Evidence of Bordetella pertussis infection in vaccinated 1-year-old Danish children

Marie-Louise von Linstow; Peter Lotko Pontoppidan; Carl-Heinz Wirsing von König; James D Cherry; Birthe Høgh

doi:10.1007/s00431-010-1192-9

Evidence of Bordetella pertussis infection in vaccinated 1-year-old Danish children

Marie-Louise von Linstow, Peter Lotko Pontoppidan, Carl-Heinz Wirsing von König, James D Cherry, Birthe Høgh

5 Citations (Scopus)

Abstract

We measured IgA and IgG antibodies to pertussis toxin (PT) and filamentous hemagglutinin (FHA) in sera from 203 1-year-old children who had received one to three doses of a monocomponent PT toxoid vaccine. Ten children (5%) had IgA antibody to PT indicating recent infection; seven of these children had received three doses of vaccine. PT IgA responders did not have significantly longer coughing episodes than PT IgA non-responders. Since an IgA antibody response occurs in only ̃50% of infected children, the actual infection rate in our cohort is estimated to ̃10%. The apparent high Bordetella pertussis infection rate in Danish infants suggests that the monocomponent PT toxoid vaccine used in Denmark has limited efficacy against B. pertussis infection. A prospective immunization study comparing a multi-component vaccine with the present monocomponent PT toxoid vaccine should be undertaken.

Original language	English
Journal	European Journal of Pediatrics
Volume	169
Issue number	9
Pages (from-to)	1119-22
ISSN	0340-6199
DOIs	https://doi.org/10.1007/s00431-010-1192-9
Publication status	Published - Sept 2010

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title = "Evidence of Bordetella pertussis infection in vaccinated 1-year-old Danish children",

abstract = "We measured IgA and IgG antibodies to pertussis toxin (PT) and filamentous hemagglutinin (FHA) in sera from 203 1-year-old children who had received one to three doses of a monocomponent PT toxoid vaccine. Ten children (5%) had IgA antibody to PT indicating recent infection; seven of these children had received three doses of vaccine. PT IgA responders did not have significantly longer coughing episodes than PT IgA non-responders. Since an IgA antibody response occurs in only{\~ }50% of infected children, the actual infection rate in our cohort is estimated to{\~ }10%. The apparent high Bordetella pertussis infection rate in Danish infants suggests that the monocomponent PT toxoid vaccine used in Denmark has limited efficacy against B. pertussis infection. A prospective immunization study comparing a multi-component vaccine with the present monocomponent PT toxoid vaccine should be undertaken.",

author = "{von Linstow}, Marie-Louise and Pontoppidan, {Peter Lotko} and {von K{\"o}nig}, {Carl-Heinz Wirsing} and Cherry, {James D} and Birthe H{\o}gh",

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doi = "10.1007/s00431-010-1192-9",

language = "English",

volume = "169",

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journal = "European Journal of Pediatrics",

issn = "0340-6199",

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TY - JOUR

T1 - Evidence of Bordetella pertussis infection in vaccinated 1-year-old Danish children

AU - von Linstow, Marie-Louise

AU - Pontoppidan, Peter Lotko

AU - von König, Carl-Heinz Wirsing

AU - Cherry, James D

AU - Høgh, Birthe

PY - 2010/9

Y1 - 2010/9

N2 - We measured IgA and IgG antibodies to pertussis toxin (PT) and filamentous hemagglutinin (FHA) in sera from 203 1-year-old children who had received one to three doses of a monocomponent PT toxoid vaccine. Ten children (5%) had IgA antibody to PT indicating recent infection; seven of these children had received three doses of vaccine. PT IgA responders did not have significantly longer coughing episodes than PT IgA non-responders. Since an IgA antibody response occurs in only ̃50% of infected children, the actual infection rate in our cohort is estimated to ̃10%. The apparent high Bordetella pertussis infection rate in Danish infants suggests that the monocomponent PT toxoid vaccine used in Denmark has limited efficacy against B. pertussis infection. A prospective immunization study comparing a multi-component vaccine with the present monocomponent PT toxoid vaccine should be undertaken.

AB - We measured IgA and IgG antibodies to pertussis toxin (PT) and filamentous hemagglutinin (FHA) in sera from 203 1-year-old children who had received one to three doses of a monocomponent PT toxoid vaccine. Ten children (5%) had IgA antibody to PT indicating recent infection; seven of these children had received three doses of vaccine. PT IgA responders did not have significantly longer coughing episodes than PT IgA non-responders. Since an IgA antibody response occurs in only ̃50% of infected children, the actual infection rate in our cohort is estimated to ̃10%. The apparent high Bordetella pertussis infection rate in Danish infants suggests that the monocomponent PT toxoid vaccine used in Denmark has limited efficacy against B. pertussis infection. A prospective immunization study comparing a multi-component vaccine with the present monocomponent PT toxoid vaccine should be undertaken.

U2 - 10.1007/s00431-010-1192-9

DO - 10.1007/s00431-010-1192-9

M3 - Journal article

SN - 0340-6199

VL - 169

SP - 1119

EP - 1122

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

IS - 9

ER -

Evidence of Bordetella pertussis infection in vaccinated 1-year-old Danish children

Abstract

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