Executive dysfunction correlates with caudate nucleus atrophy in patients with white matter changes on MRI: A subset of LADIS

Matthew Duncan Macfarlane; Jeffrey Chee Leong Looi; Mark Walterfang; Gabriela Spulber; Dennis Velakoulis; Milita Crisby; Eva Orndahl; Timo Erkinjuntti; Ellen Garde; Gunhild Waldemar; Anders Wallin; Lars-Olof Wahlund; LADIS Study Group

doi:10.1016/j.pscychresns.2013.05.010

Executive dysfunction correlates with caudate nucleus atrophy in patients with white matter changes on MRI: A subset of LADIS

Matthew Duncan Macfarlane, Jeffrey Chee Leong Looi, Mark Walterfang, Gabriela Spulber, Dennis Velakoulis, Milita Crisby, Eva Orndahl, Timo Erkinjuntti, Ellen Garde, Gunhild Waldemar, Anders Wallin, Lars-Olof Wahlund, LADIS Study Group

Department of Clinical Medicine

20 Citations (Scopus)

Abstract

White matter changes (WMC) are common magnetic resonance imaging (MRI) findings, particularly in the elderly. Recent studies such as the Leukoaraiosis and Disability Study (LADIS) have found that WMC relate to adverse outcomes including cognitive impairment, depression, disability, unsteadiness and falls in cross-sectional and follow-up studies. Frontostriatal (or frontosubcortical) brain circuits may serve many of these functions, with the caudate nuclei playing a role in convergence of cognitive functions. This study aimed to determine whether reduced caudate volume relates to cognitive functions (executive functions, memory functions and speed of processing) and WMC. We determined caudate nuclei volumes, through manual tracing, on a subgroup of the LADIS study ( n=66) from four centres with baseline and 3-year follow-up MRI scans. Regression analysis was used to assess relationships between caudate volume, cognitive function and WMC. Severity of WMC did not relate to caudate volume. Smaller caudate volumes were significantly associated with poorer executive functioning at baseline and at 3 years, but were not associated with scores of memory or speed of processing. Thus, in patients with WMC, a surrogate of small vessel disease, caudate atrophy relates to the dysexecutive syndrome, supporting the role of caudate as an important part of the frontostriatal circuit.

Original language	English
Journal	Psychiatry Research: Neuroimaging
Volume	214
Issue number	1
Pages (from-to)	16-23
Number of pages	8
ISSN	0925-4927
DOIs	https://doi.org/10.1016/j.pscychresns.2013.05.010
Publication status	Published - 30 Oct 2013

Access to Document

10.1016/j.pscychresns.2013.05.010

Cite this

Macfarlane, M. D., Looi, J. C. L., Walterfang, M., Spulber, G., Velakoulis, D., Crisby, M., Orndahl, E., Erkinjuntti, T., Garde, E., Waldemar, G., Wallin, A., Wahlund, L-O., & Group, LADIS. S. (2013). Executive dysfunction correlates with caudate nucleus atrophy in patients with white matter changes on MRI: A subset of LADIS. Psychiatry Research: Neuroimaging, 214(1), 16-23. https://doi.org/10.1016/j.pscychresns.2013.05.010

Executive dysfunction correlates with caudate nucleus atrophy in patients with white matter changes on MRI: A subset of LADIS. / Macfarlane, Matthew Duncan; Looi, Jeffrey Chee Leong; Walterfang, Mark et al.

In: Psychiatry Research: Neuroimaging, Vol. 214, No. 1, 30.10.2013, p. 16-23.

Research output: Contribution to journal › Journal article › Research › peer-review

Macfarlane, MD, Looi, JCL, Walterfang, M, Spulber, G, Velakoulis, D, Crisby, M, Orndahl, E, Erkinjuntti, T, Garde, E , Waldemar, G, Wallin, A, Wahlund, L-O & Group, LADISS 2013, 'Executive dysfunction correlates with caudate nucleus atrophy in patients with white matter changes on MRI: A subset of LADIS', Psychiatry Research: Neuroimaging, vol. 214, no. 1, pp. 16-23. https://doi.org/10.1016/j.pscychresns.2013.05.010

