TY - JOUR
T1 - Exercise-induced AMPK activity in skeletal muscle
T2 - Role in glucose uptake and insulin sensitivity
AU - Friedrichsen, Martin
AU - Mortensen, Brynjulf
AU - Pehmøller, Christian
AU - Birk, Jesper Bratz
AU - Wojtaszewski, Jørgen
N1 - CURIS 2013 NEXS 024
PY - 2013/2/25
Y1 - 2013/2/25
N2 - The energy/fuel sensor 5'-AMP-activated protein kinase (AMPK) is viewed as a master regulator of cellular energy balance due to its many roles in glucose, lipid, and protein metabolism. In this review we focus on the regulation of AMPK activity in skeletal muscle and its involvement in glucose metabolism, including glucose transport and glycogen synthesis. In addition, we discuss the plausible interplay between AMPK and insulin signaling regulating these processes.
AB - The energy/fuel sensor 5'-AMP-activated protein kinase (AMPK) is viewed as a master regulator of cellular energy balance due to its many roles in glucose, lipid, and protein metabolism. In this review we focus on the regulation of AMPK activity in skeletal muscle and its involvement in glucose metabolism, including glucose transport and glycogen synthesis. In addition, we discuss the plausible interplay between AMPK and insulin signaling regulating these processes.
U2 - 10.1016/j.mce.2012.06.013
DO - 10.1016/j.mce.2012.06.013
M3 - Review
C2 - 22796442
SN - 0303-7207
VL - 366
SP - 204
EP - 214
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
IS - 2
ER -