Evidence for archaic adaptive introgression in humans

Fernando Racimo; Sriram Sankararaman; Rasmus Nielsen; Emilia Huerta-Sánchez

doi:10.1038/nrg3936

Evidence for archaic adaptive introgression in humans

Fernando Racimo, Sriram Sankararaman, Rasmus Nielsen, Emilia Huerta-Sánchez^*

^*Corresponding author for this work

232 Citations (Scopus)

Abstract

As modern and ancient DNA sequence data from diverse human populations accumulate, evidence is increasing in support of the existence of beneficial variants acquired from archaic humans that may have accelerated adaptation and improved survival in new environments-a process known as adaptive introgression. Within the past few years, a series of studies have identified genomic regions that show strong evidence for archaic adaptive introgression. Here, we provide an overview of the statistical methods developed to identify archaic introgressed fragments in the genome sequences of modern humans and to determine whether positive selection has acted on these fragments. We review recently reported examples of adaptive introgression, grouped by selection pressure, and consider the level of supporting evidence for each. Finally, we discuss challenges and recommendations for inferring selection on introgressed regions.

Original language	English
Journal	Nature Reviews Genetics
Volume	16
Issue number	6
Pages (from-to)	359-371
Number of pages	13
ISSN	1471-0056
DOIs	https://doi.org/10.1038/nrg3936
Publication status	Published - 18 May 2015

Access to Document

10.1038/nrg3936

Cite this

@article{cf28dff0a36049b786fe438494ed1acd,

title = "Evidence for archaic adaptive introgression in humans",

abstract = "As modern and ancient DNA sequence data from diverse human populations accumulate, evidence is increasing in support of the existence of beneficial variants acquired from archaic humans that may have accelerated adaptation and improved survival in new environments-a process known as adaptive introgression. Within the past few years, a series of studies have identified genomic regions that show strong evidence for archaic adaptive introgression. Here, we provide an overview of the statistical methods developed to identify archaic introgressed fragments in the genome sequences of modern humans and to determine whether positive selection has acted on these fragments. We review recently reported examples of adaptive introgression, grouped by selection pressure, and consider the level of supporting evidence for each. Finally, we discuss challenges and recommendations for inferring selection on introgressed regions.",

author = "Fernando Racimo and Sriram Sankararaman and Rasmus Nielsen and Emilia Huerta-S{\'a}nchez",

year = "2015",

month = may,

day = "18",

doi = "10.1038/nrg3936",

language = "English",

volume = "16",

pages = "359--371",

journal = "Nature Reviews Genetics",

issn = "1471-0056",

publisher = "nature publishing group",

number = "6",

}

TY - JOUR

T1 - Evidence for archaic adaptive introgression in humans

AU - Racimo, Fernando

AU - Sankararaman, Sriram

AU - Nielsen, Rasmus

AU - Huerta-Sánchez, Emilia

PY - 2015/5/18

Y1 - 2015/5/18

N2 - As modern and ancient DNA sequence data from diverse human populations accumulate, evidence is increasing in support of the existence of beneficial variants acquired from archaic humans that may have accelerated adaptation and improved survival in new environments-a process known as adaptive introgression. Within the past few years, a series of studies have identified genomic regions that show strong evidence for archaic adaptive introgression. Here, we provide an overview of the statistical methods developed to identify archaic introgressed fragments in the genome sequences of modern humans and to determine whether positive selection has acted on these fragments. We review recently reported examples of adaptive introgression, grouped by selection pressure, and consider the level of supporting evidence for each. Finally, we discuss challenges and recommendations for inferring selection on introgressed regions.

AB - As modern and ancient DNA sequence data from diverse human populations accumulate, evidence is increasing in support of the existence of beneficial variants acquired from archaic humans that may have accelerated adaptation and improved survival in new environments-a process known as adaptive introgression. Within the past few years, a series of studies have identified genomic regions that show strong evidence for archaic adaptive introgression. Here, we provide an overview of the statistical methods developed to identify archaic introgressed fragments in the genome sequences of modern humans and to determine whether positive selection has acted on these fragments. We review recently reported examples of adaptive introgression, grouped by selection pressure, and consider the level of supporting evidence for each. Finally, we discuss challenges and recommendations for inferring selection on introgressed regions.

UR - http://www.scopus.com/inward/record.url?scp=84929518810&partnerID=8YFLogxK

U2 - 10.1038/nrg3936

DO - 10.1038/nrg3936

M3 - Review

C2 - 25963373

AN - SCOPUS:84929518810

SN - 1471-0056

VL - 16

SP - 359

EP - 371

JO - Nature Reviews Genetics

JF - Nature Reviews Genetics

IS - 6

ER -

Evidence for archaic adaptive introgression in humans

Abstract

Access to Document

Other files and links

Fingerprint

Cite this