@article{ffd2df114066460a9943bb2b1a28df46,

title = "Executive dysfunction correlates with caudate nucleus atrophy in patients with white matter changes on MRI: A subset of LADIS",

abstract = "White matter changes (WMC) are common magnetic resonance imaging (MRI) findings, particularly in the elderly. Recent studies such as the Leukoaraiosis and Disability Study (LADIS) have found that WMC relate to adverse outcomes including cognitive impairment, depression, disability, unsteadiness and falls in cross-sectional and follow-up studies. Frontostriatal (or frontosubcortical) brain circuits may serve many of these functions, with the caudate nuclei playing a role in convergence of cognitive functions. This study aimed to determine whether reduced caudate volume relates to cognitive functions (executive functions, memory functions and speed of processing) and WMC. We determined caudate nuclei volumes, through manual tracing, on a subgroup of the LADIS study ( n=66) from four centres with baseline and 3-year follow-up MRI scans. Regression analysis was used to assess relationships between caudate volume, cognitive function and WMC. Severity of WMC did not relate to caudate volume. Smaller caudate volumes were significantly associated with poorer executive functioning at baseline and at 3 years, but were not associated with scores of memory or speed of processing. Thus, in patients with WMC, a surrogate of small vessel disease, caudate atrophy relates to the dysexecutive syndrome, supporting the role of caudate as an important part of the frontostriatal circuit.",

author = "Macfarlane, {Matthew Duncan} and Looi, {Jeffrey Chee Leong} and Mark Walterfang and Gabriela Spulber and Dennis Velakoulis and Milita Crisby and Eva Orndahl and Timo Erkinjuntti and Ellen Garde and Gunhild Waldemar and Anders Wallin and Lars-Olof Wahlund and Group, {LADIS Study}",

year = "2013",

month = oct,

day = "30",

doi = "10.1016/j.pscychresns.2013.05.010",

language = "English",

volume = "214",

pages = "16--23",

journal = "Psychiatry Research: Neuroimaging",

issn = "0925-4927",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Executive dysfunction correlates with caudate nucleus atrophy in patients with white matter changes on MRI: A subset of LADIS

AU - Macfarlane, Matthew Duncan

AU - Looi, Jeffrey Chee Leong

AU - Walterfang, Mark

AU - Spulber, Gabriela

AU - Velakoulis, Dennis

AU - Crisby, Milita

AU - Orndahl, Eva

AU - Erkinjuntti, Timo

AU - Garde, Ellen

AU - Waldemar, Gunhild

AU - Wallin, Anders

AU - Wahlund, Lars-Olof

AU - Group, LADIS Study

PY - 2013/10/30

Y1 - 2013/10/30

N2 - White matter changes (WMC) are common magnetic resonance imaging (MRI) findings, particularly in the elderly. Recent studies such as the Leukoaraiosis and Disability Study (LADIS) have found that WMC relate to adverse outcomes including cognitive impairment, depression, disability, unsteadiness and falls in cross-sectional and follow-up studies. Frontostriatal (or frontosubcortical) brain circuits may serve many of these functions, with the caudate nuclei playing a role in convergence of cognitive functions. This study aimed to determine whether reduced caudate volume relates to cognitive functions (executive functions, memory functions and speed of processing) and WMC. We determined caudate nuclei volumes, through manual tracing, on a subgroup of the LADIS study ( n=66) from four centres with baseline and 3-year follow-up MRI scans. Regression analysis was used to assess relationships between caudate volume, cognitive function and WMC. Severity of WMC did not relate to caudate volume. Smaller caudate volumes were significantly associated with poorer executive functioning at baseline and at 3 years, but were not associated with scores of memory or speed of processing. Thus, in patients with WMC, a surrogate of small vessel disease, caudate atrophy relates to the dysexecutive syndrome, supporting the role of caudate as an important part of the frontostriatal circuit.

AB - White matter changes (WMC) are common magnetic resonance imaging (MRI) findings, particularly in the elderly. Recent studies such as the Leukoaraiosis and Disability Study (LADIS) have found that WMC relate to adverse outcomes including cognitive impairment, depression, disability, unsteadiness and falls in cross-sectional and follow-up studies. Frontostriatal (or frontosubcortical) brain circuits may serve many of these functions, with the caudate nuclei playing a role in convergence of cognitive functions. This study aimed to determine whether reduced caudate volume relates to cognitive functions (executive functions, memory functions and speed of processing) and WMC. We determined caudate nuclei volumes, through manual tracing, on a subgroup of the LADIS study ( n=66) from four centres with baseline and 3-year follow-up MRI scans. Regression analysis was used to assess relationships between caudate volume, cognitive function and WMC. Severity of WMC did not relate to caudate volume. Smaller caudate volumes were significantly associated with poorer executive functioning at baseline and at 3 years, but were not associated with scores of memory or speed of processing. Thus, in patients with WMC, a surrogate of small vessel disease, caudate atrophy relates to the dysexecutive syndrome, supporting the role of caudate as an important part of the frontostriatal circuit.

U2 - 10.1016/j.pscychresns.2013.05.010

DO - 10.1016/j.pscychresns.2013.05.010

M3 - Journal article

C2 - 23916538

SN - 0925-4927

VL - 214

SP - 16

EP - 23

JO - Psychiatry Research: Neuroimaging

JF - Psychiatry Research: Neuroimaging

IS - 1

ER -

Executive dysfunction correlates with caudate nucleus atrophy in patients with white matter changes on MRI: A subset of LADIS

Abstract

Access to Document

Fingerprint

Cite this