9 healthy control subjects (CON)] underwent 8 weeks of physical training. Messenger RNA (mRNA) was measured at baseline, during and after 8 weeks of training. Protein was measured pre- and post-training. At baseline, there were no effects of diabetes on MMP or TIMP mRNA or protein. mRNA and protein response to training was similar in both groups, except active MMP-2 protein was elevated post training in T2DM only. Our results indicate that exercise-induced stimulation of MMPs is preserved in skeletal muscle of patients with T2DM. This early stage of diabetes may provide an opportunity for intervention and prevention of complications.
U2 - 10.1177/1479164114535943
DO - 10.1177/1479164114535943
M3 - Journal article
C2 - 24903024
SN - 1479-1641
VL - 11
SP - 324
EP - 334
JO - Diabetes and Vascular Disease Research
JF - Diabetes and Vascular Disease Research
IS - 5
ER -
